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Acute Eosinophilic Leukemia

MedGen UID:
44121
•Concept ID:
C0023439
•
Neoplastic Process
Synonyms: Acute Eosinophilic Leukemias; Eosinophilic Leukemia, Acute; Eosinophilic Leukemias, Acute; Leukemia, Acute Eosinophilic; Leukemia, Eosinophilic, Acute; Leukemias, Acute Eosinophilic
SNOMED CT: Acute eosinophilic leukemia (277604002); Acute eosinophilic leukemia (1162993004)

Definition

A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Eosinophilic Leukemia

Professional guidelines

PubMed

World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management.
Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management.
Gotlib J
Am J Hematol 2017 Nov;92(11):1243-1259. doi: 10.1002/ajh.24880. PMID: 29044676

Recent clinical studies

Etiology

Predicting severity and clinical course of acute rejection after liver transplantation using blood eosinophil count.
Rodríguez-Perálvarez M, Germani G, Tsochatzis E, Rolando N, Luong TV, Dhillon AP, Thorburn D, O'Beirne J, Patch D, Burroughs AK
Transpl Int 2012 May;25(5):555-63. Epub 2012 Mar 15 doi: 10.1111/j.1432-2277.2012.01457.x. PMID: 22420754
Eosinophilic folliculitis following allogeneic peripheral blood stem cell transplantation: case report and review.
Goiriz R, Guhl-Millán G, Peñas PF, Fernández-Herrera J, Daudén E, Fraga J, García-Diez A
J Cutan Pathol 2007 Dec;34 Suppl 1:33-6. doi: 10.1111/j.1600-0560.2006.00725.x. PMID: 17997736
A case of monosomy-7 eosinophilic leukemia and neurofibromatosis, terminated with disseminated cryptococcosis.
Song HS, Park SK
Korean J Intern Med 1987 Jan;2(1):131-4. doi: 10.3904/kjim.1987.2.1.131. PMID: 3155322Free PMC Article

Diagnosis

Acute eosinophilic leukemia in a patient with preexistent myelodysplastic syndrome.
Murakawa M, Shibuya T, Taniguchi S, Nakashima K, Okamura T, Harada M, Niho Y
Acta Haematol 1991;86(1):42-5. doi: 10.1159/000204798. PMID: 1950362
Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1.
Harrington DS, Peterson C, Ness M, Sanger W, Smith DM, Vaughan W
Am J Clin Pathol 1988 Oct;90(4):464-9. doi: 10.1093/ajcp/90.4.464. PMID: 3052018
Acute eosinophilic leukemia with a translocation (10p+;11q-).
Broustet A, Bernard P, Dachary D, David B, Marit G, Lacombe F, Issanchou AM, Reiffers J
Cancer Genet Cytogenet 1986 Apr 15;21(4):327-33. doi: 10.1016/0165-4608(86)90213-x. PMID: 3955530
Acute nonlymphocytic leukemia with eosinophilic differentiation.
Gabbas AG, Li CY
Am J Hematol 1986 Jan;21(1):29-38. doi: 10.1002/ajh.2830210105. PMID: 3706287
Acute eosinophilic leukemia: characterization by cytochemistry, chromosomal analysis, and in vitro colony formation.
Schmitz N, Maubach PA, Gödde-Salz E, Gassmann W, Löffler H
Klin Wochenschr 1985 Feb 4;63(3):133-7. doi: 10.1007/BF01734251. PMID: 3974175

Therapy

Complete and long-lasting cytologic and molecular remission of FIP1L1-PDGFRA-positive acute eosinophil myeloid leukaemia, treated with low-dose imatinib monotherapy.
Barraco D, Carobolante F, Candoni A, Simeone E, Piccaluga P, Tabanelli V, Fanin R
Eur J Haematol 2014 Jun;92(6):541-5. Epub 2014 Feb 19 doi: 10.1111/ejh.12272. PMID: 24460680
Predicting severity and clinical course of acute rejection after liver transplantation using blood eosinophil count.
Rodríguez-Perálvarez M, Germani G, Tsochatzis E, Rolando N, Luong TV, Dhillon AP, Thorburn D, O'Beirne J, Patch D, Burroughs AK
Transpl Int 2012 May;25(5):555-63. Epub 2012 Mar 15 doi: 10.1111/j.1432-2277.2012.01457.x. PMID: 22420754
A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid.
Yu RQ, Huang W, Chen SJ, Jiang SD, Chen Z
Leukemia 1997 Apr;11(4):609-11. doi: 10.1038/sj.leu.2400600. PMID: 9096703
Shift in phenotype of acute T-lymphocytic leukemia to eosinophilic leukemia: a case report.
Preis PP, Zielinski CC, Linkesch W, Bettelheim P, Radaskiewicz T, Pavelka M, Haas O, Aiginger P
Wien Klin Wochenschr 1988 May 13;100(10):331-6. PMID: 3261061
Acute eosinophilic leukemia. An ultrastructural study.
Anteunis A, Audebert AA, Krulik M, Debray J, Robineaux R
Virchows Arch B Cell Pathol 1978 May 19;27(3):237-48. doi: 10.1007/BF02888998. PMID: 96582

Prognosis

Predicting severity and clinical course of acute rejection after liver transplantation using blood eosinophil count.
Rodríguez-Perálvarez M, Germani G, Tsochatzis E, Rolando N, Luong TV, Dhillon AP, Thorburn D, O'Beirne J, Patch D, Burroughs AK
Transpl Int 2012 May;25(5):555-63. Epub 2012 Mar 15 doi: 10.1111/j.1432-2277.2012.01457.x. PMID: 22420754
Acute eosinophilic leukemia with a (10;11) chromosomal translocation.
Fischkoff SA, Testa JR, Schiffer CA
Leukemia 1988 Jun;2(6):394-7. PMID: 3374171
Acute nonlymphocytic leukemia with eosinophilic differentiation.
Gabbas AG, Li CY
Am J Hematol 1986 Jan;21(1):29-38. doi: 10.1002/ajh.2830210105. PMID: 3706287
CSF cytology of a patient with conversion of an acute lymphatic leukemia to an acute eosinophilic leukemia.
Kollegger H, Preis P, Maida E, Zielinski CC, Linkesch W, Bettelheim P, Aiginger P
Eur Neurol 1986;25(5):320-6. doi: 10.1159/000116029. PMID: 3465536
Acute eosinophilic leukemia: characterization by cytochemistry, chromosomal analysis, and in vitro colony formation.
Schmitz N, Maubach PA, Gödde-Salz E, Gassmann W, Löffler H
Klin Wochenschr 1985 Feb 4;63(3):133-7. doi: 10.1007/BF01734251. PMID: 3974175

Clinical prediction guides

Predicting severity and clinical course of acute rejection after liver transplantation using blood eosinophil count.
Rodríguez-Perálvarez M, Germani G, Tsochatzis E, Rolando N, Luong TV, Dhillon AP, Thorburn D, O'Beirne J, Patch D, Burroughs AK
Transpl Int 2012 May;25(5):555-63. Epub 2012 Mar 15 doi: 10.1111/j.1432-2277.2012.01457.x. PMID: 22420754
CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11).
Salmon-Nguyen F, Busson M, Daniel M, Leblanc T, Bernard OA, Berger R
Cancer Genet Cytogenet 2000 Oct 15;122(2):137-40. doi: 10.1016/s0165-4608(00)00277-6. PMID: 11106826
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K
Genes Chromosomes Cancer 1999 Nov;26(3):192-202. doi: 10.1002/(sici)1098-2264(199911)26:3<192::aid-gcc2>3.0.co;2-e. PMID: 10502316
Multiple myeloma terminating in acute eosinophilic leukemia.
Maeda K, VanSlyck EJ, VanDyke DL
Cancer Genet Cytogenet 1985 Mar 1;16(1):81-9. doi: 10.1016/0165-4608(85)90080-9. PMID: 3971334
Acute eosinophilic leukemia. An ultrastructural study.
Anteunis A, Audebert AA, Krulik M, Debray J, Robineaux R
Virchows Arch B Cell Pathol 1978 May 19;27(3):237-48. doi: 10.1007/BF02888998. PMID: 96582

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