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Liver Neoplasms, Experimental

MedGen UID:
44184
•Concept ID:
C0023904
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Liver Neoplasm; Experimental Liver Neoplasms; Liver Neoplasm, Experimental; Neoplasms, Experimental Liver

Definition

Experimentally induced tumors of the LIVER. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Neoplasms, Experimental

Professional guidelines

PubMed

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Rizvi S, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article

Recent clinical studies

Etiology

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W
Nat Med 2021 Jan;27(1):152-164. Epub 2021 Jan 4 doi: 10.1038/s41591-020-1131-x. PMID: 33398162Free PMC Article
Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide.
Pittala S, Krelin Y, Shoshan-Barmatz V
Neoplasia 2018 Jun;20(6):594-609. Epub 2018 May 7 doi: 10.1016/j.neo.2018.02.012. PMID: 29747160Free PMC Article
Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15.
Zhou M, Luo J, Chen M, Yang H, Learned RM, DePaoli AM, Tian H, Ling L
J Hepatol 2017 Jun;66(6):1182-1192. Epub 2017 Feb 9 doi: 10.1016/j.jhep.2017.01.027. PMID: 28189755
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
Proteoglycans in liver cancer.
Baghy K, Tátrai P, Regős E, Kovalszky I
World J Gastroenterol 2016 Jan 7;22(1):379-93. doi: 10.3748/wjg.v22.i1.379. PMID: 26755884Free PMC Article

Diagnosis

Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Li W, Xiao J, Zhou X, Xu M, Hu C, Xu X, Lu Y, Liu C, Xue S, Nie L, Zhang H, Li Z, Zhang Y, Ji F, Hui L, Tao W, Wei B, Wang H
J Clin Invest 2015 Nov 2;125(11):4239-54. Epub 2015 Oct 12 doi: 10.1172/JCI81203. PMID: 26457732Free PMC Article
Stem cell origins and animal models of hepatocellular carcinoma.
Aravalli RN, Steer CJ, Sahin MB, Cressman EN
Dig Dis Sci 2010 May;55(5):1241-50. Epub 2009 Jun 10 doi: 10.1007/s10620-009-0861-x. PMID: 19513833
Rodent carcinogenicity of peroxisome proliferators and issues on human relevance.
Lai DY
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2004 May;22(1):37-55. doi: 10.1081/GNC-120038005. PMID: 15845221
Impacts of chemicals on liver cancer risk.
Wogan GN
Semin Cancer Biol 2000 Jun;10(3):201-10. doi: 10.1006/scbi.2000.0320. PMID: 10936069

Therapy

Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.
Liu C, Yang Y, Chen C, Li L, Li J, Wang X, Chu Q, Qiu L, Ba Q, Li X, Wang H
Nat Commun 2021 Sep 30;12(1):5725. doi: 10.1038/s41467-021-25967-9. PMID: 34593796Free PMC Article
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W
Cell Mol Gastroenterol Hepatol 2021;11(2):407-431. Epub 2020 Sep 12 doi: 10.1016/j.jcmgh.2020.09.003. PMID: 32932015Free PMC Article
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Wai Ho TS, Chow P, Toh HC, Reversade B, Gruenewald S, Han W
J Hepatol 2020 Apr;72(4):725-735. Epub 2019 Nov 11 doi: 10.1016/j.jhep.2019.10.026. PMID: 31726117
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.
Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS
Gut 2020 Feb;69(2):365-379. Epub 2019 May 10 doi: 10.1136/gutjnl-2018-317257. PMID: 31076403
Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models.
Lu Z, Zuo B, Jing R, Gao X, Rao Q, Liu Z, Qi H, Guo H, Yin H
J Hepatol 2017 Oct;67(4):739-748. Epub 2017 May 24 doi: 10.1016/j.jhep.2017.05.019. PMID: 28549917

Prognosis

Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways.
Yassin NYS, AbouZid SF, El-Kalaawy AM, Ali TM, Almehmadi MM, Ahmed OM
Biomed Pharmacother 2022 Jan;145:112409. Epub 2021 Nov 12 doi: 10.1016/j.biopha.2021.112409. PMID: 34781148
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Wai Ho TS, Chow P, Toh HC, Reversade B, Gruenewald S, Han W
J Hepatol 2020 Apr;72(4):725-735. Epub 2019 Nov 11 doi: 10.1016/j.jhep.2019.10.026. PMID: 31726117
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
Hepatocarcinogenesis.
Lau JY, Lai CL
Trop Gastroenterol 1990 Jan-Mar;11(1):9-24. PMID: 2162576

Clinical prediction guides

Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Wai Ho TS, Chow P, Toh HC, Reversade B, Gruenewald S, Han W
J Hepatol 2020 Apr;72(4):725-735. Epub 2019 Nov 11 doi: 10.1016/j.jhep.2019.10.026. PMID: 31726117
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC
Gastroenterology 2018 Aug;155(2):557-571.e14. Epub 2018 May 5 doi: 10.1053/j.gastro.2018.04.032. PMID: 29733835Free PMC Article
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Li W, Xiao J, Zhou X, Xu M, Hu C, Xu X, Lu Y, Liu C, Xue S, Nie L, Zhang H, Li Z, Zhang Y, Ji F, Hui L, Tao W, Wei B, Wang H
J Clin Invest 2015 Nov 2;125(11):4239-54. Epub 2015 Oct 12 doi: 10.1172/JCI81203. PMID: 26457732Free PMC Article
Promotion of hepatocarcinogenesis in humans and animal models.
Köhle C, Schwarz M, Bock KW
Arch Toxicol 2008 Sep;82(9):623-31. Epub 2008 Jan 16 doi: 10.1007/s00204-007-0273-7. PMID: 18204979
Human and experimental hepatocarcinogenesis.
Schaff Z, Kovalszky I, Nagy P, Zalatnai A, Jeney A, Lapis K
Scand J Gastroenterol Suppl 1998;228:90-7. doi: 10.1080/003655298750026615. PMID: 9867118

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