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Dysmenorrhea

MedGen UID:
4429
•Concept ID:
C0013390
•
Disease or Syndrome
Synonyms: Dysmenorrheas; Menstrual Pain; Menstrual Pains; Menstruation, Painful; Menstruations, Painful; Pain, Menstrual; Painful Menstruation; Painful Menstruations; Pains, Menstrual
SNOMED CT: Menorrhalgia (266599000); Menstrual cramp (431416001); Period pain (266599000); Menstrual cramps (266599000); Dysmenorrhea (266599000); Period pain present (289900009); Painful menstruation (289900009)
 
HPO: HP:0100607

Definition

Pain during menstruation that interferes with daily activities. [from HPO]

Conditions with this feature

Endometriosis, susceptibility to, 1
MedGen UID:
338749
•Concept ID:
C1851649
•
Finding
See: Condition Record
Endometriosis, susceptibility to, 1

Professional guidelines

PubMed

Efficacy of Physiotherapy Treatment in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.
López-Liria R, Torres-Álamo L, Vega-Ramírez FA, García-Luengo AV, Aguilar-Parra JM, Trigueros-Ramos R, Rocamora-Pérez P
Int J Environ Res Public Health 2021 Jul 23;18(15) doi: 10.3390/ijerph18157832. PMID: 34360122Free PMC Article
Primary Dysmenorrhea: Assessment and Treatment.
Guimarães I, Póvoa AM
Rev Bras Ginecol Obstet 2020 Aug;42(8):501-507. Epub 2020 Jun 19 doi: 10.1055/s-0040-1712131. PMID: 32559803Free PMC Article
Diagnosis and treatment of müllerian malformations.
Passos IMPE, Britto RL
Taiwan J Obstet Gynecol 2020 Mar;59(2):183-188. doi: 10.1016/j.tjog.2020.01.003. PMID: 32127135

Recent clinical studies

Etiology

Efficacy of Physiotherapy Treatment in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.
López-Liria R, Torres-Álamo L, Vega-Ramírez FA, García-Luengo AV, Aguilar-Parra JM, Trigueros-Ramos R, Rocamora-Pérez P
Int J Environ Res Public Health 2021 Jul 23;18(15) doi: 10.3390/ijerph18157832. PMID: 34360122Free PMC Article
Primary Dysmenorrhea: Diagnosis and Therapy.
Ferries-Rowe E, Corey E, Archer JS
Obstet Gynecol 2020 Nov;136(5):1047-1058. doi: 10.1097/AOG.0000000000004096. PMID: 33030880
No. 345-Primary Dysmenorrhea Consensus Guideline.
Burnett M, Lemyre M
J Obstet Gynaecol Can 2017 Jul;39(7):585-595. doi: 10.1016/j.jogc.2016.12.023. PMID: 28625286
What we know about primary dysmenorrhea today: a critical review.
Iacovides S, Avidon I, Baker FC
Hum Reprod Update 2015 Nov-Dec;21(6):762-78. Epub 2015 Sep 7 doi: 10.1093/humupd/dmv039. PMID: 26346058
The prevalence and risk factors of dysmenorrhea.
Ju H, Jones M, Mishra G
Epidemiol Rev 2014;36:104-13. Epub 2013 Nov 26 doi: 10.1093/epirev/mxt009. PMID: 24284871

Diagnosis

Dysmenorrhea.
McKenna KA, Fogleman CD
Am Fam Physician 2021 Aug 1;104(2):164-170. PMID: 34383437
Primary Dysmenorrhea: Diagnosis and Therapy.
Ferries-Rowe E, Corey E, Archer JS
Obstet Gynecol 2020 Nov;136(5):1047-1058. doi: 10.1097/AOG.0000000000004096. PMID: 33030880
Primary Dysmenorrhea: Assessment and Treatment.
Guimarães I, Póvoa AM
Rev Bras Ginecol Obstet 2020 Aug;42(8):501-507. Epub 2020 Jun 19 doi: 10.1055/s-0040-1712131. PMID: 32559803Free PMC Article
Inflammatory Markers in Dysmenorrhea and Therapeutic Options.
Barcikowska Z, Rajkowska-Labon E, Grzybowska ME, Hansdorfer-Korzon R, Zorena K
Int J Environ Res Public Health 2020 Feb 13;17(4) doi: 10.3390/ijerph17041191. PMID: 32069859Free PMC Article
Adolescent Endometriosis: An Update.
Shim JY, Laufer MR
J Pediatr Adolesc Gynecol 2020 Apr;33(2):112-119. Epub 2019 Dec 5 doi: 10.1016/j.jpag.2019.11.011. PMID: 31812704

Therapy

Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized single-blind placebo-controlled trial.
Li PS, Peng XM, Niu XX, Xu L, Hung Yu Ng E, Wang CC, Dai JF, Lu J, Liang RN
Fertil Steril 2023 May;119(5):815-823. Epub 2023 Jan 27 doi: 10.1016/j.fertnstert.2023.01.034. PMID: 36716811
The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial.
Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T, Sahebkar A
Pain Res Manag 2021;2021:5529741. Epub 2021 May 26 doi: 10.1155/2021/5529741. PMID: 34122682Free PMC Article
Clinical trials on pain lowering effect of ginger: A narrative review.
Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, Riva A, Petrangolini G, Iannello G, Nichetti M, Infantino V, Perna S
Phytother Res 2020 Nov;34(11):2843-2856. Epub 2020 May 20 doi: 10.1002/ptr.6730. PMID: 32436242Free PMC Article
Medical treatment of endometriosis-related pain.
Vercellini P, Buggio L, Frattaruolo MP, Borghi A, Dridi D, Somigliana E
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:68-91. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.015. PMID: 29530425
Dietary supplements for dysmenorrhoea.
Pattanittum P, Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, Marjoribanks J
Cochrane Database Syst Rev 2016 Mar 22;3(3):CD002124. doi: 10.1002/14651858.CD002124.pub2. PMID: 27000311Free PMC Article

Prognosis

Placebo response of sham acupuncture in patients with primary dysmenorrhea: A meta-analysis.
Sun CY, Xiong ZY, Sun CY, Ma PH, Liu XY, Sun CY, Xin ZY, Liu BY, Liu CZ, Yan SY
J Integr Med 2023 Sep;21(5):455-463. Epub 2023 Aug 11 doi: 10.1016/j.joim.2023.08.005. PMID: 37620224
Electroacupuncture treatment of primary dysmenorrhea: A randomized, participant-blinded, sham-controlled clinical trial protocol.
Xue X, Liu X, Pan S, Li J, Wang S, Yuan H, Liu Y, Yue Z
PLoS One 2023;18(5):e0282541. Epub 2023 May 26 doi: 10.1371/journal.pone.0282541. PMID: 37235569Free PMC Article
Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52-mg levonorgestrel-releasing intrauterine system: randomized clinical trial.
Carvalho N, Margatho D, Cursino K, Benetti-Pinto CL, Bahamondes L
Fertil Steril 2018 Nov;110(6):1129-1136. doi: 10.1016/j.fertnstert.2018.07.003. PMID: 30396557
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505
The prevalence and risk factors of dysmenorrhea.
Ju H, Jones M, Mishra G
Epidemiol Rev 2014;36:104-13. Epub 2013 Nov 26 doi: 10.1093/epirev/mxt009. PMID: 24284871

Clinical prediction guides

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial.
Amzajerdi A, Keshavarz M, Ghorbali E, Pezaro S, Sarvi F
BMC Womens Health 2023 Mar 27;23(1):138. doi: 10.1186/s12905-023-02284-5. PMID: 36973702Free PMC Article
Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized single-blind placebo-controlled trial.
Li PS, Peng XM, Niu XX, Xu L, Hung Yu Ng E, Wang CC, Dai JF, Lu J, Liang RN
Fertil Steril 2023 May;119(5):815-823. Epub 2023 Jan 27 doi: 10.1016/j.fertnstert.2023.01.034. PMID: 36716811
Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple-blind, placebo-controlled clinical trial.
Bahrami A, Zarban A, Rezapour H, Agha Amini Fashami A, Ferns GA
Phytother Res 2021 Dec;35(12):6954-6962. Epub 2021 Oct 28 doi: 10.1002/ptr.7314. PMID: 34708460
Efficacy of Acupuncture in the Management of Primary Dysmenorrhea: A Randomized Controlled Trial.
Shetty GB, Shetty B, Mooventhan A
J Acupunct Meridian Stud 2018 Aug;11(4):153-158. Epub 2018 Apr 12 doi: 10.1016/j.jams.2018.04.001. PMID: 29654840
Biomarkers in endometriosis: challenges and opportunities.
Ahn SH, Singh V, Tayade C
Fertil Steril 2017 Mar;107(3):523-532. Epub 2017 Feb 8 doi: 10.1016/j.fertnstert.2017.01.009. PMID: 28189296

Recent systematic reviews

Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.
Zheng SH, Chen XX, Chen Y, Wu ZC, Chen XQ, Li XL
Reprod Biol Endocrinol 2023 Aug 29;21(1):79. doi: 10.1186/s12958-023-01126-1. PMID: 37644533Free PMC Article
Factors Associated with the Prevalence and Severity of Menstrual-Related Symptoms: A Systematic Review and Meta-Analysis.
Mitsuhashi R, Sawai A, Kiyohara K, Shiraki H, Nakata Y
Int J Environ Res Public Health 2022 Dec 29;20(1) doi: 10.3390/ijerph20010569. PMID: 36612891Free PMC Article
Effects of vitamin D supplementation in endometriosis: a systematic review.
Kalaitzopoulos DR, Samartzis N, Daniilidis A, Leeners B, Makieva S, Nirgianakis K, Dedes I, Metzler JM, Imesch P, Lempesis IG
Reprod Biol Endocrinol 2022 Dec 28;20(1):176. doi: 10.1186/s12958-022-01051-9. PMID: 36578019Free PMC Article
Efficacy of Physiotherapy Treatment in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.
López-Liria R, Torres-Álamo L, Vega-Ramírez FA, García-Luengo AV, Aguilar-Parra JM, Trigueros-Ramos R, Rocamora-Pérez P
Int J Environ Res Public Health 2021 Jul 23;18(15) doi: 10.3390/ijerph18157832. PMID: 34360122Free PMC Article
An update and systematic review on the treatment of primary dysmenorrhea.
Sharghi M, Mansurkhani SM, Larky DA, Kooti W, Niksefat M, Firoozbakht M, Behzadifar M, Azami M, Servatyari K, Jouybari L
JBRA Assist Reprod 2019 Jan 31;23(1):51-57. doi: 10.5935/1518-0557.20180083. PMID: 30521155Free PMC Article

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