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Acute Myeloid Leukemia with Gene Mutations

MedGen UID:
443160
Concept ID:
C2826176
Neoplastic Process
Synonym: AML with Gene Mutations

Definition

A term referring to acute myeloid leukemias associated with gene mutations most often of the FLT3, NPM1, and CEBPA genes. These leukemias may have normal karyotypes or additional chromosomal aberrations. [from NCI]

Recent clinical studies

Etiology

Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article
Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, Bloomfield CD, Estey E, Burnett A, Cornelissen JJ, Scheinberg DA, Bouscary D, Linch DC
Nat Rev Dis Primers 2016 Mar 10;2:16010. doi: 10.1038/nrdp.2016.10. PMID: 27159408

Diagnosis

Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Swaminathan M, Bourgeois W, Armstrong SA, Wang ES
Cancer J 2022 Jan-Feb 01;28(1):62-66. doi: 10.1097/PPO.0000000000000571. PMID: 35072375
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Therapy

Daver N, Venugopal S, Ravandi F
Blood Cancer J 2021 May 27;11(5):104. doi: 10.1038/s41408-021-00495-3. PMID: 34045454Free PMC Article
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article
Kiyoi H, Kawashima N, Ishikawa Y
Cancer Sci 2020 Feb;111(2):312-322. Epub 2019 Dec 30 doi: 10.1111/cas.14274. PMID: 31821677Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Prognosis

Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Kishtagari A, Levine RL, Viny AD
Curr Opin Hematol 2020 Mar;27(2):49-57. doi: 10.1097/MOH.0000000000000567. PMID: 31972687
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Clinical prediction guides

George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Recent systematic reviews

Oh S, Kim E
Clin Exp Med 2023 Oct;23(6):2705-2714. Epub 2023 Mar 25 doi: 10.1007/s10238-023-01041-0. PMID: 36964818
Sutandyo N, Mulyasari R, Kosasih A, Rinaldi I, Louisa M, Kevinsyah AP, Winston K
Asian Pac J Cancer Prev 2022 Apr 1;23(4):1107-1116. doi: 10.31557/APJCP.2022.23.4.1107. PMID: 35485665Free PMC Article
Solana-Altabella A, Ballesta-López O, Megías-Vericat JE, Martínez-Cuadrón D, Montesinos P
Expert Opin Emerg Drugs 2022 Mar;27(1):1-18. Epub 2022 Jan 25 doi: 10.1080/14728214.2021.2009800. PMID: 35076348
Zhou F, Chen B
Hematology 2018 Oct;23(9):608-612. Epub 2018 Jun 12 doi: 10.1080/10245332.2018.1482051. PMID: 29894279
Port M, Böttcher M, Thol F, Ganser A, Schlenk R, Wasem J, Neumann A, Pouryamout L
Ann Hematol 2014 Aug;93(8):1279-86. Epub 2014 May 7 doi: 10.1007/s00277-014-2072-6. PMID: 24801015

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