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Myocardial degeneration

MedGen UID:
44551
•Concept ID:
C0027046
•
Pathologic Function
Synonyms: Degeneration of heart; Mural degeneration of heart; Muscular degeneration of heart; Myocardial Degeneration
SNOMED CT: Myocardial degeneration (64077000); Muscular degeneration of heart (64077000); Mural degeneration of heart (64077000); Degeneration of heart (64077000)

Definition

Degeneration of myocardial tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial degeneration

Professional guidelines

PubMed

Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases.
Pucéat M
Curr Opin Pharmacol 2008 Apr;8(2):189-92. Epub 2008 Jan 28 doi: 10.1016/j.coph.2007.12.004. PMID: 18222729
Epicardial treatment of atrial fibrillation using cryoablation in an acute off-pump sheep model.
Doll N, Kornherr P, Aupperle H, Fabricius AM, Kiaii B, Ullmann C, Schneider K, Dhein S, Schoon HA, Rastan A, Walther T, Mohr FW
Thorac Cardiovasc Surg 2003 Oct;51(5):267-73. doi: 10.1055/s-2003-43086. PMID: 14571343

Recent clinical studies

Etiology

The Value of Myocardium and Kidney Histopathological and Immunohistochemical Findings in Accidental Hypothermia-Related Fatalities.
Hleșcu AA, Grigoraș A, Covatariu G, Moscalu M, Amalinei C
Medicina (Kaunas) 2022 Oct 23;58(11) doi: 10.3390/medicina58111507. PMID: 36363464Free PMC Article
Twenty-four-hour normothermic perfusion of isolated ex vivo hearts using plasma exchange.
Tchouta L, Drake D, Hoenerhoff M, Rojas-Pena A, Haft J, Owens G, Bartlett R; University of Michigan Department of Surgery Extracorporeal Life Support Laboratory
J Thorac Cardiovasc Surg 2022 Jul;164(1):128-138. Epub 2020 Dec 13 doi: 10.1016/j.jtcvs.2020.11.158. PMID: 33485659
Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells.
Cianflone E, Aquila I, Scalise M, Marotta P, Torella M, Nadal-Ginard B, Torella D
Cell Cycle 2018;17(8):927-946. Epub 2018 Jun 25 doi: 10.1080/15384101.2018.1464852. PMID: 29862928Free PMC Article
Pathogenesis of Arrhythmogenic Cardiomyopathy.
Asimaki A, Kleber AG, Saffitz JE
Can J Cardiol 2015 Nov;31(11):1313-24. Epub 2015 Apr 24 doi: 10.1016/j.cjca.2015.04.012. PMID: 26199027Free PMC Article
Calreticulin-STAT3 signaling pathway modulates mitochondrial function in a rat model of furazolidone-induced dilated cardiomyopathy.
Zhang M, Wei J, Shan H, Wang H, Zhu Y, Xue J, Lin L, Yan R
PLoS One 2013;8(6):e66779. Epub 2013 Jun 20 doi: 10.1371/journal.pone.0066779. PMID: 23818963Free PMC Article

Diagnosis

Comparative Structure of Male Mortality From Cardiac Causes in Five-Year Age Groups.
Drapkina OM, Samorodskaya IV
Kardiologiia 2023 Jan 31;63(1):21-28. doi: 10.18087/cardio.2023.1.n2076. PMID: 36749197
The Value of Myocardium and Kidney Histopathological and Immunohistochemical Findings in Accidental Hypothermia-Related Fatalities.
Hleșcu AA, Grigoraș A, Covatariu G, Moscalu M, Amalinei C
Medicina (Kaunas) 2022 Oct 23;58(11) doi: 10.3390/medicina58111507. PMID: 36363464Free PMC Article
Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity.
O'Brien PJ
Toxicology 2008 Mar 20;245(3):206-18. Epub 2007 Dec 17 doi: 10.1016/j.tox.2007.12.006. PMID: 18249481
Cardiac troponin I for accurate evaluation of cardiac status in myopathic patients.
Matsumura T, Saito T, Fujimura H, Shinno S
Brain Dev 2007 Sep;29(8):496-501. Epub 2007 Mar 21 doi: 10.1016/j.braindev.2007.01.009. PMID: 17376624
Ischemic and non-ischemic myocyte damage and antimyosin monoclonal imaging.
Nakata T, Shimamoto K
Jpn Circ J 1998 Feb;62(2):77-82. doi: 10.1253/jcj.62.77. PMID: 9559423

Therapy

Twenty-four-hour normothermic perfusion of isolated ex vivo hearts using plasma exchange.
Tchouta L, Drake D, Hoenerhoff M, Rojas-Pena A, Haft J, Owens G, Bartlett R; University of Michigan Department of Surgery Extracorporeal Life Support Laboratory
J Thorac Cardiovasc Surg 2022 Jul;164(1):128-138. Epub 2020 Dec 13 doi: 10.1016/j.jtcvs.2020.11.158. PMID: 33485659
Honokiol Protects against Anti-β1-Adrenergic Receptor Autoantibody-Induced Myocardial Dysfunction via Activation of Autophagy.
Wei XQ, Zhang HS, Wei GH, Zhang JG, Du YY, Tan HY, Yang J
Oxid Med Cell Longev 2018;2018:1640804. Epub 2018 Jul 18 doi: 10.1155/2018/1640804. PMID: 30116474Free PMC Article
Investigation of mechanism of drug-induced cardiac injury and torsades de pointes in cynomolgus monkeys.
Misner DL, Frantz C, Guo L, Gralinski MR, Senese PB, Ly J, Albassam M, Kolaja KL
Br J Pharmacol 2012 Apr;165(8):2771-86. doi: 10.1111/j.1476-5381.2011.01756.x. PMID: 22029876Free PMC Article
Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases.
Pucéat M
Curr Opin Pharmacol 2008 Apr;8(2):189-92. Epub 2008 Jan 28 doi: 10.1016/j.coph.2007.12.004. PMID: 18222729
Cardiac troponin I for accurate evaluation of cardiac status in myopathic patients.
Matsumura T, Saito T, Fujimura H, Shinno S
Brain Dev 2007 Sep;29(8):496-501. Epub 2007 Mar 21 doi: 10.1016/j.braindev.2007.01.009. PMID: 17376624

Prognosis

Gender Differences in Atrial Fibrosis and Cardiomyopathy Assessed by Left Atrial Low-Voltage Areas During Catheter Ablation of Atrial Fibrillation.
Masuda M, Matsuda Y, Uematsu H, Sugino A, Ooka H, Kudo S, Fujii S, Asai M, Iida O, Okamoto S, Ishihara T, Nanto K, Tsujimura T, Hata Y, Toyoshima T, Higashino N, Nakao S, Mano T
Am J Cardiol 2023 Sep 15;203:37-44. Epub 2023 Jul 21 doi: 10.1016/j.amjcard.2023.07.001. PMID: 37481810
Comparative Structure of Male Mortality From Cardiac Causes in Five-Year Age Groups.
Drapkina OM, Samorodskaya IV
Kardiologiia 2023 Jan 31;63(1):21-28. doi: 10.18087/cardio.2023.1.n2076. PMID: 36749197
Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines.
Misner DL, Kauss MA, Singh J, Uppal H, Bruening-Wright A, Liederer BM, Lin T, McCray B, La N, Nguyen T, Sampath D, Dragovich PS, O'Brien T, Zabka TS
Cardiovasc Toxicol 2017 Jul;17(3):307-318. doi: 10.1007/s12012-016-9387-6. PMID: 27783203
Investigation of mechanism of drug-induced cardiac injury and torsades de pointes in cynomolgus monkeys.
Misner DL, Frantz C, Guo L, Gralinski MR, Senese PB, Ly J, Albassam M, Kolaja KL
Br J Pharmacol 2012 Apr;165(8):2771-86. doi: 10.1111/j.1476-5381.2011.01756.x. PMID: 22029876Free PMC Article
Radiation-induced heart disease: review of experimental data on dose response and pathogenesis.
Schultz-Hector S
Int J Radiat Biol 1992 Feb;61(2):149-60. doi: 10.1080/09553009214550761. PMID: 1351901

Clinical prediction guides

The Value of Myocardium and Kidney Histopathological and Immunohistochemical Findings in Accidental Hypothermia-Related Fatalities.
Hleșcu AA, Grigoraș A, Covatariu G, Moscalu M, Amalinei C
Medicina (Kaunas) 2022 Oct 23;58(11) doi: 10.3390/medicina58111507. PMID: 36363464Free PMC Article
Calreticulin-STAT3 signaling pathway modulates mitochondrial function in a rat model of furazolidone-induced dilated cardiomyopathy.
Zhang M, Wei J, Shan H, Wang H, Zhu Y, Xue J, Lin L, Yan R
PLoS One 2013;8(6):e66779. Epub 2013 Jun 20 doi: 10.1371/journal.pone.0066779. PMID: 23818963Free PMC Article
Differences in myocardial sympathetic degeneration and the clinical features of the subtypes of Parkinson's disease.
Chung EJ, Kim EG, Kim MS, Bae SK, Seog DH, Oh SJ, Oh M, Kim SJ
J Clin Neurosci 2011 Jul;18(7):922-5. Epub 2011 May 12 doi: 10.1016/j.jocn.2010.12.024. PMID: 21570301
Cardiac troponin I for accurate evaluation of cardiac status in myopathic patients.
Matsumura T, Saito T, Fujimura H, Shinno S
Brain Dev 2007 Sep;29(8):496-501. Epub 2007 Mar 21 doi: 10.1016/j.braindev.2007.01.009. PMID: 17376624
Radiation-induced heart disease: review of experimental data on dose response and pathogenesis.
Schultz-Hector S
Int J Radiat Biol 1992 Feb;61(2):149-60. doi: 10.1080/09553009214550761. PMID: 1351901

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