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Splenic cyst

MedGen UID:
452367
Concept ID:
C0272407
Disease or Syndrome
Synonym: Cysts in spleen
SNOMED CT: Cyst of spleen (79040006); Splenic cyst (79040006); Spleen cyst (79040006)
 
HPO: HP:0030423

Definition

A closed sac located in the spleen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic cyst

Conditions with this feature

Hyperparathyroidism, transient neonatal
MedGen UID:
722059
Concept ID:
C1300287
Disease or Syndrome
Transient neonatal hyperparathyroidism is characterized by interference with placental maternal-fetal calcium transport, causing fetal calcium deficiency resulting in hyperparathyroidism and metabolic bone disease. Because 80% of calcium is transferred during the third trimester, abnormalities may not be detected on second-trimester ultrasounds. Affected infants present at birth with prenatal fractures, shortened ribs, and bowing of long bones, as well as respiratory and feeding difficulties. Postnatal recovery or improvement is observed once calcium is provided orally, with most patients showing complete resolution of skeletal abnormalities by 2 years of age (Suzuki et al., 2018).
Neonatal diabetes mellitus with congenital hypothyroidism
MedGen UID:
347541
Concept ID:
C1857775
Disease or Syndrome
Neonatal diabetes mellitus with congenital hypothyroidism (NDH) syndrome is characterized by intrauterine growth retardation and onset of nonimmune diabetes mellitus within the first few weeks of life. Other features include renal parenchymal disease, primarily renal cystic dysplasia, and hepatic disease, with hepatitis in some patients and hepatic fibrosis and cirrhosis in others. Facial dysmorphism, when present, consistently involves low-set ears, epicanthal folds, flat nasal bridge, long philtrum, and thin upper lip. Most patients exhibit developmental delay (Dimitri et al., 2015).
Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity
MedGen UID:
1841145
Concept ID:
C5830509
Disease or Syndrome
Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity (NEDIHSS) is an autosomal recessive disorder characterized by prenatal or neonatal onset of intracranial hemorrhage, usually with ventriculomegaly and calcifications, resulting in parenchymal brain damage. Some affected individuals have symptoms incompatible with life and die in utero. Those that survive show profound global developmental delay with almost no motor or cognitive skills, hypotonia, spasticity, and seizures. Other features may include facial dysmorphism, retinal vascular abnormalities, and poor overall growth. The pathogenesis of the disease likely results from dysfunction of vascular endothelial cells in the brain (Lecca et al., 2023).

Professional guidelines

PubMed

Yocum BP, Hwang M, Mesa H, Collins K
Int J Surg Pathol 2023 Aug;31(5):498-508. Epub 2022 Jul 11 doi: 10.1177/10668969221107080. PMID: 35818747
Giurazza F, Marra P, Mosconi C, Corvino F, Corvino A, Niola R
J Clin Ultrasound 2022 Nov;50(9):1360-1367. Epub 2022 Aug 30 doi: 10.1002/jcu.23298. PMID: 36053957
Lazow SP, Richman DM, Dionigi B, Staffa SJ, Benson CB, Buchmiller TL
Fetal Diagn Ther 2021;48(3):235-242. Epub 2021 Mar 17 doi: 10.1159/000512689. PMID: 33730724

Recent clinical studies

Etiology

Karaaslan B
Eur Rev Med Pharmacol Sci 2023 Sep;27(18):8550-8555. doi: 10.26355/eurrev_202309_33780. PMID: 37782171
DCunha AR, Rai E, Jacob TJK, Devasia AJ, Rebekah G
Pediatr Surg Int 2022 Oct;38(10):1405-1412. Epub 2022 Jul 29 doi: 10.1007/s00383-022-05182-3. PMID: 35906350
Lazow SP, Richman DM, Dionigi B, Staffa SJ, Benson CB, Buchmiller TL
Fetal Diagn Ther 2021;48(3):235-242. Epub 2021 Mar 17 doi: 10.1159/000512689. PMID: 33730724
López JJ, Lodwick DL, Cooper JN, Hogan M, King D, Minneci PC
J Surg Res 2017 Nov;219:1-4. Epub 2017 May 12 doi: 10.1016/j.jss.2017.05.029. PMID: 29078866
Akhan O, Dagoglu-Kartal MG, Ciftci T, Ozer C, Erbahceci A, Akinci D
Cardiovasc Intervent Radiol 2017 Sep;40(9):1421-1430. Epub 2017 May 1 doi: 10.1007/s00270-017-1650-0. PMID: 28462445

Diagnosis

Di Lena É, Safa N, Rahman S, Kaneva P, Feldman LS
Can J Surg 2023 Jul-Aug;66(4):E390-E395. Epub 2023 Jul 27 doi: 10.1503/cjs.010322. PMID: 37500107Free PMC Article
Yocum BP, Hwang M, Mesa H, Collins K
Int J Surg Pathol 2023 Aug;31(5):498-508. Epub 2022 Jul 11 doi: 10.1177/10668969221107080. PMID: 35818747
Lazow SP, Richman DM, Dionigi B, Staffa SJ, Benson CB, Buchmiller TL
Fetal Diagn Ther 2021;48(3):235-242. Epub 2021 Mar 17 doi: 10.1159/000512689. PMID: 33730724
López JJ, Lodwick DL, Cooper JN, Hogan M, King D, Minneci PC
J Surg Res 2017 Nov;219:1-4. Epub 2017 May 12 doi: 10.1016/j.jss.2017.05.029. PMID: 29078866
Pelaez CA, Dehning MF
JAMA Surg 2015 Apr;150(4):365-6. doi: 10.1001/jamasurg.2014.852. PMID: 25714037

Therapy

Giurazza F, Marra P, Mosconi C, Corvino F, Corvino A, Niola R
J Clin Ultrasound 2022 Nov;50(9):1360-1367. Epub 2022 Aug 30 doi: 10.1002/jcu.23298. PMID: 36053957
You JH, Lv GR, Liu XL, He SZ
Prenat Diagn 2014 Dec;34(12):1189-97. Epub 2014 Jul 24 doi: 10.1002/pd.4451. PMID: 25042792
Liang ZW, Cheng Y, Jiang ZS, Liu HY, Gao Y, Pan MX
World J Gastroenterol 2014 Jan 7;20(1):258-63. doi: 10.3748/wjg.v20.i1.258. PMID: 24415880Free PMC Article
Liese J, Kohler S, Moench C, Bechstein WO, Ulrich F
Langenbecks Arch Surg 2013 Mar;398(3):449-54. Epub 2013 Feb 6 doi: 10.1007/s00423-013-1054-9. PMID: 23385735
Gumbs AA, Bouhanna P, Bar-Zakai B, Briennon X, Gayet B
J Laparoendosc Adv Surg Tech A 2008 Aug;18(4):611-3. doi: 10.1089/lap.2007.0194. PMID: 18721016

Prognosis

DCunha AR, Rai E, Jacob TJK, Devasia AJ, Rebekah G
Pediatr Surg Int 2022 Oct;38(10):1405-1412. Epub 2022 Jul 29 doi: 10.1007/s00383-022-05182-3. PMID: 35906350
Lazow SP, Richman DM, Dionigi B, Staffa SJ, Benson CB, Buchmiller TL
Fetal Diagn Ther 2021;48(3):235-242. Epub 2021 Mar 17 doi: 10.1159/000512689. PMID: 33730724
López JJ, Lodwick DL, Cooper JN, Hogan M, King D, Minneci PC
J Surg Res 2017 Nov;219:1-4. Epub 2017 May 12 doi: 10.1016/j.jss.2017.05.029. PMID: 29078866
Akhan O, Dagoglu-Kartal MG, Ciftci T, Ozer C, Erbahceci A, Akinci D
Cardiovasc Intervent Radiol 2017 Sep;40(9):1421-1430. Epub 2017 May 1 doi: 10.1007/s00270-017-1650-0. PMID: 28462445
Hodge MG, Ricketts RR, Simoneaux SF, Abramowsky CR, Elawabdeh N, Shehata BM
Fetal Pediatr Pathol 2012 Apr;31(2):54-62. doi: 10.3109/15513815.2011.648725. PMID: 22409406

Clinical prediction guides

Karaaslan B
Eur Rev Med Pharmacol Sci 2023 Sep;27(18):8550-8555. doi: 10.26355/eurrev_202309_33780. PMID: 37782171
Vasilescu AM, Târcoveanu E, Ciuntu B, Fotea V, Georgescu S, Andreea L, Ciobanu DL, Lupascu C, Bradea C
Ann Ital Chir 2022;93:671-679. PMID: 36259435
Zaręba KP, Cummings K, Dorf J, Kamocki Z, Kędra B
Pol Przegl Chir 2022 Jan 26;94(5):9-12. doi: 10.5604/01.3001.0015.7089. PMID: 36169581
DCunha AR, Rai E, Jacob TJK, Devasia AJ, Rebekah G
Pediatr Surg Int 2022 Oct;38(10):1405-1412. Epub 2022 Jul 29 doi: 10.1007/s00383-022-05182-3. PMID: 35906350
Hodge MG, Ricketts RR, Simoneaux SF, Abramowsky CR, Elawabdeh N, Shehata BM
Fetal Pediatr Pathol 2012 Apr;31(2):54-62. doi: 10.3109/15513815.2011.648725. PMID: 22409406

Recent systematic reviews

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