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Glioneuronal Tumor with Neuropil-Like Islands

MedGen UID:
457397
•Concept ID:
C2985171
•
Neoplastic Process

Definition

A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlioneuronal Tumor with Neuropil-Like Islands

Recent clinical studies

Etiology

ATRX loss in glioneuronal tumors with neuropil-like islands indicates similarity to diffuse astrocytic tumors.
Kakkar A, Nambirajan A, Kaur K, Kumar A, Mallick S, Suri V, Sarkar C, Kale SS, Garg A, Sharma MC
J Neurooncol 2016 Oct;130(1):63-68. Epub 2016 Jul 28 doi: 10.1007/s11060-016-2224-8. PMID: 27469217
An individual patient data meta-analysis on characteristics and outcome of patients with papillary glioneuronal tumor, rosette glioneuronal tumor with neuropil-like islands and rosette forming glioneuronal tumor of the fourth ventricle.
Schlamann A, von Bueren AO, Hagel C, Zwiener I, Seidel C, Kortmann RD, Müller K
PLoS One 2014;9(7):e101211. Epub 2014 Jul 3 doi: 10.1371/journal.pone.0101211. PMID: 24991807Free PMC Article
The expanding family of glioneuronal tumors.
Allende DS, Prayson RA
Adv Anat Pathol 2009 Jan;16(1):33-9. doi: 10.1097/PAP.0b013e3181915e3b. PMID: 19098465
Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL
Neuropathology 2009 Oct;29(5):574-8. Epub 2008 Dec 3 doi: 10.1111/j.1440-1789.2008.00988.x. PMID: 19077041

Diagnosis

Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands.
Tsuboi N, Ishida J, Shimazu Y, Edaki H, Uneda A, Otani Y, Fujii K, Kurozumi K, Ennishi D, Yanai H, Date I
Acta Med Okayama 2022 Aug;76(4):473-477. doi: 10.18926/AMO/63907. PMID: 36123163
Glioneuronal tumor with neuropil-like islands in the spinal cord: A case report and literature review.
Liu H, Wang C, Lou L, Li Y, Yi L
Medicine (Baltimore) 2022 May 13;101(19):e29237. doi: 10.1097/MD.0000000000029237. PMID: 35583532Free PMC Article
ATRX loss in glioneuronal tumors with neuropil-like islands indicates similarity to diffuse astrocytic tumors.
Kakkar A, Nambirajan A, Kaur K, Kumar A, Mallick S, Suri V, Sarkar C, Kale SS, Garg A, Sharma MC
J Neurooncol 2016 Oct;130(1):63-68. Epub 2016 Jul 28 doi: 10.1007/s11060-016-2224-8. PMID: 27469217
An individual patient data meta-analysis on characteristics and outcome of patients with papillary glioneuronal tumor, rosette glioneuronal tumor with neuropil-like islands and rosette forming glioneuronal tumor of the fourth ventricle.
Schlamann A, von Bueren AO, Hagel C, Zwiener I, Seidel C, Kortmann RD, Müller K
PLoS One 2014;9(7):e101211. Epub 2014 Jul 3 doi: 10.1371/journal.pone.0101211. PMID: 24991807Free PMC Article
The expanding family of glioneuronal tumors.
Allende DS, Prayson RA
Adv Anat Pathol 2009 Jan;16(1):33-9. doi: 10.1097/PAP.0b013e3181915e3b. PMID: 19098465

Prognosis

Glioneuronal tumor with neuropil-like islands in the spinal cord: A case report and literature review.
Liu H, Wang C, Lou L, Li Y, Yi L
Medicine (Baltimore) 2022 May 13;101(19):e29237. doi: 10.1097/MD.0000000000029237. PMID: 35583532Free PMC Article
An individual patient data meta-analysis on characteristics and outcome of patients with papillary glioneuronal tumor, rosette glioneuronal tumor with neuropil-like islands and rosette forming glioneuronal tumor of the fourth ventricle.
Schlamann A, von Bueren AO, Hagel C, Zwiener I, Seidel C, Kortmann RD, Müller K
PLoS One 2014;9(7):e101211. Epub 2014 Jul 3 doi: 10.1371/journal.pone.0101211. PMID: 24991807Free PMC Article
Disseminated glioneuronal tumor with neuropil-like islands of the spinal cord: a distinctive entity.
Serra SM, Dabdoub CB, da Cunha AH, Salazar B, Lima TP, Azevedo-Filho HC
World Neurosurg 2013 Nov;80(5):655.e1-5. Epub 2013 Feb 9 doi: 10.1016/j.wneu.2013.02.029. PMID: 23403348
Spinal glioneuronal tumor with neuropil-like islands and meningeal dissemination: histopathological and radiological study of a pediatric case.
Poliani PL, Sperli D, Valentini S, Armentano A, Bercich L, Bonetti MF, Corriero G, Brisigotti M, Quattrone A, Lanza PL
Neuropathology 2009 Oct;29(5):574-8. Epub 2008 Dec 3 doi: 10.1111/j.1440-1789.2008.00988.x. PMID: 19077041
Glioneuronal tumor with neuropil-like islands.
Prayson RA, Abramovich CM
Hum Pathol 2000 Nov;31(11):1435-8. PMID: 11112223

Clinical prediction guides

Glial tumors with neuronal differentiation.
Park CK, Phi JH, Park SH
Neurosurg Clin N Am 2015 Jan;26(1):117-38. doi: 10.1016/j.nec.2014.09.006. PMID: 25432191
Cytogenetic study of glioneuronal tumor with neuropil-like islands: a case report.
Min HS, Lee SH, Yoo H, Myung J, Hong EK, Park SH
Neuropathology 2010 Aug;30(4):420-6. Epub 2009 Oct 21 doi: 10.1111/j.1440-1789.2009.01066.x. PMID: 19845863
Glioneuronal tumor with neuropil-like islands.
Prayson RA, Abramovich CM
Hum Pathol 2000 Nov;31(11):1435-8. PMID: 11112223

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