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Cervical intraepithelial neoplasia grade 2/3

MedGen UID:
458848
•Concept ID:
C2986622
•
Neoplastic Process
Synonyms: Cervical Intraepithelial Neoplasia Grade 2/3; cervical intraepithelial neoplasia grade 2/3; CIN 2/3
 
Monarch Initiative: MONDO:0006137

Definition

A neoplastic process in the cervix characterized by morphologic features of both moderate and severe intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical intraepithelial neoplasia grade 2/3

Professional guidelines

PubMed

Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2/3 or Worse in a Cohort Study.
Li X, Rao X, Wei MJ, Lu WG, Xie X, Wang XY
J Natl Compr Canc Netw 2022 Aug;20(8):906-914.e10. doi: 10.6004/jnccn.2022.7032. PMID: 35948040
Risk Assessment of Human Papillomavirus-Positive Cytology-Negative Cervical Cancer Screening in Black and White Women.
Miller DL, Graham A, Davis KE, Kaur H, White M, Maleki Z, Rodriguez EF
Am J Clin Pathol 2022 Mar 3;157(3):399-405. doi: 10.1093/ajcp/aqab129. PMID: 34508551
Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review.
Kietpeerakool C, Kleebkaow P, Srisomboon J
Asian Pac J Cancer Prev 2015;16(13):5153-8. doi: 10.7314/apjcp.2015.16.13.5153. PMID: 26225645

Recent clinical studies

Etiology

High-Intensity Focused Ultrasound for Patients With Cervical Intraepithelial Neoplasia 2/3: A Prospective One-Arm Study.
Liu Y, Wang W, Zhang M, Qu D, Du C, Chen Y, Reng J, Chen L, Liu S, Yang Y, Zhou H
Ultrasound Med Biol 2023 Jan;49(1):375-379. Epub 2022 Oct 22 doi: 10.1016/j.ultrasmedbio.2022.09.020. PMID: 36283939
Risk factors for pathological upgrading in perimenopausal women with cervical intraepithelial neoplasia grade 2/3 following conization.
Jia M, Lan C, Niu J, Liang Y
Medicine (Baltimore) 2022 Oct 28;101(43):e31368. doi: 10.1097/MD.0000000000031368. PMID: 36316892Free PMC Article
Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2/3 or Worse in a Cohort Study.
Li X, Rao X, Wei MJ, Lu WG, Xie X, Wang XY
J Natl Compr Canc Netw 2022 Aug;20(8):906-914.e10. doi: 10.6004/jnccn.2022.7032. PMID: 35948040
Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial.
Sabihi S, Vahedpoor Z, Saraf-Bank S, Nourian M
Eur J Clin Nutr 2022 May;76(5):666-670. Epub 2022 Apr 5 doi: 10.1038/s41430-021-01022-0. PMID: 35383339
Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, Huang CH, Roden RBS, Wu TC, Chang YN, Hung CF
mBio 2021 Jan 19;12(1) doi: 10.1128/mBio.03224-20. PMID: 33468698Free PMC Article

Diagnosis

The 5-year risk of recurrence of grade 2/3 cervical intraepithelial neoplasia after treatment in a population screening programme by human papillomavirus status: A cohort study in central Italy.
Visioli CB, Iossa A, Gorini G, Mantellini P, Lelli L, Auzzi N, Pierro CD, Carozzi FM, Zappa M
J Med Screen 2023 Dec;30(4):191-200. Epub 2023 May 25 doi: 10.1177/09691413231175630. PMID: 37229655
High-Intensity Focused Ultrasound for Patients With Cervical Intraepithelial Neoplasia 2/3: A Prospective One-Arm Study.
Liu Y, Wang W, Zhang M, Qu D, Du C, Chen Y, Reng J, Chen L, Liu S, Yang Y, Zhou H
Ultrasound Med Biol 2023 Jan;49(1):375-379. Epub 2022 Oct 22 doi: 10.1016/j.ultrasmedbio.2022.09.020. PMID: 36283939
Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2/3 or Worse in a Cohort Study.
Li X, Rao X, Wei MJ, Lu WG, Xie X, Wang XY
J Natl Compr Canc Netw 2022 Aug;20(8):906-914.e10. doi: 10.6004/jnccn.2022.7032. PMID: 35948040
Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial.
Sabihi S, Vahedpoor Z, Saraf-Bank S, Nourian M
Eur J Clin Nutr 2022 May;76(5):666-670. Epub 2022 Apr 5 doi: 10.1038/s41430-021-01022-0. PMID: 35383339
Residual disease and HPV persistence after cryotherapy for cervical intraepithelial neoplasia grade 2/3 in HIV-positive women in Kenya.
De Vuyst H, Mugo NR, Franceschi S, McKenzie K, Tenet V, Njoroge J, Rana FS, Sakr SR, Snijders PJ, Chung MH
PLoS One 2014;9(10):e111037. Epub 2014 Oct 24 doi: 10.1371/journal.pone.0111037. PMID: 25343563Free PMC Article

Therapy

Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial.
Sabihi S, Vahedpoor Z, Saraf-Bank S, Nourian M
Eur J Clin Nutr 2022 May;76(5):666-670. Epub 2022 Apr 5 doi: 10.1038/s41430-021-01022-0. PMID: 35383339
Human papillomavirus vaccine effectiveness by age at first vaccination among Japanese women.
Onuki M, Yamamoto K, Yahata H, Kanao H, Yokota H, Kato H, Shimamoto K, Takehara K, Kamiura S, Tsuda N, Takei Y, Shigeta S, Matsumura N, Yoshida H, Motohara T, Watari H, Nakamura K, Ueda A, Tasaka N, Ishikawa M, Hirashima Y, Kudaka W, Taguchi A, Iwata T, Takahashi F, Kukimoto I, Yoshikawa H, Yaegashi N, Matsumoto K; MINT Study Group
Cancer Sci 2022 Apr;113(4):1428-1434. Epub 2022 Feb 2 doi: 10.1111/cas.15270. PMID: 35043515Free PMC Article
Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, Huang CH, Roden RBS, Wu TC, Chang YN, Hung CF
mBio 2021 Jan 19;12(1) doi: 10.1128/mBio.03224-20. PMID: 33468698Free PMC Article
Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection.
Rodríguez AC, Schiffman M, Herrero R, Hildesheim A, Bratti C, Sherman ME, Solomon D, Guillén D, Alfaro M, Morales J, Hutchinson M, Katki H, Cheung L, Wacholder S, Burk RD
J Natl Cancer Inst 2010 Mar 3;102(5):315-24. Epub 2010 Feb 15 doi: 10.1093/jnci/djq001. PMID: 20157096Free PMC Article
Human papillomavirus vaccines versus cervical cancer screening.
Stanley M
Clin Oncol (R Coll Radiol) 2008 Aug;20(6):388-94. Epub 2008 Jun 5 doi: 10.1016/j.clon.2008.04.006. PMID: 18538554

Prognosis

The 5-year risk of recurrence of grade 2/3 cervical intraepithelial neoplasia after treatment in a population screening programme by human papillomavirus status: A cohort study in central Italy.
Visioli CB, Iossa A, Gorini G, Mantellini P, Lelli L, Auzzi N, Pierro CD, Carozzi FM, Zappa M
J Med Screen 2023 Dec;30(4):191-200. Epub 2023 May 25 doi: 10.1177/09691413231175630. PMID: 37229655
Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2/3 or Worse in a Cohort Study.
Li X, Rao X, Wei MJ, Lu WG, Xie X, Wang XY
J Natl Compr Canc Netw 2022 Aug;20(8):906-914.e10. doi: 10.6004/jnccn.2022.7032. PMID: 35948040
Posttreatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3.
Vink FJ, Steenbergen RDM, Kremer WW, Lissenberg-Witte BI, Heideman DAM, Bleeker MCG, van Zummeren M, Breytenbach E, Visser C, Lukhwareni A, Meijer CJLM, Dreyer G
AIDS 2022 Jun 1;36(7):953-961. Epub 2022 Feb 15 doi: 10.1097/QAD.0000000000003197. PMID: 35152224
Residual disease and HPV persistence after cryotherapy for cervical intraepithelial neoplasia grade 2/3 in HIV-positive women in Kenya.
De Vuyst H, Mugo NR, Franceschi S, McKenzie K, Tenet V, Njoroge J, Rana FS, Sakr SR, Snijders PJ, Chung MH
PLoS One 2014;9(10):e111037. Epub 2014 Oct 24 doi: 10.1371/journal.pone.0111037. PMID: 25343563Free PMC Article
Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women.
Azuma Y, Kusumoto-Matsuo R, Takeuchi F, Uenoyama A, Kondo K, Tsunoda H, Nagasaka K, Kawana K, Morisada T, Iwata T, Aoki D, Kukimoto I
Jpn J Clin Oncol 2014 Oct;44(10):910-7. Epub 2014 Aug 24 doi: 10.1093/jjco/hyu112. PMID: 25156680

Clinical prediction guides

The 5-year risk of recurrence of grade 2/3 cervical intraepithelial neoplasia after treatment in a population screening programme by human papillomavirus status: A cohort study in central Italy.
Visioli CB, Iossa A, Gorini G, Mantellini P, Lelli L, Auzzi N, Pierro CD, Carozzi FM, Zappa M
J Med Screen 2023 Dec;30(4):191-200. Epub 2023 May 25 doi: 10.1177/09691413231175630. PMID: 37229655
Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2/3 or Worse in a Cohort Study.
Li X, Rao X, Wei MJ, Lu WG, Xie X, Wang XY
J Natl Compr Canc Netw 2022 Aug;20(8):906-914.e10. doi: 10.6004/jnccn.2022.7032. PMID: 35948040
Regional differences in human papillomavirus type 52 prevalence among Japanese women with cervical intraepithelial neoplasia†.
Kukimoto I, Onuki M, Yamamoto K, Yahata H, Aoki Y, Yokota H, Konnai K, Nio A, Takehara K, Kamiura S, Tsuda N, Takei Y, Shimada M, Nakai H, Yoshida H, Motohara T, Yamazaki H, Nakamura K, Okunomiya A, Tasaka N, Ishikawa M, Hirashima Y, Shimoji Y, Mori M, Iwata T, Takahashi F, Yoshikawa H, Yaegashi N, Matsumoto K; MINT Study Group
Jpn J Clin Oncol 2022 Oct 6;52(10):1242-1247. doi: 10.1093/jjco/hyac127. PMID: 35938523
Posttreatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3.
Vink FJ, Steenbergen RDM, Kremer WW, Lissenberg-Witte BI, Heideman DAM, Bleeker MCG, van Zummeren M, Breytenbach E, Visser C, Lukhwareni A, Meijer CJLM, Dreyer G
AIDS 2022 Jun 1;36(7):953-961. Epub 2022 Feb 15 doi: 10.1097/QAD.0000000000003197. PMID: 35152224
HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia.
Bierkens M, Wilting SM, van Wieringen WN, van de Wiel MA, Ylstra B, Meijer CJ, Snijders PJ, Steenbergen RD
BMC Cancer 2012 Jan 24;12:36. doi: 10.1186/1471-2407-12-36. PMID: 22273477Free PMC Article

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