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Cervical intraepithelial neoplasia

MedGen UID:
60214
Concept ID:
C0206708
Neoplastic Process
Synonyms: Cervical Dysplasia; Cervical Intraepithelial Neoplasia; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasm; Cervical Intraepithelial Neoplasms; Cervix Intraepithelial Neoplasia; Cervix Uteri Intraepithelial Neoplasia; CIN - Cervical intraepithelial neoplasia; Intraepithelial Neoplasia of Cervix; Intraepithelial Neoplasia of Cervix Uteri; Intraepithelial Neoplasia of the Cervix; Intraepithelial Neoplasia of the Cervix Uteri; Intraepithelial Neoplasia of the Uterine Cervix; Intraepithelial Neoplasia of Uterine Cervix; Intraepithelial Neoplasia, Cervical; Intraepithelial Neoplasm, Cervical; Intraepithelial Neoplasms, Cervical; NEOPL CERVICAL INTRAEPITHELIAL; Neoplasia, Cervical Intraepithelial; Neoplasm, Cervical Intraepithelial; Neoplasms, Cervical Intraepithelial; Uterine Cervix Intraepithelial Neoplasia
SNOMED CT: CIN - Cervical intraepithelial neoplasia (285636001); Cervical intraepithelial neoplasia (285636001)
 
HPO: HP:0032242
Monarch Initiative: MONDO:0022394

Definition

A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer. [from HPO]

Conditions with this feature

Monocytopenia with susceptibility to infections
MedGen UID:
481660
Concept ID:
C3280030
Disease or Syndrome
This primary immunodeficiency, designated IMD21, DCML, or MONOMAC, is characterized by profoundly decreased or absent monocytes, B lymphocytes, natural killer (NK) lymphocytes, and circulating and tissue dendritic cells (DCs), with little or no effect on T-cell numbers. Clinical features of IMD21 are variable and include susceptibility to disseminated nontuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. In the absence of cytogenetic abnormalities or overt dysplasia, hypoplastic bone marrow may initially be diagnosed as aplastic anemia. Bone marrow transplantation is the only cure. Some patients may have an increased risk of miscarriage. Both autosomal dominant transmission and sporadic cases occur. Less common manifestations of GATA2 deficiency include lymphedema and sensorineural hearing loss, a phenotype usually termed 'Emberger syndrome' (614038) (summary by Bigley et al. (2011), Hsu et al. (2011), and Spinner et al. (2014)).

Professional guidelines

PubMed

Shen S, Zhang S, Liu P, Wang J, Du H
Cancer Genet 2020 Oct;248-249:25-30. Epub 2020 Sep 22 doi: 10.1016/j.cancergen.2020.09.003. PMID: 32987255
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071
Basu P, Taghavi K, Hu SY, Mogri S, Joshi S
Curr Probl Cancer 2018 Mar-Apr;42(2):129-136. Epub 2018 Jan 11 doi: 10.1016/j.currproblcancer.2018.01.010. PMID: 29428790

Recent clinical studies

Etiology

Tamura D, Sako W, Watanabe R, Shitara A, Saito F, Yamauchi M, Sugita A, Karube A
J Med Virol 2023 May;95(5):e28777. doi: 10.1002/jmv.28777. PMID: 37212300
Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C
BJOG 2021 Feb;128(3):504-514. Epub 2020 Aug 9 doi: 10.1111/1471-0528.16395. PMID: 32619334Free PMC Article
Suchonska B, Gajewska M, Madej A, Wielgoś M
Indian J Cancer 2020 Jan-Mar;57(1):31-35. doi: 10.4103/ijc.IJC_403_18. PMID: 31736469
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
Santesso N, Mustafa RA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Khatib R, Ma B, Mustafa AA, Lloyd N, Wu D, Broutet N, Schünemann HJ
Int J Gynaecol Obstet 2016 Mar;132(3):266-71. Epub 2015 Nov 28 doi: 10.1016/j.ijgo.2015.07.026. PMID: 26643302

Diagnosis

Dockery LE, Soper JT
Obstet Gynecol Surv 2021 Jan;76(1):55-62. doi: 10.1097/OGX.0000000000000857. PMID: 33506879
Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C
BJOG 2021 Feb;128(3):504-514. Epub 2020 Aug 9 doi: 10.1111/1471-0528.16395. PMID: 32619334Free PMC Article
Suchonska B, Gajewska M, Madej A, Wielgoś M
Indian J Cancer 2020 Jan-Mar;57(1):31-35. doi: 10.4103/ijc.IJC_403_18. PMID: 31736469
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
Mitra A, Tzafetas M, Lyons D, Fotopoulou C, Paraskevaidis E, Kyrgiou M
Br J Hosp Med (Lond) 2016 Aug 2;77(8):C118-23. doi: 10.12968/hmed.2016.77.8.C118. PMID: 27487071

Therapy

Arbyn M, Smith SB, Temin S, Sultana F, Castle P; Collaboration on Self-Sampling and HPV Testing
BMJ 2018 Dec 5;363:k4823. doi: 10.1136/bmj.k4823. PMID: 30518635Free PMC Article
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Santesso N, Mustafa RA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Khatib R, Ma B, Mustafa AA, Lloyd N, Wu D, Broutet N, Schünemann HJ
Int J Gynaecol Obstet 2016 Mar;132(3):266-71. Epub 2015 Nov 28 doi: 10.1016/j.ijgo.2015.07.026. PMID: 26643302
FUTURE II Study Group
N Engl J Med 2007 May 10;356(19):1915-27. doi: 10.1056/NEJMoa061741. PMID: 17494925

Prognosis

Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Chang HK, Seo SS, Myong JP, Yu YL, Byun SW
J Gynecol Oncol 2019 May;30(3):e37. doi: 10.3802/jgo.2019.30.e37. PMID: 30887758Free PMC Article
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Ebisch RM, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJ, van den Akker PA, Massuger LF, Bekkers RL
BJOG 2016 Jan;123(1):59-66. Epub 2015 Jul 14 doi: 10.1111/1471-0528.13530. PMID: 26177672

Clinical prediction guides

Lehtinen M, Pimenoff VN, Nedjai B, Louvanto K, Verhoef L, Heideman DAM, El-Zein M, Widschwendter M, Dillner J
Int J Cancer 2023 Mar 15;152(6):1060-1068. Epub 2022 Oct 10 doi: 10.1002/ijc.34286. PMID: 36093582Free PMC Article
Wang H, Jiang Y, Liang Y, Wei L, Zhang W, Li L
BMC Cancer 2022 Apr 4;22(1):362. doi: 10.1186/s12885-022-09452-0. PMID: 35379200Free PMC Article
Sykes PH, Simcock BJ, Innes CR, Harker D, Williman JA, Whitehead M, van der Griend RA, Lawton BA, Hibma M, Fitzgerald P, Dudley NM, Petrich S, Eva L, Bergzoll C, Kathuria J, McPherson G, Tristram A, Faherty J, Hardie D, Robertson A, Robertson V, Pather S, Wrede CD, Gastrell F, Fentiman G, John M, White E, Parker C, Sadler L
Am J Obstet Gynecol 2022 Feb;226(2):222.e1-222.e13. Epub 2021 Sep 14 doi: 10.1016/j.ajog.2021.09.009. PMID: 34534506
Arbyn M, Redman CWE, Verdoodt F, Kyrgiou M, Tzafetas M, Ghaem-Maghami S, Petry KU, Leeson S, Bergeron C, Nieminen P, Gondry J, Reich O, Moss EL
Lancet Oncol 2017 Dec;18(12):1665-1679. Epub 2017 Nov 7 doi: 10.1016/S1470-2045(17)30700-3. PMID: 29126708
Frederiksen ME, Njor S, Lynge E, Rebolj M
Sex Transm Infect 2015 Jun;91(4):248-56. Epub 2014 Dec 15 doi: 10.1136/sextrans-2014-051754. PMID: 25512668

Recent systematic reviews

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Arbyn M, Simon M, de Sanjosé S, Clarke MA, Poljak M, Rezhake R, Berkhof J, Nyaga V, Gultekin M, Canfell K, Wentzensen N
Lancet Oncol 2022 Jul;23(7):950-960. Epub 2022 Jun 13 doi: 10.1016/S1470-2045(22)00294-7. PMID: 35709810
Jentschke M, Kampers J, Becker J, Sibbertsen P, Hillemanns P
Vaccine 2020 Sep 22;38(41):6402-6409. Epub 2020 Aug 4 doi: 10.1016/j.vaccine.2020.07.055. PMID: 32762871
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cárdenas J, Hernándes, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tähtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala I
BMJ 2018 Feb 27;360:k499. doi: 10.1136/bmj.k499. PMID: 29487049Free PMC Article

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