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Pancreatic Mucinous-Cystic Neoplasm, Low Grade

MedGen UID:
459405
•Concept ID:
C2987179
•
Neoplastic Process
Synonyms: Pancreatic Mucinous Cystic Neoplasm with Low Grade Dysplasia; Pancreatic Mucinous Cystic Neoplasm with Low-Grade Dysplasia; Pancreatic Mucinous-Cystic Neoplasm with Low Grade Dysplasia; Pancreatic Mucinous-Cystic Neoplasm, Low-Grade

Definition

A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Mucinous-Cystic Neoplasm, Low Grade

Professional guidelines

PubMed

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications.
Basturk O, Coban I, Adsay NV
Arch Pathol Lab Med 2009 Mar;133(3):423-38. doi: 10.5858/133.3.423. PMID: 19260748
ACG practice guidelines for the diagnosis and management of neoplastic pancreatic cysts.
Khalid A, Brugge W
Am J Gastroenterol 2007 Oct;102(10):2339-49. Epub 2007 Aug 31 doi: 10.1111/j.1572-0241.2007.01516.x. PMID: 17764489

Recent clinical studies

Etiology

Clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection.
Zu G, Chen W, Wu D, Zhang Y, Chen X
BMC Surg 2023 Sep 21;23(1):288. doi: 10.1186/s12893-023-02170-9. PMID: 37735367Free PMC Article
Surveillance of Pancreatic Cystic Neoplasms.
Chhoda A, Schmidt J, Farrell JJ
Gastrointest Endosc Clin N Am 2023 Jul;33(3):613-640. Epub 2023 Apr 24 doi: 10.1016/j.giec.2023.03.010. PMID: 37245939
Diagnostic features of low- and high-grade mucinous neoplasms in pancreatic cyst FNA cytology.
Sigel C, Wei XJ, Agaram N, Sigel K, Raza R, Andrade R, Rao R, Shah P, Soares K, Goyal A
Cancer Cytopathol 2023 May;131(5):325-336. Epub 2023 Jan 17 doi: 10.1002/cncy.22681. PMID: 36650420Free PMC Article
Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification.
Nasca V, Chiaravalli M, Piro G, Esposito A, Salvatore L, Tortora G, Corbo V, Carbone C
Int J Mol Sci 2020 Sep 2;21(17) doi: 10.3390/ijms21176386. PMID: 32887490Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Diagnosis

Clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection.
Zu G, Chen W, Wu D, Zhang Y, Chen X
BMC Surg 2023 Sep 21;23(1):288. doi: 10.1186/s12893-023-02170-9. PMID: 37735367Free PMC Article
Surveillance of Pancreatic Cystic Neoplasms.
Chhoda A, Schmidt J, Farrell JJ
Gastrointest Endosc Clin N Am 2023 Jul;33(3):613-640. Epub 2023 Apr 24 doi: 10.1016/j.giec.2023.03.010. PMID: 37245939
Diagnostic features of low- and high-grade mucinous neoplasms in pancreatic cyst FNA cytology.
Sigel C, Wei XJ, Agaram N, Sigel K, Raza R, Andrade R, Rao R, Shah P, Soares K, Goyal A
Cancer Cytopathol 2023 May;131(5):325-336. Epub 2023 Jan 17 doi: 10.1002/cncy.22681. PMID: 36650420Free PMC Article
Mucinous Pancreatic Cysts: Comparison of Cyst Size and Location in Certain Mucinous Cyst Subgroups.
Köker IH, Elagöz Ş, Gücin Z, Malya FÜ, Şenturk H
Turk J Gastroenterol 2021 Sep;32(9):735-741. doi: 10.5152/tjg.2021.21318. PMID: 34609302Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Therapy

Short-Term Outcomes of Laparoscopic Duodenum-Preserving Total Pancreatic Head Resection Compared with Laparoscopic Pancreaticoduodenectomy for the Management of Pancreatic-Head Benign or Low-Grade Malignant Lesions.
Chen X, Chen W, Zhang Y, An Y, Zhang X
Med Sci Monit 2020 Sep 16;26:e927248. doi: 10.12659/MSM.927248. PMID: 32935663Free PMC Article
Solid pseudopapillary neoplasm of pancreas: Two case reports.
Gurzu S, Bara T, Sincu M, Gabos S, Vlad DM, Bara T Jr, Beres H, Jung I
Medicine (Baltimore) 2019 Jul;98(29):e16455. doi: 10.1097/MD.0000000000016455. PMID: 31335701Free PMC Article
Prevalence and outcomes of cystic lesions of the transplant pancreas: The University of Wisconsin Experience.
Al-Qaoud TM, Martinez EJ, Sollinger HW, Kaufman DB, Redfield RR 3rd, Welch B, Leverson G, Odorico JS
Am J Transplant 2018 Feb;18(2):467-477. Epub 2017 Nov 15 doi: 10.1111/ajt.14540. PMID: 29024476
Patterns of recurrence and long-term outcomes in patients who underwent pancreatectomy for intraductal papillary mucinous neoplasms with high grade dysplasia: implications for surveillance and future management guidelines.
Blackham AU, Doepker MP, Centeno BA, Springett G, Pimiento JM, Malafa M, Hodul PJ
HPB (Oxford) 2017 Jul;19(7):603-610. Epub 2017 May 9 doi: 10.1016/j.hpb.2017.03.007. PMID: 28495434
Vascular endothelial growth factor, a novel and highly accurate pancreatic fluid biomarker for serous pancreatic cysts.
Yip-Schneider MT, Wu H, Dumas RP, Hancock BA, Agaram N, Radovich M, Schmidt CM
J Am Coll Surg 2014 Apr;218(4):608-17. Epub 2013 Dec 24 doi: 10.1016/j.jamcollsurg.2013.12.019. PMID: 24491241

Prognosis

RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification.
Nasca V, Chiaravalli M, Piro G, Esposito A, Salvatore L, Tortora G, Corbo V, Carbone C
Int J Mol Sci 2020 Sep 2;21(17) doi: 10.3390/ijms21176386. PMID: 32887490Free PMC Article
Precursor Lesions of Pancreatic Cancer.
Kim JY, Hong SM
Oncol Res Treat 2018;41(10):603-610. Epub 2018 Sep 28 doi: 10.1159/000493554. PMID: 30269131
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Mucinous cystic neoplasms of the pancreas: update on the surgical pathology and molecular genetics.
Fukushima N, Zamboni G
Semin Diagn Pathol 2014 Nov;31(6):467-474. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.007. PMID: 25441310

Clinical prediction guides

Clinical outcomes of minimally invasive duodenum-preserving pancreatic head resection.
Zu G, Chen W, Wu D, Zhang Y, Chen X
BMC Surg 2023 Sep 21;23(1):288. doi: 10.1186/s12893-023-02170-9. PMID: 37735367Free PMC Article
RNF43 as a predictor of malignant transformation of pancreatic mucinous cystic neoplasm.
Sakihama K, Koga Y, Yamamoto T, Shimada Y, Yamada Y, Kawata J, Shindo K, Nakamura M, Oda Y
Virchows Arch 2022 Jun;480(6):1189-1199. Epub 2022 Jan 23 doi: 10.1007/s00428-022-03277-9. PMID: 35066614
Mucinous Pancreatic Cysts: Comparison of Cyst Size and Location in Certain Mucinous Cyst Subgroups.
Köker IH, Elagöz Ş, Gücin Z, Malya FÜ, Şenturk H
Turk J Gastroenterol 2021 Sep;32(9):735-741. doi: 10.5152/tjg.2021.21318. PMID: 34609302Free PMC Article
Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification.
Nasca V, Chiaravalli M, Piro G, Esposito A, Salvatore L, Tortora G, Corbo V, Carbone C
Int J Mol Sci 2020 Sep 2;21(17) doi: 10.3390/ijms21176386. PMID: 32887490Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

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