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Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

MedGen UID:
459408
•Concept ID:
C2987182
•
Neoplastic Process
Synonyms: Non-Invasive Pancreatic Mucinous Cystic Neoplasm; Noninvasive Pancreatic Mucinous Cystic Neoplasm

Definition

A cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Invasive Pancreatic Mucinous-Cystic Neoplasm

Professional guidelines

PubMed

MRI of mucinous pancreatic cystic lesions: a new updated morphological approach for the differential diagnosis.
Mamone G, Barresi L, Tropea A, Di Piazza A, Miraglia R
Updates Surg 2020 Sep;72(3):617-637. Epub 2020 May 27 doi: 10.1007/s13304-020-00800-y. PMID: 32462610
Patterns of recurrence and long-term outcomes in patients who underwent pancreatectomy for intraductal papillary mucinous neoplasms with high grade dysplasia: implications for surveillance and future management guidelines.
Blackham AU, Doepker MP, Centeno BA, Springett G, Pimiento JM, Malafa M, Hodul PJ
HPB (Oxford) 2017 Jul;19(7):603-610. Epub 2017 May 9 doi: 10.1016/j.hpb.2017.03.007. PMID: 28495434
Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting.
Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang CL, Matthaei H, Offerhaus GJ, Adham M, Bruno MJ, Reid MD, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang KT, Roa JC, Allen P, Fernández-del Castillo C, Jang JY, Klimstra DS, Hruban RH; Members of Verona Consensus Meeting, 2013
Ann Surg 2016 Jan;263(1):162-77. doi: 10.1097/SLA.0000000000001173. PMID: 25775066Free PMC Article

Recent clinical studies

Etiology

Surveillance after resection of non-invasive intraductal papillary mucinous neoplasms (IPMN). A systematic review.
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508
MRI of mucinous pancreatic cystic lesions: a new updated morphological approach for the differential diagnosis.
Mamone G, Barresi L, Tropea A, Di Piazza A, Miraglia R
Updates Surg 2020 Sep;72(3):617-637. Epub 2020 May 27 doi: 10.1007/s13304-020-00800-y. PMID: 32462610
Is It Time to Expand the Role of Total Pancreatectomy for IPMN?
Griffin JF, Poruk KE, Wolfgang CL
Dig Surg 2016;33(4):335-42. Epub 2016 May 25 doi: 10.1159/000445019. PMID: 27215900
Pancreatic cancer.
Kamisawa T, Wood LD, Itoi T, Takaori K
Lancet 2016 Jul 2;388(10039):73-85. Epub 2016 Jan 30 doi: 10.1016/S0140-6736(16)00141-0. PMID: 26830752
Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e93-101. Epub 2011 Jan 19 doi: 10.1016/j.suronc.2010.12.003. PMID: 21251815

Diagnosis

MRI of mucinous pancreatic cystic lesions: a new updated morphological approach for the differential diagnosis.
Mamone G, Barresi L, Tropea A, Di Piazza A, Miraglia R
Updates Surg 2020 Sep;72(3):617-637. Epub 2020 May 27 doi: 10.1007/s13304-020-00800-y. PMID: 32462610
Pancreatic cancer.
Kamisawa T, Wood LD, Itoi T, Takaori K
Lancet 2016 Jul 2;388(10039):73-85. Epub 2016 Jan 30 doi: 10.1016/S0140-6736(16)00141-0. PMID: 26830752
Invasive biliary mucinous cystic neoplasm: a review.
Simo KA, Mckillop IH, Ahrens WA, Martinie JB, Iannitti DA, Sindram D
HPB (Oxford) 2012 Nov;14(11):725-40. Epub 2012 Jul 22 doi: 10.1111/j.1477-2574.2012.00532.x. PMID: 23043661Free PMC Article
Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e93-101. Epub 2011 Jan 19 doi: 10.1016/j.suronc.2010.12.003. PMID: 21251815
An introduction to mucin-producing tumors of the pancreas: why they deserve more attention.
Takada T, Yasuda H, Amano H, Yoshida M, Hijikata H, Takada K
Hepatogastroenterology 1998 Nov-Dec;45(24):1967-72. PMID: 9951849

Therapy

Surveillance after resection of non-invasive intraductal papillary mucinous neoplasms (IPMN). A systematic review.
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508
Patterns of recurrence and long-term outcomes in patients who underwent pancreatectomy for intraductal papillary mucinous neoplasms with high grade dysplasia: implications for surveillance and future management guidelines.
Blackham AU, Doepker MP, Centeno BA, Springett G, Pimiento JM, Malafa M, Hodul PJ
HPB (Oxford) 2017 Jul;19(7):603-610. Epub 2017 May 9 doi: 10.1016/j.hpb.2017.03.007. PMID: 28495434
Is It Time to Expand the Role of Total Pancreatectomy for IPMN?
Griffin JF, Poruk KE, Wolfgang CL
Dig Surg 2016;33(4):335-42. Epub 2016 May 25 doi: 10.1159/000445019. PMID: 27215900
Pancreatic cancer.
Kamisawa T, Wood LD, Itoi T, Takaori K
Lancet 2016 Jul 2;388(10039):73-85. Epub 2016 Jan 30 doi: 10.1016/S0140-6736(16)00141-0. PMID: 26830752
Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms.
Frankel TL, LaFemina J, Bamboat ZM, D'Angelica MI, DeMatteo RP, Fong Y, Kingham TP, Jarnagin WR, Allen PJ
HPB (Oxford) 2013 Oct;15(10):814-21. Epub 2013 Jun 19 doi: 10.1111/hpb.12137. PMID: 23782351Free PMC Article

Prognosis

Pathologic T1 and T2 encapsulated invasive carcinomas arising from mucinous cystic neoplasms of the pancreas have favorable prognosis and might be treated conservatively.
Liang H, Xie W, Lin X, Wang T, Xie J, Wang C, Xiao SY, Guo Y
J Pathol Clin Res 2021 Sep;7(5):507-516. Epub 2021 Jun 1 doi: 10.1002/cjp2.225. PMID: 34062050Free PMC Article
Invasive biliary mucinous cystic neoplasm: a review.
Simo KA, Mckillop IH, Ahrens WA, Martinie JB, Iannitti DA, Sindram D
HPB (Oxford) 2012 Nov;14(11):725-40. Epub 2012 Jul 22 doi: 10.1111/j.1477-2574.2012.00532.x. PMID: 23043661Free PMC Article
Precursor lesions in pancreatic cancer: morphological and molecular pathology.
Scarlett CJ, Salisbury EL, Biankin AV, Kench J
Pathology 2011 Apr;43(3):183-200. doi: 10.1097/PAT.0b013e3283445e3a. PMID: 21436628
Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e93-101. Epub 2011 Jan 19 doi: 10.1016/j.suronc.2010.12.003. PMID: 21251815
An introduction to mucin-producing tumors of the pancreas: why they deserve more attention.
Takada T, Yasuda H, Amano H, Yoshida M, Hijikata H, Takada K
Hepatogastroenterology 1998 Nov-Dec;45(24):1967-72. PMID: 9951849

Clinical prediction guides

Pathologic T1 and T2 encapsulated invasive carcinomas arising from mucinous cystic neoplasms of the pancreas have favorable prognosis and might be treated conservatively.
Liang H, Xie W, Lin X, Wang T, Xie J, Wang C, Xiao SY, Guo Y
J Pathol Clin Res 2021 Sep;7(5):507-516. Epub 2021 Jun 1 doi: 10.1002/cjp2.225. PMID: 34062050Free PMC Article
Genomic characterization of malignant progression in neoplastic pancreatic cysts.
Noë M, Niknafs N, Fischer CG, Hackeng WM, Beleva Guthrie V, Hosoda W, Debeljak M, Papp E, Adleff V, White JR, Luchini C, Pea A, Scarpa A, Butturini G, Zamboni G, Castelli P, Hong SM, Yachida S, Hiraoka N, Gill AJ, Samra JS, Offerhaus GJA, Hoorens A, Verheij J, Jansen C, Adsay NV, Jiang W, Winter J, Albores-Saavedra J, Terris B, Thompson ED, Roberts NJ, Hruban RH, Karchin R, Scharpf RB, Brosens LAA, Velculescu VE, Wood LD
Nat Commun 2020 Aug 14;11(1):4085. doi: 10.1038/s41467-020-17917-8. PMID: 32796935Free PMC Article
Invasive biliary mucinous cystic neoplasm: a review.
Simo KA, Mckillop IH, Ahrens WA, Martinie JB, Iannitti DA, Sindram D
HPB (Oxford) 2012 Nov;14(11):725-40. Epub 2012 Jul 22 doi: 10.1111/j.1477-2574.2012.00532.x. PMID: 23043661Free PMC Article
Precursor lesions in pancreatic cancer: morphological and molecular pathology.
Scarlett CJ, Salisbury EL, Biankin AV, Kench J
Pathology 2011 Apr;43(3):183-200. doi: 10.1097/PAT.0b013e3283445e3a. PMID: 21436628
Primary pancreatic cystic neoplasms revisited: part II. Mucinous cystic neoplasms.
Sakorafas GH, Smyrniotis V, Reid-Lombardo KM, Sarr MG
Surg Oncol 2011 Jun;20(2):e93-101. Epub 2011 Jan 19 doi: 10.1016/j.suronc.2010.12.003. PMID: 21251815

Recent systematic reviews

Surveillance after resection of non-invasive intraductal papillary mucinous neoplasms (IPMN). A systematic review.
Correa-Gallego C, Miyasaka Y, Hozaka Y, Nishino H, Kawamoto M, Vieira DL, Ohtsuka T, Wolfgang C
Pancreatology 2023 Apr;23(3):258-265. Epub 2023 Feb 27 doi: 10.1016/j.pan.2023.02.008. PMID: 36906508

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