Hemoglobin Trait

MedGen UID:: 459439
•Concept ID:: C2987213
•: Disease or Syndrome

Definition

A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHemoglobin Trait

Disorder by Site
- Hematopoietic and Lymphoid System Disorder
  - Hematologic disorder
    - Non-Neoplastic Hematologic and Lymphocytic Disorder
      - Congenital hematological disorder
        Hemoglobinopathy
        Hemoglobin Trait
        Alpha Thalassemia Silent Carrier
        Alpha trait thalassemia
        Sickle cell trait

Professional guidelines

PubMed

Genetic counseling following the detection of hemoglobinopathy trait on the newborn screen is well received, improves knowledge, and relieves anxiety.

Kladny B, Williams A, Gupta A, Gettig EA, Krishnamurti L
Genet Med 2011 Jul;13(7):658-61. doi: 10.1097/GIM.0b013e31821435f7. PMID: 21546841

A fast hemoglobin variant on newborn screening is associated with alpha-thalassemia trait.

Miller ST, Desai N, Pass KA, Rao SP
Clin Pediatr (Phila) 1997 Feb;36(2):75-8. doi: 10.1177/000992289703600203. PMID: 9118593

Factors affecting the follow-up rate of infants with a hemoglobinopathy trait in a newborn screening and follow-up program.

Yang YM, Andrews S, Bright E, Peterson R, Shah A
J Assoc Acad Minor Phys 1990;1(3):83, 86-9. PMID: 2136622

See all (4)

Recent clinical studies

Etiology

Pattern of hemoglobinopathies and thalassemias in upper Assam region of North Eastern India: high performance liquid chromatography studies in 9000 patients.

Baruah MK, Saikia M, Baruah A
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):236-43. doi: 10.4103/0377-4929.134680. PMID: 24943756

Genetic counseling following the detection of hemoglobinopathy trait on the newborn screen is well received, improves knowledge, and relieves anxiety.

Kladny B, Williams A, Gupta A, Gettig EA, Krishnamurti L
Genet Med 2011 Jul;13(7):658-61. doi: 10.1097/GIM.0b013e31821435f7. PMID: 21546841

Blood pressure and other cardiovascular disease risk factors in black adults with sickle cell trait or glucose-6-phosphate dehydrogenase deficiency.

Nwankwo MU, Bunker CH, Ukoli FA, Omene JA, Freeman DT, Vergis EN, Yeh LL, Kuller LH
Genet Epidemiol 1990;7(3):211-8. doi: 10.1002/gepi.1370070305. PMID: 2369999

Newborn screening for hemoglobinopathies in Colorado. The first 10 years.

Githens JH, Lane PA, McCurdy RS, Houston ML, McKinna JD, Cole DM
Am J Dis Child 1990 Apr;144(4):466-70. doi: 10.1001/archpedi.1990.02150280088018. PMID: 2321611

See all (4)

Diagnosis

Pattern of hemoglobinopathies and thalassemias in upper Assam region of North Eastern India: high performance liquid chromatography studies in 9000 patients.

Baruah MK, Saikia M, Baruah A
Indian J Pathol Microbiol 2014 Apr-Jun;57(2):236-43. doi: 10.4103/0377-4929.134680. PMID: 24943756

Genetic counseling following the detection of hemoglobinopathy trait on the newborn screen is well received, improves knowledge, and relieves anxiety.

Kladny B, Williams A, Gupta A, Gettig EA, Krishnamurti L
Genet Med 2011 Jul;13(7):658-61. doi: 10.1097/GIM.0b013e31821435f7. PMID: 21546841

Newborn screening for hemoglobinopathies in Colorado. The first 10 years.

Githens JH, Lane PA, McCurdy RS, Houston ML, McKinna JD, Cole DM
Am J Dis Child 1990 Apr;144(4):466-70. doi: 10.1001/archpedi.1990.02150280088018. PMID: 2321611

Sickle cell trait/hereditary persistence of fetal hemoglobin trait. Misdiagnosis as sickle cell anemia by newborn screening.

Rubin EM, Rowley PT
Am J Dis Child 1979 Dec;133(12):1248-50. doi: 10.1001/archpedi.1979.02130120040007. PMID: 517474

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