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Esophageal Well Differentiated Squamous Cell Carcinoma

MedGen UID:
459480
•Concept ID:
C2987254
•
Neoplastic Process

Definition

An esophageal squamous cell carcinoma characterized by the presence of prominent keratinization and low mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Well Differentiated Squamous Cell Carcinoma

Professional guidelines

PubMed

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations.
ASGE standards of practice committee, Forbes N, Elhanafi SE, Al-Haddad MA, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):271-284. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.015. PMID: 37498266
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence.
Al-Haddad MA, Elhanafi SE, Forbes N, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Ruan Y, Sadeghirad B, Morgan RL, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):285-305.e38. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.030. PMID: 37498265

Recent clinical studies

Therapy

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.
Chen Z, Gao Y, Huang X, Yao Y, Chen K, Zeng S, Mao W
J Pharm Biomed Anal 2021 Apr 15;197:113937. Epub 2021 Feb 5 doi: 10.1016/j.jpba.2021.113937. PMID: 33609949
Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients.
Sohda M, Saito H, Kuriyama K, Yoshida T, Kumakura Y, Honjyo H, Hara K, Ozawa D, Suzuki S, Tanaka N, Sakai M, Miyazaki T, Fukuchi M, Kuwano H
In Vivo 2019 Mar-Apr;33(2):501-506. doi: 10.21873/invivo.11502. PMID: 30804133Free PMC Article
Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.
Schizas D, Mastoraki A, Naar L, Spartalis E, Tsilimigras DI, Karachaliou GS, Bagias G, Moris D
World J Gastroenterol 2018 Nov 7;24(41):4635-4642. doi: 10.3748/wjg.v24.i41.4635. PMID: 30416311Free PMC Article
Esophageal Cancer: Associations With (pN+) Lymph Node Metastases.
Rice TW, Ishwaran H, Hofstetter WL, Schipper PH, Kesler KA, Law S, Lerut EM, Denlinger CE, Salo JA, Scott WJ, Watson TJ, Allen MS, Chen LQ, Rusch VW, Cerfolio RJ, Luketich JD, Duranceau A, Darling GE, Pera M, Apperson-Hansen C, Blackstone EH
Ann Surg 2017 Jan;265(1):122-129. doi: 10.1097/SLA.0000000000001594. PMID: 28009736Free PMC Article

Prognosis

Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer.
Lu D, Wu X, Wu W, Wu S, Li H, Zhang Y, Yan X, Zhai J, Dong X, Feng S, Zhang X, Sun F, Wang S, Cai K
Cell Death Dis 2023 Dec 19;14(12):843. doi: 10.1038/s41419-023-06329-3. PMID: 38114477Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Advanced squamous cell carcinoma in an asymptomatic, large, epiphrenic esophageal diverticulum.
Yoshida T, Hashimoto S, Mizuno KI, Ichikawa H, Yokoyama J, Umezu H, Terai S
Clin J Gastroenterol 2020 Aug;13(4):477-482. Epub 2020 Jan 27 doi: 10.1007/s12328-020-01098-4. PMID: 31989447
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190

Clinical prediction guides

Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer.
Lu D, Wu X, Wu W, Wu S, Li H, Zhang Y, Yan X, Zhai J, Dong X, Feng S, Zhang X, Sun F, Wang S, Cai K
Cell Death Dis 2023 Dec 19;14(12):843. doi: 10.1038/s41419-023-06329-3. PMID: 38114477Free PMC Article
Survival Risk Prediction of Esophageal Squamous Cell Carcinoma Based on BES-LSSVM.
Wang Y, Zhang W, Sun J, Wang L, Song X, Zhao X
Comput Intell Neurosci 2022;2022:3895590. Epub 2022 Jul 6 doi: 10.1155/2022/3895590. PMID: 35845893Free PMC Article
Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression.
Liu T, Zhao X, Lin Y, Luo Q, Zhang S, Xi Y, Chen Y, Lin L, Fan W, Yang J, Ma Y, Maity AK, Huang Y, Wang J, Chang J, Lin D, Teschendorff AE, Wu C
Cancer Res 2022 Jul 18;82(14):2520-2537. doi: 10.1158/0008-5472.CAN-22-0668. PMID: 35536873
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787

Recent systematic reviews

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995

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