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Esophageal Moderately Differentiated Squamous Cell Carcinoma

MedGen UID:
459481
•Concept ID:
C2987255
•
Neoplastic Process

Definition

An esophageal squamous cell carcinoma characterized by the presence of variable morphologic characteristics that include areas of prominent and poor keratinization. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Moderately Differentiated Squamous Cell Carcinoma

Professional guidelines

PubMed

American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations.
ASGE standards of practice committee, Forbes N, Elhanafi SE, Al-Haddad MA, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):271-284. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.015. PMID: 37498266
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence.
Al-Haddad MA, Elhanafi SE, Forbes N, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Ruan Y, Sadeghirad B, Morgan RL, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):285-305.e38. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.030. PMID: 37498265
Multifocal neoplasia and nodal metastases in T1 esophageal carcinoma: implications for endoscopic treatment.
Altorki NK, Lee PC, Liss Y, Meherally D, Korst RJ, Christos P, Mazumdar M, Port JL
Ann Surg 2008 Mar;247(3):434-9. doi: 10.1097/SLA.0b013e318163a2ff. PMID: 18376186

Recent clinical studies

Etiology

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Zhang L, Yang X, Tian Y, Yu Q, Zhou D, Wu Z, Zhao X
Genet Test Mol Biomarkers 2022 Jan;26(1):8-16. doi: 10.1089/gtmb.2021.0089. PMID: 35089073
Expression of CD44 and CD133 stem cell markers in squamous cell carcinoma of esophagus.
Gupta P, Rizvi SZ, Lal N, Gupta V, Srivastav AN, Musa O
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):472-478. doi: 10.4103/IJPM.IJPM_682_20. PMID: 34341256
Clinical, epidemiological, and diagnostic characteristics of esophageal carcinoma in a Pakistani population.
Asghar MS, Khan NA, Kazmi SJH, Hassan M, Rasheed U, Jawed R, Yaseen R, Naqvi SAA
Ann Saudi Med 2021 Mar-Apr;41(2):91-100. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.91. PMID: 33818145Free PMC Article
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787

Diagnosis

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Zhang L, Yang X, Tian Y, Yu Q, Zhou D, Wu Z, Zhao X
Genet Test Mol Biomarkers 2022 Jan;26(1):8-16. doi: 10.1089/gtmb.2021.0089. PMID: 35089073
Expression of CD44 and CD133 stem cell markers in squamous cell carcinoma of esophagus.
Gupta P, Rizvi SZ, Lal N, Gupta V, Srivastav AN, Musa O
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):472-478. doi: 10.4103/IJPM.IJPM_682_20. PMID: 34341256
Clinical, epidemiological, and diagnostic characteristics of esophageal carcinoma in a Pakistani population.
Asghar MS, Khan NA, Kazmi SJH, Hassan M, Rasheed U, Jawed R, Yaseen R, Naqvi SAA
Ann Saudi Med 2021 Mar-Apr;41(2):91-100. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.91. PMID: 33818145Free PMC Article
Advanced squamous cell carcinoma in an asymptomatic, large, epiphrenic esophageal diverticulum.
Yoshida T, Hashimoto S, Mizuno KI, Ichikawa H, Yokoyama J, Umezu H, Terai S
Clin J Gastroenterol 2020 Aug;13(4):477-482. Epub 2020 Jan 27 doi: 10.1007/s12328-020-01098-4. PMID: 31989447

Therapy

Associations of circulating mediators of inflammation, cell regulation and immune response with esophageal squamous cell carcinoma.
Camargo MC, Song M, Ito H, Oze I, Koyanagi YN, Kasugai Y, Rabkin CS, Matsuo K
J Cancer Res Clin Oncol 2021 Oct;147(10):2885-2892. Epub 2021 Jun 14 doi: 10.1007/s00432-021-03687-3. PMID: 34128078
The relation of EGFR expression by immunohistochemical staining and clinical response of combination treatment of nimotuzumab and chemotherapy in esophageal squamous cell carcinoma.
Jia J, Cui Y, Lu M, Wang X, Li J, Li J, Li Y, Zhang X, Gao J, Zhou J, Lu Z, Gong J, Yu J, Sun Z, Liu C, Shen L, Zhang X
Clin Transl Oncol 2016 Jun;18(6):592-8. Epub 2015 Oct 12 doi: 10.1007/s12094-015-1406-8. PMID: 26459251
Resection of a Submucosal Tumor-Like Superficial Carcinoma in Middle Thoracic Esophagus Concomitant with Mucosal Adenocarcinoma and Submucosal Squamous Cell Carcinoma: A Case Report and Review of Literature.
Yamamoto S, Kumaki N, Makuuchi H, Ozawa S, Shimada H, Chino O, Kazuno A, Yasuda S, Tamayama T, Sakai I
Tokai J Exp Clin Med 2015 Sep 20;40(3):96-103. PMID: 26369262
Validation of tissue microarray technology in squamous cell carcinoma of the esophagus.
Boone J, van Hillegersberg R, van Diest PJ, Offerhaus GJ, Rinkes IH, Kate FJ
Virchows Arch 2008 May;452(5):507-14. doi: 10.1007/s00428-008-0602-0. PMID: 18392848Free PMC Article
Morphologic alterations in esophageal squamous cell carcinoma after preoperative high dose rate intraluminal brachytherapy.
Sur M, Sur R, Cooper K, Levin V, Bizos D, Dubazana N
Cancer 1996 Jun 1;77(11):2200-5. doi: 10.1002/(SICI)1097-0142(19960601)77:11<2200::AID-CNCR3>3.0.CO;2-T. PMID: 8635084

Prognosis

Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Zhang L, Yang X, Tian Y, Yu Q, Zhou D, Wu Z, Zhao X
Genet Test Mol Biomarkers 2022 Jan;26(1):8-16. doi: 10.1089/gtmb.2021.0089. PMID: 35089073
CD147 expression lacks prognostic relevance in esophageal cancer.
Küsters N, Grupp K, Grass JK, Bachmann K, Ghadban T, Uzunoglu FG, Tachezy M, Perez D, Reeh M, Izbicki JR, Melling N
J Cancer Res Clin Oncol 2022 Apr;148(4):837-844. Epub 2022 Jan 8 doi: 10.1007/s00432-022-03917-2. PMID: 34997863Free PMC Article
Clinical, epidemiological, and diagnostic characteristics of esophageal carcinoma in a Pakistani population.
Asghar MS, Khan NA, Kazmi SJH, Hassan M, Rasheed U, Jawed R, Yaseen R, Naqvi SAA
Ann Saudi Med 2021 Mar-Apr;41(2):91-100. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.91. PMID: 33818145Free PMC Article
Advanced squamous cell carcinoma in an asymptomatic, large, epiphrenic esophageal diverticulum.
Yoshida T, Hashimoto S, Mizuno KI, Ichikawa H, Yokoyama J, Umezu H, Terai S
Clin J Gastroenterol 2020 Aug;13(4):477-482. Epub 2020 Jan 27 doi: 10.1007/s12328-020-01098-4. PMID: 31989447
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787

Clinical prediction guides

Noninvasive Detection of Esophageal Cancer by the Combination of mSEPT9 and SNCG.
Zhang L, Yang X, Tian Y, Yu Q, Zhou D, Wu Z, Zhao X
Genet Test Mol Biomarkers 2022 Jan;26(1):8-16. doi: 10.1089/gtmb.2021.0089. PMID: 35089073
Expression of CD44 and CD133 stem cell markers in squamous cell carcinoma of esophagus.
Gupta P, Rizvi SZ, Lal N, Gupta V, Srivastav AN, Musa O
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):472-478. doi: 10.4103/IJPM.IJPM_682_20. PMID: 34341256
Nomogram for prediction of lymph node metastasis in patients with superficial esophageal squamous cell carcinoma.
Min BH, Yang JW, Min YW, Baek SY, Kim S, Kim HK, Choi YS, Shim YM, Choi YL, Zo JI
J Gastroenterol Hepatol 2020 Jun;35(6):1009-1015. Epub 2019 Dec 15 doi: 10.1111/jgh.14915. PMID: 31674067
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Clinical implication of endoscopic gross appearance in superficial esophageal squamous carcinoma: revisited.
Huh CW, Jung DH, Kim JH, Ma DW, Youn YH, Park H
Surg Endosc 2018 Jan;32(1):367-375. Epub 2017 Jun 29 doi: 10.1007/s00464-017-5685-8. PMID: 28664436

Recent systematic reviews

Helicobacter pylori eradication for the prevention of gastric neoplasia.
Ford AC, Yuan Y, Forman D, Hunt R, Moayyedi P
Cochrane Database Syst Rev 2020 Jul 6;7(7):CD005583. doi: 10.1002/14651858.CD005583.pub3. PMID: 32628791Free PMC Article

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