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Negative for Gastric Dysplasia

MedGen UID:
459627
•Concept ID:
C2987401
•
Finding
Synonym: Negative for Gastric Intraepithelial Neoplasia

Definition

A morphologic finding indicating the absence of dysplastic changes in the gastric mucosal epithelium. It includes non-neoplastic inflammatory, reactive, or metaplastic pathologic processes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNegative for Gastric Dysplasia

Professional guidelines

PubMed

Differential diagnosis of gastric low- and high grade dysplasia using C6orf15 protein.
Liu L, Wang X, He Q, Yu B, Wang J, Shen H
Ann Diagn Pathol 2024 Aug;71:152298. Epub 2024 Mar 26 doi: 10.1016/j.anndiagpath.2024.152298. PMID: 38547762
Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping.
Quach DT, Hiyama T, Le HM, Nguyen TS, Gotoda T
Scand J Gastroenterol 2020 Apr;55(4):402-407. Epub 2020 Mar 28 doi: 10.1080/00365521.2020.1740777. PMID: 32223458
Barrett's oesophagus diagnostic criteria: endoscopy and histology.
Naini BV, Chak A, Ali MA, Odze RD
Best Pract Res Clin Gastroenterol 2015 Feb;29(1):77-96. Epub 2014 Nov 13 doi: 10.1016/j.bpg.2014.11.004. PMID: 25743458

Recent clinical studies

Therapy

Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer.
Guo Y, Zhang Y, Gerhard M, Gao JJ, Mejias-Luque R, Zhang L, Vieth M, Ma JL, Bajbouj M, Suchanek S, Liu WD, Ulm K, Quante M, Li ZX, Zhou T, Schmid R, Classen M, Li WQ, You WC, Pan KF
Gut 2020 Sep;69(9):1598-1607. Epub 2019 Dec 19 doi: 10.1136/gutjnl-2019-319696. PMID: 31857433Free PMC Article
Helicobacter pylori and Gastric Cancer: Timing and Impact of Preventive Measures.
Venerito M, Vasapolli R, Malfertheiner P
Adv Exp Med Biol 2016;908:409-18. doi: 10.1007/978-3-319-41388-4_20. PMID: 27573783
Helicobacter pylori and Gastrointestinal Malignancies.
Venerito M, Vasapolli R, Rokkas T, Malfertheiner P
Helicobacter 2015 Sep;20 Suppl 1:36-9. doi: 10.1111/hel.12255. PMID: 26372823

Prognosis

Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
Deep learning for automatic diagnosis of gastric dysplasia using whole-slide histopathology images in endoscopic specimens.
Shi Z, Zhu C, Zhang Y, Wang Y, Hou W, Li X, Lu J, Guo X, Xu F, Jiang X, Wang Y, Liu J, Jin M
Gastric Cancer 2022 Jul;25(4):751-760. Epub 2022 Apr 8 doi: 10.1007/s10120-022-01294-w. PMID: 35394573
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Long-term natural history after endoscopic resection for gastric dysplasia.
Kim JL, Kim SG, Lee A, Choi J, Chung H, Cho SJ
Surg Endosc 2021 Sep;35(9):5247-5255. Epub 2020 Sep 28 doi: 10.1007/s00464-020-08023-3. PMID: 32989550
Risk stratification of patients with gastric lesions indefinite for dysplasia.
Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ
Korean J Intern Med 2021 Sep;36(5):1074-1082. Epub 2020 Sep 9 doi: 10.3904/kjim.2018.285. PMID: 32898394Free PMC Article

Clinical prediction guides

Effectiveness and safety of Moluodan in the treatment of precancerous lesions of gastric cancer: A randomized clinical trial.
Zou TH, Gao QY, Liu S, Li YQ, Meng XJ, Zhang GX, Tian ZB, Zou XP, He S, Hou XH, Lin R, Li JN, Zhou ZY, Li Y, Wang MC, Wang BM, Tian A, Chen SJ, Cao Q, Li LP, Wang ZR, Shen XZ, Liu BR, Yan XY, Chen YX, Fang JY
J Dig Dis 2024 Jan;25(1):27-35. Epub 2024 Feb 11 doi: 10.1111/1751-2980.13251. PMID: 38342693
Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
Deep learning for automatic diagnosis of gastric dysplasia using whole-slide histopathology images in endoscopic specimens.
Shi Z, Zhu C, Zhang Y, Wang Y, Hou W, Li X, Lu J, Guo X, Xu F, Jiang X, Wang Y, Liu J, Jin M
Gastric Cancer 2022 Jul;25(4):751-760. Epub 2022 Apr 8 doi: 10.1007/s10120-022-01294-w. PMID: 35394573
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Risk stratification of patients with gastric lesions indefinite for dysplasia.
Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ
Korean J Intern Med 2021 Sep;36(5):1074-1082. Epub 2020 Sep 9 doi: 10.3904/kjim.2018.285. PMID: 32898394Free PMC Article

Recent systematic reviews

Diagnostic accuracy of magnifying chromoendoscopy in the assessment of tumor invasion depth in early colorectal cancer: a systematic review and meta-analysis.
Huang Y, Yang Z, Yao Y, Liu G, Chen R
Tech Coloproctol 2023 Dec;27(12):1155-1167. Epub 2023 Jul 20 doi: 10.1007/s10151-023-02833-y. PMID: 37474693
Helicobacter pylori infection is associated with reduced risk of Barrett's esophagus: a meta-analysis and systematic review.
Du YL, Duan RQ, Duan LP
BMC Gastroenterol 2021 Dec 7;21(1):459. doi: 10.1186/s12876-021-02036-5. PMID: 34876031Free PMC Article

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