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Pre-Excitation Syndrome

MedGen UID:
46059
•Concept ID:
C0032915
•
Disease or Syndrome
Synonyms: Pre Excitation Syndromes; Pre-Excitation Syndromes; Preexcitation Syndrome; Preexcitation Syndromes
 
OMIM®: 194200

Definition

An electrocardiographic finding characterized by a premature activation of the whole or some part of the ventricle. The PR interval is usually shortened and delta waves are frequently present. (CDISC) [from NCI]

Professional guidelines

PubMed

Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Brembilla-Perrot B, Olivier A, Sellal JM, Manenti V, Brembilla A, Villemin T, Admant P, Beurrier D, Bozec E, Girerd N
BMJ Open 2016 May 17;6(5):e010520. doi: 10.1136/bmjopen-2015-010520. PMID: 27188807Free PMC Article
Verapamil in the treatment of PSVT.
Kuhn M
Ann Emerg Med 1981 Oct;10(10):538-44. doi: 10.1016/s0196-0644(81)80013-3. PMID: 7025710

Recent clinical studies

Etiology

Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.
Huizar JF, Kaszala K, Tan A, Koneru J, Mankad P, Kron J, Ellenbogen KA
J Am Coll Cardiol 2023 Mar 28;81(12):1192-1200. doi: 10.1016/j.jacc.2023.01.040. PMID: 36948737
Pre-excitation syndrome presenting with acute myocardial infarction.
Rajendran K, Thankachan A, Sreedharan MK, Salam A
BMJ Case Rep 2022 Jul 20;15(7) doi: 10.1136/bcr-2022-250667. PMID: 35858745Free PMC Article
Assessment of the physical performance in children with asymptomatic pre-excitation.
Książczyk TM, Jaroń A, Pietrzak R, Werner B
Europace 2022 May 3;24(5):855-859. doi: 10.1093/europace/euab171. PMID: 34648619
Are the results of electrophysiological study different in patients with a pre-excitation syndrome, with and without syncope?
Brembilla-Perrot B, Chometon F, Groben L, Tatar C, Luporsi JD, Bertrand J, Huttin O, Beurrier D, Ammar S, Cedano J, Benzaghou N, Andronache M, Valizadeh R, Terrier De La Chaise A, Louis P, Selton O, Claudon O, Marçon F
Europace 2008 Feb;10(2):175-80. doi: 10.1093/europace/eum300. PMID: 18256122
Pre-excitation syndrome and hypertrophic cardiomyopathy.
Perosio AM, Suarez LD, Bunster AM, Locreille A, Apkarian OA, Vallazza MA, Foye R
J Electrocardiol 1983 Jan;16(1):29-40. doi: 10.1016/s0022-0736(83)80156-3. PMID: 6682136

Diagnosis

Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.
Huizar JF, Kaszala K, Tan A, Koneru J, Mankad P, Kron J, Ellenbogen KA
J Am Coll Cardiol 2023 Mar 28;81(12):1192-1200. doi: 10.1016/j.jacc.2023.01.040. PMID: 36948737
Pre-excitation syndrome presenting with acute myocardial infarction.
Rajendran K, Thankachan A, Sreedharan MK, Salam A
BMJ Case Rep 2022 Jul 20;15(7) doi: 10.1136/bcr-2022-250667. PMID: 35858745Free PMC Article
Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Left ventricular dyssynchrony in pre-excitation syndrome: effect of accessory pathway location and reversibility after ablation therapy.
Park HE, Chang SA, Kim JH, Oh IY, Choi EK, Oh S
Heart Vessels 2013 Mar;28(2):199-207. Epub 2012 Feb 21 doi: 10.1007/s00380-012-0233-x. PMID: 22349776
Ventricular pre-excitation.
Ward D
Eur Heart J 1984 Mar;5 Suppl A:119-24. doi: 10.1093/eurheartj/5.suppl_a.119. PMID: 6373270

Therapy

Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Supraventricular tachycardia in infants, children and adolescents: diagnosis, and pharmacological and interventional therapy.
Paul T, Bertram H, Bökenkamp R, Hausdorf G
Paediatr Drugs 2000 May-Jun;2(3):171-81. doi: 10.2165/00128072-200002030-00002. PMID: 10937468
Pre-excitation syndrome in infants and children. Effect of digoxin, verapamil, and amiodarone.
Shahar E, Barzilay Z, Shem-Tov AA, Shohet I, Frand M
Arch Dis Child 1983 Mar;58(3):207-11. doi: 10.1136/adc.58.3.207. PMID: 6838251Free PMC Article
Verapamil in the treatment of PSVT.
Kuhn M
Ann Emerg Med 1981 Oct;10(10):538-44. doi: 10.1016/s0196-0644(81)80013-3. PMID: 7025710
Pre-excitation syndrome.
Zipes DP, Rothbaum DA, DeJoseph RL
Cardiovasc Clin 1974;6(1):209-43. PMID: 4140025

Prognosis

Does the age of evaluation change the long-term follow-up of untreated pre-excitation syndrome?
Brembilla-Perrot B, Vincent J, Olivier A, Bozec E, Girerd N, Sellal JM
J Electrocardiol 2018 Sep-Oct;51(5):792-797. Epub 2018 Jun 19 doi: 10.1016/j.jelectrocard.2018.06.009. PMID: 30177314
Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Brembilla-Perrot B, Olivier A, Sellal JM, Manenti V, Brembilla A, Villemin T, Admant P, Beurrier D, Bozec E, Girerd N
BMJ Open 2016 May 17;6(5):e010520. doi: 10.1136/bmjopen-2015-010520. PMID: 27188807Free PMC Article
Incidence and prognostic significance of spontaneous and inducible antidromic tachycardia.
Brembilla-Perrot B, Pauriah M, Sellal JM, Zinzius PY, Schwartz J, de Chillou C, Cismaru G, Beurrier D, Voilliot D, Selton O, Louis P, Andronache M, Nosu R, de la Chaise AT
Europace 2013 Jun;15(6):871-6. Epub 2012 Nov 12 doi: 10.1093/europace/eus354. PMID: 23148120
Are the results of electrophysiological study different in patients with a pre-excitation syndrome, with and without syncope?
Brembilla-Perrot B, Chometon F, Groben L, Tatar C, Luporsi JD, Bertrand J, Huttin O, Beurrier D, Ammar S, Cedano J, Benzaghou N, Andronache M, Valizadeh R, Terrier De La Chaise A, Louis P, Selton O, Claudon O, Marçon F
Europace 2008 Feb;10(2):175-80. doi: 10.1093/europace/eum300. PMID: 18256122
Pre-excitation syndrome and hypertrophic cardiomyopathy.
Perosio AM, Suarez LD, Bunster AM, Locreille A, Apkarian OA, Vallazza MA, Foye R
J Electrocardiol 1983 Jan;16(1):29-40. doi: 10.1016/s0022-0736(83)80156-3. PMID: 6682136

Clinical prediction guides

Assessment of the physical performance in children with asymptomatic pre-excitation.
Książczyk TM, Jaroń A, Pietrzak R, Werner B
Europace 2022 May 3;24(5):855-859. doi: 10.1093/europace/euab171. PMID: 34648619
Does the age of evaluation change the long-term follow-up of untreated pre-excitation syndrome?
Brembilla-Perrot B, Vincent J, Olivier A, Bozec E, Girerd N, Sellal JM
J Electrocardiol 2018 Sep-Oct;51(5):792-797. Epub 2018 Jun 19 doi: 10.1016/j.jelectrocard.2018.06.009. PMID: 30177314
Left ventricular dyssynchrony in pre-excitation syndrome: effect of accessory pathway location and reversibility after ablation therapy.
Park HE, Chang SA, Kim JH, Oh IY, Choi EK, Oh S
Heart Vessels 2013 Mar;28(2):199-207. Epub 2012 Feb 21 doi: 10.1007/s00380-012-0233-x. PMID: 22349776
Rapid and low-cost method to prove the nature of no documented tachycardia in children and teenagers without pre-excitation syndrome.
Brembilla-Perrot B, Groben L, Chometon F, Lethor JP, Admant P, Cloez JL, Popescu I, Marchal C, Cedano J, Abdelaal A, Huttin O, Tatar C, Benzaghou N, Azman B, Terrier De La Chaise A, Marçon F
Europace 2009 Aug;11(8):1083-9. Epub 2009 Apr 24 doi: 10.1093/europace/eup093. PMID: 19395417
Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation.
Sellers TD Jr, Bashore TM, Gallagher JJ
Circulation 1977 Aug;56(2):260-7. doi: 10.1161/01.cir.56.2.260. PMID: 872319

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