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Pre-Excitation Syndrome

MedGen UID:
46059
•Concept ID:
C0032915
•
Disease or Syndrome
Synonyms: Pre Excitation Syndromes; Pre-Excitation Syndromes; Preexcitation Syndrome; Preexcitation Syndromes
 
OMIM®: 194200

Definition

An electrocardiographic finding characterized by a premature activation of the whole or some part of the ventricle. The PR interval is usually shortened and delta waves are frequently present. (CDISC) [from NCI]

Professional guidelines

PubMed

Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Verapamil in the treatment of PSVT.
Kuhn M
Ann Emerg Med 1981 Oct;10(10):538-44. doi: 10.1016/s0196-0644(81)80013-3. PMID: 7025710
Pre-excitation syndrome: mechanisms and treatment.
Ferrer MI
Cardiovasc Clin 1970;2(2):117-44. PMID: 4131122

Recent clinical studies

Etiology

Pregnancy outcomes in patients complicated with pre-excitation syndrome.
Wang K, Xin J, Hu Q, Wang X, Yu H
Arch Gynecol Obstet 2024 Aug;310(2):1027-1035. Epub 2024 Mar 2 doi: 10.1007/s00404-024-07420-6. PMID: 38431699Free PMC Article
Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.
Huizar JF, Kaszala K, Tan A, Koneru J, Mankad P, Kron J, Ellenbogen KA
J Am Coll Cardiol 2023 Mar 28;81(12):1192-1200. doi: 10.1016/j.jacc.2023.01.040. PMID: 36948737Free PMC Article
Pre-excitation syndrome presenting with acute myocardial infarction.
Rajendran K, Thankachan A, Sreedharan MK, Salam A
BMJ Case Rep 2022 Jul 20;15(7) doi: 10.1136/bcr-2022-250667. PMID: 35858745Free PMC Article
Assessment of the physical performance in children with asymptomatic pre-excitation.
Książczyk TM, Jaroń A, Pietrzak R, Werner B
Europace 2022 May 3;24(5):855-859. doi: 10.1093/europace/euab171. PMID: 34648619
Supraventricular tachycardia in infants, children and adolescents: diagnosis, and pharmacological and interventional therapy.
Paul T, Bertram H, Bökenkamp R, Hausdorf G
Paediatr Drugs 2000 May-Jun;2(3):171-81. doi: 10.2165/00128072-200002030-00002. PMID: 10937468

Diagnosis

Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.
Huizar JF, Kaszala K, Tan A, Koneru J, Mankad P, Kron J, Ellenbogen KA
J Am Coll Cardiol 2023 Mar 28;81(12):1192-1200. doi: 10.1016/j.jacc.2023.01.040. PMID: 36948737Free PMC Article
Pre-excitation syndrome presenting with acute myocardial infarction.
Rajendran K, Thankachan A, Sreedharan MK, Salam A
BMJ Case Rep 2022 Jul 20;15(7) doi: 10.1136/bcr-2022-250667. PMID: 35858745Free PMC Article
Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Targeted next-generation sequencing helps to decipher the genetic and phenotypic heterogeneity of hypertrophic cardiomyopathy.
Cecconi M, Parodi MI, Formisano F, Spirito P, Autore C, Musumeci MB, Favale S, Forleo C, Rapezzi C, Biagini E, Davì S, Canepa E, Pennese L, Castagnetta M, Degiorgio D, Coviello DA
Int J Mol Med 2016 Oct;38(4):1111-24. Epub 2016 Sep 7 doi: 10.3892/ijmm.2016.2732. PMID: 27600940Free PMC Article
Ventricular pre-excitation.
Ward D
Eur Heart J 1984 Mar;5 Suppl A:119-24. doi: 10.1093/eurheartj/5.suppl_a.119. PMID: 6373270

Therapy

Pre-excitation cardiac problems in children: recognition and treatment.
Zhang Y, Li XM
Eur J Pediatr 2020 Aug;179(8):1197-1204. Epub 2020 Jun 11 doi: 10.1007/s00431-020-03701-9. PMID: 32529398
Supraventricular tachycardia in infants, children and adolescents: diagnosis, and pharmacological and interventional therapy.
Paul T, Bertram H, Bökenkamp R, Hausdorf G
Paediatr Drugs 2000 May-Jun;2(3):171-81. doi: 10.2165/00128072-200002030-00002. PMID: 10937468
Verapamil in the treatment of PSVT.
Kuhn M
Ann Emerg Med 1981 Oct;10(10):538-44. doi: 10.1016/s0196-0644(81)80013-3. PMID: 7025710
Pre-excitation syndrome.
Zipes DP, Rothbaum DA, DeJoseph RL
Cardiovasc Clin 1974;6(1):209-43. PMID: 4140025
Pre-excitation syndrome: mechanisms and treatment.
Ferrer MI
Cardiovasc Clin 1970;2(2):117-44. PMID: 4131122

Prognosis

Follow-up of children or teenagers with paroxysmal supraventricular tachycardia, but without pre-excitation syndrome.
Brembilla-Perrot B, Olivier A, Villemin T, Manenti V, Vincent J, Moulin-Zinsch A, Lethor JP, Tisserant A, Marçon F, Jean Marc S
Arch Cardiovasc Dis 2017 Nov;110(11):599-606. Epub 2017 Jul 24 doi: 10.1016/j.acvd.2017.01.013. PMID: 28751003
Incidence and prognostic significance of spontaneous and inducible antidromic tachycardia.
Brembilla-Perrot B, Pauriah M, Sellal JM, Zinzius PY, Schwartz J, de Chillou C, Cismaru G, Beurrier D, Voilliot D, Selton O, Louis P, Andronache M, Nosu R, de la Chaise AT
Europace 2013 Jun;15(6):871-6. Epub 2012 Nov 12 doi: 10.1093/europace/eus354. PMID: 23148120
Are the results of electrophysiological study different in patients with a pre-excitation syndrome, with and without syncope?
Brembilla-Perrot B, Chometon F, Groben L, Tatar C, Luporsi JD, Bertrand J, Huttin O, Beurrier D, Ammar S, Cedano J, Benzaghou N, Andronache M, Valizadeh R, Terrier De La Chaise A, Louis P, Selton O, Claudon O, Marçon F
Europace 2008 Feb;10(2):175-80. doi: 10.1093/europace/eum300. PMID: 18256122
Pre-excitation syndrome and hypertrophic cardiomyopathy.
Perosio AM, Suarez LD, Bunster AM, Locreille A, Apkarian OA, Vallazza MA, Foye R
J Electrocardiol 1983 Jan;16(1):29-40. doi: 10.1016/s0022-0736(83)80156-3. PMID: 6682136
Pre-excitation syndrome: mechanisms and treatment.
Ferrer MI
Cardiovasc Clin 1970;2(2):117-44. PMID: 4131122

Clinical prediction guides

Characteristics of Right-Sided Accessory Pathways Associated With Right Cardiac Veins.
Lai Y, Gao M, Li Q, Li M, Zhang J, Li X, Guo Q, Huang L, Jiang C, Li S, Guo X, Zuo S, Liu N, Wang W, Zhao X, Sang C, Tang R, Long D, Dong J, Ma C
Circ Arrhythm Electrophysiol 2024 May;17(5):e012513. Epub 2024 May 1 doi: 10.1161/CIRCEP.123.012513. PMID: 38690657
Two-dimensional speckle tracking imaging to assess the hazards of left ventricular function and ventricular wall motion disorders in children with pre-excitation syndrome and the efficacy of radiofrequency ablation treatment.
Cheng Z, Liu H, Chen Y, Zhu SL, Yang SW, Chen J
Eur Rev Med Pharmacol Sci 2023 Sep;27(17):7882-7890. doi: 10.26355/eurrev_202309_33545. PMID: 37750616
Assessment of the physical performance in children with asymptomatic pre-excitation.
Książczyk TM, Jaroń A, Pietrzak R, Werner B
Europace 2022 May 3;24(5):855-859. doi: 10.1093/europace/euab171. PMID: 34648619
Does the age of evaluation change the long-term follow-up of untreated pre-excitation syndrome?
Brembilla-Perrot B, Vincent J, Olivier A, Bozec E, Girerd N, Sellal JM
J Electrocardiol 2018 Sep-Oct;51(5):792-797. Epub 2018 Jun 19 doi: 10.1016/j.jelectrocard.2018.06.009. PMID: 30177314
Left ventricular dyssynchrony in pre-excitation syndrome: effect of accessory pathway location and reversibility after ablation therapy.
Park HE, Chang SA, Kim JH, Oh IY, Choi EK, Oh S
Heart Vessels 2013 Mar;28(2):199-207. Epub 2012 Feb 21 doi: 10.1007/s00380-012-0233-x. PMID: 22349776

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