U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alcoholic fatty liver disease

MedGen UID:
4666
•Concept ID:
C0015696
•
Disease or Syndrome
Synonyms: Alcoholic Fatty Liver; Fatty Liver, Alcoholic
SNOMED CT: Alcoholic fatty liver disease (50325005); Alcoholic fatty liver (50325005)
 
Monarch Initiative: MONDO:0021104

Definition

Hepatic steatosis secondary to ethanol consumption. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcoholic fatty liver disease

Professional guidelines

PubMed

Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD).
Rong L, Zou J, Ran W, Qi X, Chen Y, Cui H, Guo J
Front Endocrinol (Lausanne) 2022;13:1087260. Epub 2023 Jan 16 doi: 10.3389/fendo.2022.1087260. PMID: 36726464Free PMC Article
Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis and Natural Products for Prevention and Treatment.
Guo X, Yin X, Liu Z, Wang J
Int J Mol Sci 2022 Dec 7;23(24) doi: 10.3390/ijms232415489. PMID: 36555127Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article

Recent clinical studies

Etiology

Nonalcoholic fatty liver disease: another leap forward.
Abdelmalek MF
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):85-86. doi: 10.1038/s41575-020-00406-0. PMID: 33420415Free PMC Article
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
Eslam M, Sanyal AJ, George J; International Consensus Panel
Gastroenterology 2020 May;158(7):1999-2014.e1. Epub 2020 Feb 8 doi: 10.1053/j.gastro.2019.11.312. PMID: 32044314
Mechanisms of NAFLD development and therapeutic strategies.
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E
Nat Rev Gastroenterol Hepatol 2018 Jan;15(1):11-20. Epub 2017 Sep 20 doi: 10.1038/nrgastro.2017.109. PMID: 28930295
NAFLD: a multisystem disease.
Byrne CD, Targher G
J Hepatol 2015 Apr;62(1 Suppl):S47-64. doi: 10.1016/j.jhep.2014.12.012. PMID: 25920090

Diagnosis

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease.
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, Kleiner DE, Loomba R
Hepatology 2023 May 1;77(5):1797-1835. Epub 2023 Mar 17 doi: 10.1097/HEP.0000000000000323. PMID: 36727674Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Non-alcoholic fatty liver disease.
Maurice J, Manousou P
Clin Med (Lond) 2018 Jun;18(3):245-250. doi: 10.7861/clinmedicine.18-3-245. PMID: 29858436Free PMC Article
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E
Nat Rev Gastroenterol Hepatol 2018 Jan;15(1):11-20. Epub 2017 Sep 20 doi: 10.1038/nrgastro.2017.109. PMID: 28930295
NAFLD: a multisystem disease.
Byrne CD, Targher G
J Hepatol 2015 Apr;62(1 Suppl):S47-64. doi: 10.1016/j.jhep.2014.12.012. PMID: 25920090

Therapy

GLP-1a: Going beyond Traditional Use.
Laurindo LF, Barbalho SM, Guiguer EL, da Silva Soares de Souza M, de Souza GA, Fidalgo TM, Araújo AC, de Souza Gonzaga HF, de Bortoli Teixeira D, de Oliveira Silva Ullmann T, Sloan KP, Sloan LA
Int J Mol Sci 2022 Jan 10;23(2) doi: 10.3390/ijms23020739. PMID: 35054924Free PMC Article
Therapeutic pipeline in nonalcoholic steatohepatitis.
Vuppalanchi R, Noureddin M, Alkhouri N, Sanyal AJ
Nat Rev Gastroenterol Hepatol 2021 Jun;18(6):373-392. Epub 2021 Feb 10 doi: 10.1038/s41575-020-00408-y. PMID: 33568794
Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review.
Zelniker TA, Braunwald E
J Am Coll Cardiol 2020 Feb 4;75(4):422-434. doi: 10.1016/j.jacc.2019.11.031. PMID: 32000955
Mechanisms of NAFLD development and therapeutic strategies.
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article
Treatment of NAFLD with diet, physical activity and exercise.
Romero-Gómez M, Zelber-Sagi S, Trenell M
J Hepatol 2017 Oct;67(4):829-846. Epub 2017 May 23 doi: 10.1016/j.jhep.2017.05.016. PMID: 28545937

Prognosis

Burden of liver diseases in the world.
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.
Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J, Vos MB
Hepatology 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251. PMID: 30179269
Non-alcoholic fatty liver disease.
Maurice J, Manousou P
Clin Med (Lond) 2018 Jun;18(3):245-250. doi: 10.7861/clinmedicine.18-3-245. PMID: 29858436Free PMC Article
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ
Hepatology 2018 Jan;67(1):328-357. Epub 2017 Sep 29 doi: 10.1002/hep.29367. PMID: 28714183
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M
Hepatology 2016 Jul;64(1):73-84. Epub 2016 Feb 22 doi: 10.1002/hep.28431. PMID: 26707365

Clinical prediction guides

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.
Kanwal F, Shubrook JH, Adams LA, Pfotenhauer K, Wai-Sun Wong V, Wright E, Abdelmalek MF, Harrison SA, Loomba R, Mantzoros CS, Bugianesi E, Eckel RH, Kaplan LM, El-Serag HB, Cusi K
Gastroenterology 2021 Nov;161(5):1657-1669. Epub 2021 Sep 20 doi: 10.1053/j.gastro.2021.07.049. PMID: 34602251Free PMC Article
Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.
Eddowes PJ, Sasso M, Allison M, Tsochatzis E, Anstee QM, Sheridan D, Guha IN, Cobbold JF, Deeks JJ, Paradis V, Bedossa P, Newsome PN
Gastroenterology 2019 May;156(6):1717-1730. Epub 2019 Jan 25 doi: 10.1053/j.gastro.2019.01.042. PMID: 30689971
Liver fibrosis markers of nonalcoholic steatohepatitis.
Enomoto H, Bando Y, Nakamura H, Nishiguchi S, Koga M
World J Gastroenterol 2015 Jun 28;21(24):7427-35. doi: 10.3748/wjg.v21.i24.7427. PMID: 26139988Free PMC Article
Non-invasive diagnosis of advanced fibrosis and cirrhosis.
Sharma S, Khalili K, Nguyen GC
World J Gastroenterol 2014 Dec 7;20(45):16820-30. doi: 10.3748/wjg.v20.i45.16820. PMID: 25492996Free PMC Article
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis.
Quek J, Chan KE, Wong ZY, Tan C, Tan B, Lim WH, Tan DJH, Tang ASP, Tay P, Xiao J, Yong JN, Zeng RW, Chew NWS, Nah B, Kulkarni A, Siddiqui MS, Dan YY, Wong VW, Sanyal AJ, Noureddin M, Muthiah M, Ng CH
Lancet Gastroenterol Hepatol 2023 Jan;8(1):20-30. Epub 2022 Nov 16 doi: 10.1016/S2468-1253(22)00317-X. PMID: 36400097
The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis.
Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, Swain MG, Congly SE, Kaplan GG, Shaheen AA
Lancet Gastroenterol Hepatol 2022 Sep;7(9):851-861. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00165-0. PMID: 35798021
The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis.
Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, Qiu Y, Burns L, Afendy A, Nader F
J Hepatol 2019 Oct;71(4):793-801. Epub 2019 Jul 4 doi: 10.1016/j.jhep.2019.06.021. PMID: 31279902
Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis.
Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VW, Kechagias S, Hultcrantz R, Loomba R
Hepatology 2017 May;65(5):1557-1565. Epub 2017 Mar 31 doi: 10.1002/hep.29085. PMID: 28130788Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...