U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Panic disorder with agoraphobia

MedGen UID:
472969
•Concept ID:
C0236800
•
Mental or Behavioral Dysfunction
Synonyms: Panic Disorder with Agoraphobia; panic disorder with agoraphobia
SNOMED CT: Panic disorder with agoraphobia (35607004)
 
Monarch Initiative: MONDO:0044144

Definition

A disorder in which an individual experiences recurrent, unexpected panic attacks and persistent concern about having additional panic attacks. Agoraphobia is a component of this disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPanic disorder with agoraphobia

Professional guidelines

PubMed

Diagnosis and treatment of agoraphobia with panic disorder.
Perugi G, Frare F, Toni C
CNS Drugs 2007;21(9):741-64. doi: 10.2165/00023210-200721090-00004. PMID: 17696574
The history, epidemiology, and differential diagnosis of social anxiety disorder.
Moutier CY, Stein MB
J Clin Psychiatry 1999;60 Suppl 9:4-8. PMID: 10335673
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG, Fletcher KE, Pbert L, Lenderking WR, Santorelli SF
Am J Psychiatry 1992 Jul;149(7):936-43. doi: 10.1176/ajp.149.7.936. PMID: 1609875

Curated

UK NICE Clinical Guideline CG113, Generalised anxiety disorder and panic disorder in adults: management

Recent clinical studies

Etiology

Bipolar disorder comorbidity in patients with obsessive-compulsive disorder: Prevalence and predictors.
Domingues-Castro MS, Torresan RC, Shavitt RG, Fontenelle LF, Ferrão YA, Rosário MC, Torres AR
J Affect Disord 2019 Sep 1;256:324-330. Epub 2019 Jun 7 doi: 10.1016/j.jad.2019.06.018. PMID: 31201983
Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative.
Hamm AO, Richter J, Pané-Farré C, Westphal D, Wittchen HU, Vossbeck-Elsebusch AN, Gerlach AL, Gloster AT, Ströhle A, Lang T, Kircher T, Gerdes AB, Alpers GW, Reif A, Deckert J
Psychophysiology 2016 Mar;53(3):312-22. doi: 10.1111/psyp.12553. PMID: 26877119
Agoraphobia With and Without Panic Disorder: A 20-Year Follow-up of Integrated Exposure and Psychodynamic Therapy.
Hoffart A, Hedley LM, Svanøe K, Langkaas TF, Sexton H
J Nerv Ment Dis 2016 Feb;204(2):100-7. doi: 10.1097/NMD.0000000000000419. PMID: 26588081
Personality disorders and anxiety disorders: what is the relationship?
Latas M, Milovanovic S
Curr Opin Psychiatry 2014 Jan;27(1):57-61. doi: 10.1097/YCO.0000000000000025. PMID: 24270478
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG, Fletcher KE, Pbert L, Lenderking WR, Santorelli SF
Am J Psychiatry 1992 Jul;149(7):936-43. doi: 10.1176/ajp.149.7.936. PMID: 1609875

Diagnosis

Cannabidiol enhancement of exposure therapy in treatment refractory patients with social anxiety disorder and panic disorder with agoraphobia: A randomised controlled trial.
Kwee CM, Baas JM, van der Flier FE, Groenink L, Duits P, Eikelenboom M, van der Veen DC, Moerbeek M, Batelaan NM, van Balkom AJ, Cath DC
Eur Neuropsychopharmacol 2022 Jun;59:58-67. Epub 2022 May 10 doi: 10.1016/j.euroneuro.2022.04.003. PMID: 35561538
Panic attack provocation in panic disorder patients with a computer simulation.
Freire RC, Ferreira-Garcia R, Cabo MC, Martins RM, Nardi AE
J Affect Disord 2020 Mar 1;264:498-505. Epub 2019 Nov 13 doi: 10.1016/j.jad.2019.11.081. PMID: 31786029
Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative.
Hamm AO, Richter J, Pané-Farré C, Westphal D, Wittchen HU, Vossbeck-Elsebusch AN, Gerlach AL, Gloster AT, Ströhle A, Lang T, Kircher T, Gerdes AB, Alpers GW, Reif A, Deckert J
Psychophysiology 2016 Mar;53(3):312-22. doi: 10.1111/psyp.12553. PMID: 26877119
Personality disorders and anxiety disorders: what is the relationship?
Latas M, Milovanovic S
Curr Opin Psychiatry 2014 Jan;27(1):57-61. doi: 10.1097/YCO.0000000000000025. PMID: 24270478
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG, Fletcher KE, Pbert L, Lenderking WR, Santorelli SF
Am J Psychiatry 1992 Jul;149(7):936-43. doi: 10.1176/ajp.149.7.936. PMID: 1609875

Therapy

Self-guided digital treatment with virtual reality for panic disorder and agoraphobia: a study protocol for a randomized controlled trial.
Planert J, Machulska A, Hildebrand AS, Roesmann K, Otto E, Klucken T
Trials 2022 May 21;23(1):426. doi: 10.1186/s13063-022-06366-x. PMID: 35597959Free PMC Article
Cannabidiol enhancement of exposure therapy in treatment refractory patients with social anxiety disorder and panic disorder with agoraphobia: A randomised controlled trial.
Kwee CM, Baas JM, van der Flier FE, Groenink L, Duits P, Eikelenboom M, van der Veen DC, Moerbeek M, Batelaan NM, van Balkom AJ, Cath DC
Eur Neuropsychopharmacol 2022 Jun;59:58-67. Epub 2022 May 10 doi: 10.1016/j.euroneuro.2022.04.003. PMID: 35561538
Cognitive models for panic disorder with agoraphobia: A study of disaggregated within-person effects.
Hoffart A
J Consult Clin Psychol 2016 Sep;84(9):839-844. doi: 10.1037/ccp0000114. PMID: 27123977
Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative.
Hamm AO, Richter J, Pané-Farré C, Westphal D, Wittchen HU, Vossbeck-Elsebusch AN, Gerlach AL, Gloster AT, Ströhle A, Lang T, Kircher T, Gerdes AB, Alpers GW, Reif A, Deckert J
Psychophysiology 2016 Mar;53(3):312-22. doi: 10.1111/psyp.12553. PMID: 26877119
Combination of psychotherapy and benzodiazepines versus either therapy alone for panic disorder: a systematic review.
Watanabe N, Churchill R, Furukawa TA
BMC Psychiatry 2007 May 14;7:18. doi: 10.1186/1471-244X-7-18. PMID: 17501985Free PMC Article

Prognosis

Panic attack provocation in panic disorder patients with a computer simulation.
Freire RC, Ferreira-Garcia R, Cabo MC, Martins RM, Nardi AE
J Affect Disord 2020 Mar 1;264:498-505. Epub 2019 Nov 13 doi: 10.1016/j.jad.2019.11.081. PMID: 31786029
Bipolar disorder comorbidity in patients with obsessive-compulsive disorder: Prevalence and predictors.
Domingues-Castro MS, Torresan RC, Shavitt RG, Fontenelle LF, Ferrão YA, Rosário MC, Torres AR
J Affect Disord 2019 Sep 1;256:324-330. Epub 2019 Jun 7 doi: 10.1016/j.jad.2019.06.018. PMID: 31201983
Cognitive models for panic disorder with agoraphobia: A study of disaggregated within-person effects.
Hoffart A
J Consult Clin Psychol 2016 Sep;84(9):839-844. doi: 10.1037/ccp0000114. PMID: 27123977
Agoraphobia With and Without Panic Disorder: A 20-Year Follow-up of Integrated Exposure and Psychodynamic Therapy.
Hoffart A, Hedley LM, Svanøe K, Langkaas TF, Sexton H
J Nerv Ment Dis 2016 Feb;204(2):100-7. doi: 10.1097/NMD.0000000000000419. PMID: 26588081
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG, Fletcher KE, Pbert L, Lenderking WR, Santorelli SF
Am J Psychiatry 1992 Jul;149(7):936-43. doi: 10.1176/ajp.149.7.936. PMID: 1609875

Clinical prediction guides

Cannabidiol enhancement of exposure therapy in treatment refractory patients with social anxiety disorder and panic disorder with agoraphobia: A randomised controlled trial.
Kwee CM, Baas JM, van der Flier FE, Groenink L, Duits P, Eikelenboom M, van der Veen DC, Moerbeek M, Batelaan NM, van Balkom AJ, Cath DC
Eur Neuropsychopharmacol 2022 Jun;59:58-67. Epub 2022 May 10 doi: 10.1016/j.euroneuro.2022.04.003. PMID: 35561538
Panic attack provocation in panic disorder patients with a computer simulation.
Freire RC, Ferreira-Garcia R, Cabo MC, Martins RM, Nardi AE
J Affect Disord 2020 Mar 1;264:498-505. Epub 2019 Nov 13 doi: 10.1016/j.jad.2019.11.081. PMID: 31786029
Bipolar disorder comorbidity in patients with obsessive-compulsive disorder: Prevalence and predictors.
Domingues-Castro MS, Torresan RC, Shavitt RG, Fontenelle LF, Ferrão YA, Rosário MC, Torres AR
J Affect Disord 2019 Sep 1;256:324-330. Epub 2019 Jun 7 doi: 10.1016/j.jad.2019.06.018. PMID: 31201983
Agoraphobia With and Without Panic Disorder: A 20-Year Follow-up of Integrated Exposure and Psychodynamic Therapy.
Hoffart A, Hedley LM, Svanøe K, Langkaas TF, Sexton H
J Nerv Ment Dis 2016 Feb;204(2):100-7. doi: 10.1097/NMD.0000000000000419. PMID: 26588081
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Kabat-Zinn J, Massion AO, Kristeller J, Peterson LG, Fletcher KE, Pbert L, Lenderking WR, Santorelli SF
Am J Psychiatry 1992 Jul;149(7):936-43. doi: 10.1176/ajp.149.7.936. PMID: 1609875

Recent systematic reviews

Combination of psychotherapy and benzodiazepines versus either therapy alone for panic disorder: a systematic review.
Watanabe N, Churchill R, Furukawa TA
BMC Psychiatry 2007 May 14;7:18. doi: 10.1186/1471-244X-7-18. PMID: 17501985Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG113, Generalised anxiety disorder and panic disorder in adults: management

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...