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Anal Canal Large Cell Neuroendocrine Carcinoma

MedGen UID:
473535
•Concept ID:
C2111706
•
Neoplastic Process
Synonyms: Anal Canal Large Cell NEC; Anal Large Cell NEC; Anal Large Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Recent clinical studies

Etiology

Incidental secondary findings in hemorrhoidectomy specimens: a 16-year experience from a single academic center.
Navale P, Gonzalez RS, Vyas M
Hum Pathol 2021 Mar;109:12-20. Epub 2020 Nov 24 doi: 10.1016/j.humpath.2020.11.008. PMID: 33245989
Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry.
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Neuroendocrine carcinomas of the colon and rectum.
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Diagnosis

Incidental secondary findings in hemorrhoidectomy specimens: a 16-year experience from a single academic center.
Navale P, Gonzalez RS, Vyas M
Hum Pathol 2021 Mar;109:12-20. Epub 2020 Nov 24 doi: 10.1016/j.humpath.2020.11.008. PMID: 33245989
Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry.
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Neuroendocrine carcinomas of the colon and rectum.
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Therapy

Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Prognosis

Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry.
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Neuroendocrine carcinomas of the colon and rectum.
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Clinical prediction guides

Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry.
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283

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