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Colorectal Sarcomatoid Carcinoma

MedGen UID:
474451
•Concept ID:
C3272818
•
Neoplastic Process
Synonyms: Colorectal Carcinoma With Sarcomatoid Components; Colorectal Spindle Cell Carcinoma

Definition

A biphasic colorectal carcinoma with a spindle cell, sarcomatoid component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Sarcomatoid Carcinoma

Professional guidelines

PubMed

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.
Luo C, Cen S, Ding G, Wu W
Cancer Commun (Lond) 2019 Mar 29;39(1):13. doi: 10.1186/s40880-019-0361-0. PMID: 30922401Free PMC Article

Recent clinical studies

Etiology

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Is right-sided colon cancer different to left-sided colorectal cancer? - a systematic review.
Lee GH, Malietzis G, Askari A, Bernardo D, Al-Hassi HO, Clark SK
Eur J Surg Oncol 2015 Mar;41(3):300-8. Epub 2014 Nov 13 doi: 10.1016/j.ejso.2014.11.001. PMID: 25468456
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.
Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA
J Clin Oncol 2003 Oct 15;21(20):3737-43. doi: 10.1200/JCO.2003.04.187. PMID: 14551293

Diagnosis

TRPS1 Expression in Breast Carcinomas: Focusing on Metaplastic Breast Carcinomas.
Parkinson B, Chen W, Shen T, Parwani AV, Li Z
Am J Surg Pathol 2022 Mar 1;46(3):415-423. doi: 10.1097/PAS.0000000000001824. PMID: 35175968
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Pulmonary enteric adenocarcinoma.
Handa Y, Kai Y, Ikeda T, Mukaida H, Egawa H, Kaneko M
Gen Thorac Cardiovasc Surg 2016 Dec;64(12):749-751. Epub 2015 Jul 3 doi: 10.1007/s11748-015-0569-0. PMID: 26139021
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
The prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysis.
Xing X, Cai W, Shi H, Wang Y, Li M, Jiao J, Chen M
Br J Cancer 2013 Jun 25;108(12):2542-8. Epub 2013 May 23 doi: 10.1038/bjc.2013.251. PMID: 23703248Free PMC Article

Therapy

Immunogenic Cell Death: An Emerging Target in Gastrointestinal Cancers.
Chiaravalli M, Spring A, Agostini A, Piro G, Carbone C, Tortora G
Cells 2022 Sep 28;11(19) doi: 10.3390/cells11193033. PMID: 36230995Free PMC Article
Regional Therapy for Colorectal Cancer Liver Metastases: Which Modality and When?
Raphael MJ, Karanicolas PJ
J Clin Oncol 2022 Aug 20;40(24):2806-2817. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02505. PMID: 35649228
Savolitinib: First Approval.
Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Evolving role of regorafenib for the treatment of advanced cancers.
Grothey A, Blay JY, Pavlakis N, Yoshino T, Bruix J
Cancer Treat Rev 2020 Jun;86:101993. Epub 2020 Feb 20 doi: 10.1016/j.ctrv.2020.101993. PMID: 32199197
The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol.
Dhillon HM, van der Ploeg HP, Bell ML, Boyer M, Clarke S, Vardy J
BMC Cancer 2012 Dec 5;12:572. doi: 10.1186/1471-2407-12-572. PMID: 23216897Free PMC Article

Prognosis

Clinicopathological Features and Survival of Signet-Ring Cell Carcinoma and Mucinous Adenocarcinoma of Right Colon, Left Colon, and Rectum.
Zhu L, Ling C, Xu T, Zhang J, Zhang Y, Liu Y, Fang C, Yang L, Zhuang W, Wang R, Ping J, Wang M
Pathol Oncol Res 2021;27:1609800. Epub 2021 Jul 2 doi: 10.3389/pore.2021.1609800. PMID: 34276258Free PMC Article
Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial.
Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893
Clinical and molecular characterization of early-onset colorectal cancer.
Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, Morris VK, Menter D, Broaddus R, Meric-Bernstam F, Hayes-Jordan A, Huh W, Overman MJ, Kopetz S, Loree JM
Cancer 2019 Jun 15;125(12):2002-2010. Epub 2019 Mar 11 doi: 10.1002/cncr.31994. PMID: 30854646Free PMC Article
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Peritoneal carcinomatosis of colorectal origin: Incidence, prognosis and treatment options.
Klaver YL, Lemmens VE, Nienhuijs SW, Luyer MD, de Hingh IH
World J Gastroenterol 2012 Oct 21;18(39):5489-94. doi: 10.3748/wjg.v18.i39.5489. PMID: 23112540Free PMC Article

Clinical prediction guides

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
BRAF V600E mutation-specific antibody: A review.
Ritterhouse LL, Barletta JA
Semin Diagn Pathol 2015 Sep;32(5):400-8. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.010. PMID: 25744437
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
The prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysis.
Xing X, Cai W, Shi H, Wang Y, Li M, Jiao J, Chen M
Br J Cancer 2013 Jun 25;108(12):2542-8. Epub 2013 May 23 doi: 10.1038/bjc.2013.251. PMID: 23703248Free PMC Article

Recent systematic reviews

Health effects of milk consumption: phenome-wide Mendelian randomization study.
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608Free PMC Article
Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Systematic review of blood diagnostic markers in colorectal cancer.
Nikolaou S, Qiu S, Fiorentino F, Rasheed S, Tekkis P, Kontovounisios C
Tech Coloproctol 2018 Jul;22(7):481-498. Epub 2018 Jul 18 doi: 10.1007/s10151-018-1820-3. PMID: 30022330Free PMC Article

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