U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gallbladder Goblet Cell Carcinoid

MedGen UID:
474756
•Concept ID:
C3273123
•
Neoplastic Process

Definition

An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Goblet Cell Carcinoid

Professional guidelines

PubMed

Surgical treatment of neuroendocrine tumors (including carcinoid).
Doherty G
Curr Opin Endocrinol Diabetes Obes 2013 Feb;20(1):32-6. doi: 10.1097/MED.0b013e32835b7efa. PMID: 23183358
Regional treatment of hepatic metastases and hepatocellular carcinoma.
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812
Treatment of secondary hepatic tumours by ligation of hepatic artery and infusion of cytotoxic drugs.
Murray-Lyon IM, Parsons VA, Blendis LM, Dawson JL, Rake MO, Laws JW, Williams R
Lancet 1970 Jul 25;2(7665):172-5. doi: 10.1016/s0140-6736(70)92533-x. PMID: 4193566

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.
Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Prophylactic cholecystectomy in midgut carcinoid patients.
Norlén O, Hessman O, Stålberg P, Akerström G, Hellman P
World J Surg 2010 Jun;34(6):1361-7. doi: 10.1007/s00268-010-0428-1. PMID: 20130865
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program.
Albores-Saavedra J, Batich K, Hossain S, Henson DE, Schwartz AM
Ann Diagn Pathol 2009 Dec;13(6):378-83. doi: 10.1016/j.anndiagpath.2009.08.002. PMID: 19917473
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Incidence and morbidity of cholelithiasis in patients receiving chronic octreotide for metastatic carcinoid and malignant islet cell tumors.
Trendle MC, Moertel CG, Kvols LK
Cancer 1997 Feb 15;79(4):830-4. doi: 10.1002/(sici)1097-0142(19970215)79:4<830::aid-cncr20>3.0.co;2-#. PMID: 9024721

Diagnosis

Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.
Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program.
Albores-Saavedra J, Batich K, Hossain S, Henson DE, Schwartz AM
Ann Diagn Pathol 2009 Dec;13(6):378-83. doi: 10.1016/j.anndiagpath.2009.08.002. PMID: 19917473
Gallbladder carcinoid masquerading as gallbladder carcinoma.
Tewari M, Kumar V, Mishra RR, Shukla HS
Hepatobiliary Pancreat Dis Int 2009 Jun;8(3):326-8. PMID: 19502178
An analysis of rare carcinoid tumors: clarifying these clinical conundrums.
Modlin IM, Shapiro MD, Kidd M
World J Surg 2005 Jan;29(1):92-101. doi: 10.1007/s00268-004-7443-z. PMID: 15599742
Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours.
Tomassetti P, Migliori M, Lalli S, Campana D, Tomassetti V, Corinaldesi R
Ann Oncol 2001;12 Suppl 2:S95-9. doi: 10.1093/annonc/12.suppl_2.s95. PMID: 11762360

Therapy

Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article
Surgical treatment of neuroendocrine tumors (including carcinoid).
Doherty G
Curr Opin Endocrinol Diabetes Obes 2013 Feb;20(1):32-6. doi: 10.1097/MED.0b013e32835b7efa. PMID: 23183358
Incidence and morbidity of cholelithiasis in patients receiving chronic octreotide for metastatic carcinoid and malignant islet cell tumors.
Trendle MC, Moertel CG, Kvols LK
Cancer 1997 Feb 15;79(4):830-4. doi: 10.1002/(sici)1097-0142(19970215)79:4<830::aid-cncr20>3.0.co;2-#. PMID: 9024721
Regional treatment of hepatic metastases and hepatocellular carcinoma.
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812
Abdominal surgery.
Welch CE
N Engl J Med 1969 Feb 20;280(8):419-25 contd. doi: 10.1056/NEJM196902202800805. PMID: 4883944

Prognosis

Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.
Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Primary carcinoid tumor of the gallbladder: a case report and brief review of the literature.
Zou YP, Li WM, Liu HR, Li N
World J Surg Oncol 2010 Feb 23;8:12. doi: 10.1186/1477-7819-8-12. PMID: 20175936Free PMC Article
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program.
Albores-Saavedra J, Batich K, Hossain S, Henson DE, Schwartz AM
Ann Diagn Pathol 2009 Dec;13(6):378-83. doi: 10.1016/j.anndiagpath.2009.08.002. PMID: 19917473
An analysis of rare carcinoid tumors: clarifying these clinical conundrums.
Modlin IM, Shapiro MD, Kidd M
World J Surg 2005 Jan;29(1):92-101. doi: 10.1007/s00268-004-7443-z. PMID: 15599742
Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours.
Tomassetti P, Migliori M, Lalli S, Campana D, Tomassetti V, Corinaldesi R
Ann Oncol 2001;12 Suppl 2:S95-9. doi: 10.1093/annonc/12.suppl_2.s95. PMID: 11762360

Clinical prediction guides

Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome.
Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Ability of FDG-PET/CT in the detection of gallbladder cancer.
Ramos-Font C, Gómez-Rio M, Rodríguez-Fernández A, Jiménez-Heffernan A, Sánchez Sánchez R, Llamas-Elvira JM
J Surg Oncol 2014 Mar;109(3):218-24. Epub 2013 Oct 25 doi: 10.1002/jso.23476. PMID: 24165875
Simultaneous occurrence of metastasizing carcinoid tumour of the gallbladder and chromophobe renal cell carcinoma in a young man.
Morelli L, Piscioli F, Cudazzo E, Del Nonno F, Licci S
Acta Gastroenterol Belg 2007 Oct-Dec;70(4):371-3. PMID: 18330096
Biochemical diagnosis of gastroenteropancreatic endocrine tumors.
Tartaglia A, Bianchini S, Vezzadini P
Minerva Med 2003 Feb;94(1):1-7. PMID: 12719697
Primary carcinoid tumor of the cystic and common bile ducts.
Rugge M, Sonego F, Militello C, Guido M, Ninfo V
Am J Surg Pathol 1992 Aug;16(8):802-7. doi: 10.1097/00000478-199208000-00010. PMID: 1497121

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...