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Small Intestinal Gastrin-Producing Neuroendocrine Tumor

MedGen UID:
475774
Concept ID:
C3274141
Neoplastic Process
Synonyms: Small Intestinal G Cell NET; Small Intestinal Gastrin-Producing NET; Small Intestinal Gastrinoma

Definition

A gastrin-producing neuroendocrine tumor that arises from the small intestine. It is characterized by the presence of uniform cells that form pseudorosettes. The neoplastic cells have uniform nuclei and small amount of eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Gastrin-Producing Neuroendocrine Tumor

Professional guidelines

PubMed

Shao QQ, Zhao BB, Dong LB, Cao HT, Wang WB
World J Gastroenterol 2019 Aug 28;25(32):4673-4681. doi: 10.3748/wjg.v25.i32.4673. PMID: 31528093Free PMC Article
Zandee WT, Brabander T, Blažević A, Kam BLR, Teunissen JJM, Feelders RA, Hofland J, de Herder WW
J Clin Endocrinol Metab 2019 Apr 1;104(4):1336-1344. doi: 10.1210/jc.2018-01991. PMID: 30566620
Virgolini I, Traub-Weidinger T, Decristoforo C
Best Pract Res Clin Endocrinol Metab 2005 Jun;19(2):213-27. doi: 10.1016/j.beem.2004.09.001. PMID: 15763696

Recent clinical studies

Etiology

Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Rico K, Duan S, Pandey RL, Chen Y, Chakrabarti JT, Starr J, Zavros Y, Else T, Katona BW, Metz DC, Merchant JL
BMJ Open Gastroenterol 2021 Nov;8(1) doi: 10.1136/bmjgast-2021-000765. PMID: 34750164Free PMC Article
Sauvanet A
Ann Endocrinol (Paris) 2019 Jun;80(3):175-181. Epub 2019 Apr 11 doi: 10.1016/j.ando.2019.04.009. PMID: 31079831
Corleto VD, Festa S, Di Giulio E, Annibale B
Curr Opin Endocrinol Diabetes Obes 2014 Feb;21(1):3-8. doi: 10.1097/MED.0000000000000031. PMID: 24310148
Klose KJ, Heverhagen JT
Wien Klin Wochenschr 2007;119(19-20):588-92. doi: 10.1007/s00508-007-0886-0. PMID: 17985093

Diagnosis

Sauvanet A
Ann Endocrinol (Paris) 2019 Jun;80(3):175-181. Epub 2019 Apr 11 doi: 10.1016/j.ando.2019.04.009. PMID: 31079831
Corleto VD, Festa S, Di Giulio E, Annibale B
Curr Opin Endocrinol Diabetes Obes 2014 Feb;21(1):3-8. doi: 10.1097/MED.0000000000000031. PMID: 24310148
Rehfeld JF, Gingras MH, Bardram L, Hilsted L, Goetze JP, Poitras P
Gastroenterology 2011 May;140(5):1444-53. Epub 2011 Mar 23 doi: 10.1053/j.gastro.2011.01.051. PMID: 21315717
Klose KJ, Heverhagen JT
Wien Klin Wochenschr 2007;119(19-20):588-92. doi: 10.1007/s00508-007-0886-0. PMID: 17985093
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Therapy

Zandee WT, Brabander T, Blažević A, Kam BLR, Teunissen JJM, Feelders RA, Hofland J, de Herder WW
J Clin Endocrinol Metab 2019 Apr 1;104(4):1336-1344. doi: 10.1210/jc.2018-01991. PMID: 30566620
Kos-Kudła B, Blicharz-Dorniak J, Strzelczyk J, Bałdys-Waligórska A, Bednarczuk T, Bolanowski M, Boratyn-Nowicka A, Borowska M, Cichocki A, Ćwikła JB, Falconi M, Foltyn W, Handkiewicz-Junak D, Hubalewska-Dydejczyk A, Jarząb B, Junik R, Kajdaniuk D, Kamiński G, Kolasińska-Ćwikła A, Kowalska A, Król R, Królicki L, Krzakowski M, Kunikowska J, Kuśnierz K, Lampe P, Lange D, Lewczuk-Myślicka A, Lewiński A, Lipiński M, Londzin-Olesik M, Marek B, Nasierowska-Guttmejer A, Nawrocki S, Nowakowska-Duława E, Pilch-Kowalczyk J, Rosiek V, Ruchała M, Siemińska L, Sowa-Staszczak A, Starzyńska T, Steinhof-Radwańska K, Sworczak K, Syrenicz A, Szawłowski A, Szczepkowski M, Wachuła E, Zajęcki W, Zemczak A, Zgliczyński W, Zieniewicz K
Endokrynol Pol 2017;68(2):79-110. doi: 10.5603/EP.2017.0015. PMID: 28597909
Corleto VD, Festa S, Di Giulio E, Annibale B
Curr Opin Endocrinol Diabetes Obes 2014 Feb;21(1):3-8. doi: 10.1097/MED.0000000000000031. PMID: 24310148
Kos-Kudła B, Blicharz-Dorniak J, Handkiewicz-Junak D, Jarząb B, Jarząb M, Kunikowska J, Kuśnierz K, Król R, Królicki L, Krzakowski M, Nasierowska-Guttmejer A, Nowakowska-Duława E, Patkowski W, Szawłowski AW; Consensus Conference; Polish Network of Neuroendocrine Tumours
Endokrynol Pol 2013;64(6):418-43. doi: 10.5603/EP.2013.0028. PMID: 24431116
Klose KJ, Heverhagen JT
Wien Klin Wochenschr 2007;119(19-20):588-92. doi: 10.1007/s00508-007-0886-0. PMID: 17985093

Prognosis

Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Scherübl H, Streller B, Stabenow R, Herbst H, Höpfner M, Schwertner C, Steinberg J, Eick J, Ring W, Tiwari K, Zappe SM
World J Gastroenterol 2013 Dec 21;19(47):9012-9. doi: 10.3748/wjg.v19.i47.9012. PMID: 24379626Free PMC Article
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL
J Gastrointest Surg 1998 Sep-Oct;2(5):472-82. PMID: 9843608
Reubi JC, Häcki WH, Lamberts SW
J Clin Endocrinol Metab 1987 Dec;65(6):1127-34. doi: 10.1210/jcem-65-6-1127. PMID: 2824549

Clinical prediction guides

Robin L, Sauvanet A, Walter T, Najah H, Falconi M, Pattou F, Gaujoux S; Gastrinoma Surgery Collaborative group
Surgery 2023 May;173(5):1144-1152. Epub 2023 Feb 11 doi: 10.1016/j.surg.2022.12.030. PMID: 36781315
Sauvanet A
Ann Endocrinol (Paris) 2019 Jun;80(3):175-181. Epub 2019 Apr 11 doi: 10.1016/j.ando.2019.04.009. PMID: 31079831
Vanoli A, Albarello L, Uncini S, Fassan M, Grillo F, Di Sabatino A, Martino M, Pasquali C, Milanetto AC, Falconi M, Partelli S, Doglioni C, Schiavo-Lena M, Brambilla T, Pietrabissa A, Sessa F, Capella C, Rindi G, La Rosa S, Solcia E, Paulli M
Am J Surg Pathol 2019 Jun;43(6):725-736. doi: 10.1097/PAS.0000000000001234. PMID: 30913089
Kos-Kudła B, Blicharz-Dorniak J, Handkiewicz-Junak D, Jarząb B, Jarząb M, Kunikowska J, Kuśnierz K, Król R, Królicki L, Krzakowski M, Nasierowska-Guttmejer A, Nowakowska-Duława E, Patkowski W, Szawłowski AW; Consensus Conference; Polish Network of Neuroendocrine Tumours
Endokrynol Pol 2013;64(6):418-43. doi: 10.5603/EP.2013.0028. PMID: 24431116
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL
J Gastrointest Surg 1998 Sep-Oct;2(5):472-82. PMID: 9843608

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