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Opiate Withdrawal Syndrome

MedGen UID:
476135
Concept ID:
C3274502
Mental or Behavioral Dysfunction

Definition

A syndrome that is defined by signs and symptoms related to abrupt or gradual stoppage of opioids use. They include strong cravings, sweating, nausea, vomiting, irritation, anxiety, muscle pain, dilated pupils and insomnia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOpiate Withdrawal Syndrome

Professional guidelines

PubMed

Elias AM, Pepin MJ, Brown JN
J Subst Abuse Treat 2019 Dec;107:38-43. Epub 2019 Oct 20 doi: 10.1016/j.jsat.2019.10.003. PMID: 31757263
Franchitto N, Jullian B, Salles J, Pelissier F, Rolland B
Expert Opin Drug Metab Toxicol 2017 Jun;13(6):669-677. Epub 2017 Apr 3 doi: 10.1080/17425255.2017.1312340. PMID: 28343423
Gossop M
Drug Alcohol Depend 1988 Jul;21(3):253-9. doi: 10.1016/0376-8716(88)90078-6. PMID: 3048954

Recent clinical studies

Therapy

Howell MP, Smith AM, Lindsay EB, Drury SS
J Matern Fetal Neonatal Med 2021 Apr;34(7):1161-1166. Epub 2019 Jun 14 doi: 10.1080/14767058.2019.1627316. PMID: 31195865
Devlin LA, Davis JM
Am J Perinatol 2018 Mar;35(4):324-330. Epub 2017 Nov 3 doi: 10.1055/s-0037-1608630. PMID: 29100261
Franchitto N, Jullian B, Salles J, Pelissier F, Rolland B
Expert Opin Drug Metab Toxicol 2017 Jun;13(6):669-677. Epub 2017 Apr 3 doi: 10.1080/17425255.2017.1312340. PMID: 28343423
Gossop M
Drug Alcohol Depend 1988 Jul;21(3):253-9. doi: 10.1016/0376-8716(88)90078-6. PMID: 3048954
Cushman P Jr
Adv Alcohol Subst Abuse 1987;7(1):17-28. PMID: 3327372

Prognosis

Lacroix A, Puybaret V, Villéger P, Zattoni-Leroy J, Cantaloube S, Chevalier C, Nubukpo P
Therapie 2024 May-Jun;79(3):307-317. Epub 2023 Jul 26 doi: 10.1016/j.therap.2023.07.006. PMID: 37625937
Derbel I, Ghorbel A, Akrout FM, Zahaf A
Afr Health Sci 2016 Dec;16(4):1067-1077. doi: 10.4314/ahs.v16i4.24. PMID: 28479900Free PMC Article
de Wet C, Reed L, Glasper A, Moran P, Bearn J, Gossop M
Drug Alcohol Depend 2004 Oct 5;76(1):31-5. doi: 10.1016/j.drugalcdep.2004.04.002. PMID: 15380286
Wolfhagen FH, Sternieri E, Hop WC, Vitale G, Bertolotti M, Van Buuren HR
Gastroenterology 1997 Oct;113(4):1264-9. doi: 10.1053/gast.1997.v113.pm9322521. PMID: 9322521
Gossop M, Bradley B, Phillips GT
Addict Behav 1987;12(1):1-6. doi: 10.1016/0306-4603(87)90002-5. PMID: 3565107

Clinical prediction guides

Lappen JR, Stark S, Bailit JL, Gibson KS
Am J Obstet Gynecol MFM 2020 Feb;2(1):100075. Epub 2019 Dec 10 doi: 10.1016/j.ajogmf.2019.100075. PMID: 33345989
Derbel I, Ghorbel A, Akrout FM, Zahaf A
Afr Health Sci 2016 Dec;16(4):1067-1077. doi: 10.4314/ahs.v16i4.24. PMID: 28479900Free PMC Article
de Wet C, Reed L, Glasper A, Moran P, Bearn J, Gossop M
Drug Alcohol Depend 2004 Oct 5;76(1):31-5. doi: 10.1016/j.drugalcdep.2004.04.002. PMID: 15380286
Gallimberti L, Spella MR, Soncini CA, Gessa GL
Alcohol 2000 Apr;20(3):257-62. doi: 10.1016/s0741-8329(99)00089-0. PMID: 10869867
Cushman P Jr
Adv Alcohol Subst Abuse 1987;7(1):17-28. PMID: 3327372

Supplemental Content

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    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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