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Acute retinal necrosis syndrome

MedGen UID:
48434
•Concept ID:
C0035319
•
Disease or Syndrome
Synonyms: Acute Retinal Necroses; Acute Retinal Necrosis; Necroses, Acute Retinal; Necrosis, Acute Retinal; Retinal Necroses, Acute; Retinal Necrosis Syndrome, Acute; Retinal Necrosis, Acute
SNOMED CT: Acute retinal necrosis (231986000); ARN - Acute retinal necrosis (231986000); BARN - Bilateral acute retinal necrosis (231986000)
 
Monarch Initiative: MONDO:0006638

Definition

Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute retinal necrosis syndrome

Professional guidelines

PubMed

Classification Criteria for Acute Retinal Necrosis Syndrome.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:237-244. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.057. PMID: 33845012Free PMC Article
Treatment of acute retinal necrosis syndrome.
Aizman A
Drugs Today (Barc) 2006 Aug;42(8):545-51. doi: 10.1358/dot.2006.42.8.1021519. PMID: 16969431
Acute retinal necrosis syndrome: findings, management, and differential diagnosis.
Freilich JM, Ryan EA, Lou PL, Kroll AJ, Brockhurst RJ, Harooni M
Int Ophthalmol Clin 1996 Summer;36(3):141-6. doi: 10.1097/00004397-199603630-00013. PMID: 8989606

Recent clinical studies

Etiology

Antiviral treatment for acute retinal necrosis: A systematic review and meta-analysis.
Putera I, Ridwan AS, Dewi M, Cifuentes-González C, Rojas-Carabali W, Sitompul R, Edwar L, Susiyanti M, Aziza Y, Pavesio C, Chee SP, Mahendradas P, Biswas J, Kempen JH, Gupta V, de-la-Torre A, La Distia Nora R, Agrawal R
Surv Ophthalmol 2024 Jan-Feb;69(1):67-84. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.004. PMID: 37774799
Posterior Herpetic Uveitis: A Comprehensive Review.
Servillo A, Berni A, Marchese A, Bodaghi B, Khairallah M, Read RW, Miserocchi E
Ocul Immunol Inflamm 2023 Sep;31(7):1461-1472. Epub 2023 Jun 26 doi: 10.1080/09273948.2023.2221338. PMID: 37364039
RECURRENT ACUTE RETINAL NECROSIS.
Spaide RF, Byun SS
Retin Cases Brief Rep 2022 Nov 1;16(6):667-669. doi: 10.1097/ICB.0000000000001107. PMID: 33346624
Classification Criteria for Acute Retinal Necrosis Syndrome.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:237-244. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.057. PMID: 33845012Free PMC Article
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044

Diagnosis

Acute retinal necrosis.
Thawley J, Colbert C, Eilbert W
Am J Emerg Med 2024 Aug;82:216.e1-216.e3. Epub 2024 May 22 doi: 10.1016/j.ajem.2024.05.017. PMID: 38806298
Classification Criteria for Acute Retinal Necrosis Syndrome.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:237-244. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.057. PMID: 33845012Free PMC Article
HIV-induced Retinitis.
Wons J, Kempen J, Garweg JG
Ocul Immunol Inflamm 2020 Nov 16;28(8):1259-1268. Epub 2020 Sep 23 doi: 10.1080/09273948.2020.1808225. PMID: 32966142
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044
Acute retinal necrosis.
Bonfioli AA, Eller AW
Semin Ophthalmol 2005 Jul-Sep;20(3):155-60. doi: 10.1080/08820530500232027. PMID: 16282149

Therapy

Acute retinal necrosis.
Thawley J, Colbert C, Eilbert W
Am J Emerg Med 2024 Aug;82:216.e1-216.e3. Epub 2024 May 22 doi: 10.1016/j.ajem.2024.05.017. PMID: 38806298
Antiviral treatment for acute retinal necrosis: A systematic review and meta-analysis.
Putera I, Ridwan AS, Dewi M, Cifuentes-González C, Rojas-Carabali W, Sitompul R, Edwar L, Susiyanti M, Aziza Y, Pavesio C, Chee SP, Mahendradas P, Biswas J, Kempen JH, Gupta V, de-la-Torre A, La Distia Nora R, Agrawal R
Surv Ophthalmol 2024 Jan-Feb;69(1):67-84. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.004. PMID: 37774799
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044
Necrotizing herpetic retinitis.
Cunningham ET Jr, Wong RW, Takakura A, Downes KM, Zierhut M
Ocul Immunol Inflamm 2014 Jun;22(3):167-9. doi: 10.3109/09273948.2014.925378. PMID: 24856278
Acute retinal necrosis.
Lightman S
Br J Ophthalmol 1991 Aug;75(8):449. doi: 10.1136/bjo.75.8.449. PMID: 1873260Free PMC Article

Prognosis

Clinical characteristics and management outcomes of acute retinal necrosis.
Shiezadeh E, Hosseini SM, Bakhtiari E, Mojarrad A, Motamed Shariati M
Sci Rep 2023 Oct 7;13(1):16927. doi: 10.1038/s41598-023-44310-4. PMID: 37805622Free PMC Article
Necrotizing herpetic retinitis.
Cunningham ET Jr, Wong RW, Takakura A, Downes KM, Zierhut M
Ocul Immunol Inflamm 2014 Jun;22(3):167-9. doi: 10.3109/09273948.2014.925378. PMID: 24856278
Herpetic retinitis.
Cordero-Coma M, Anzaar F, Yilmaz T, Foster CS
Herpes 2007 Jun;14(1):4-10. PMID: 17848212
Acute retinal necrosis.
Kezuka T, Atherton SS
Chem Immunol Allergy 2007;92:244-253. doi: 10.1159/000099275. PMID: 17264500
Acute retinal necrosis.
Lightman S
Br J Ophthalmol 1991 Aug;75(8):449. doi: 10.1136/bjo.75.8.449. PMID: 1873260Free PMC Article

Clinical prediction guides

Antiviral treatment for acute retinal necrosis: A systematic review and meta-analysis.
Putera I, Ridwan AS, Dewi M, Cifuentes-González C, Rojas-Carabali W, Sitompul R, Edwar L, Susiyanti M, Aziza Y, Pavesio C, Chee SP, Mahendradas P, Biswas J, Kempen JH, Gupta V, de-la-Torre A, La Distia Nora R, Agrawal R
Surv Ophthalmol 2024 Jan-Feb;69(1):67-84. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.004. PMID: 37774799
Acute retinal necrosis: clinical features, management and outcomes.
Ozdemir Yalcinsoy K, Cakar Ozdal P, Inanc Tekin M, Karatepe MS, Ozdamar Erol Y
Int Ophthalmol 2023 Jun;43(6):1987-1994. Epub 2022 Nov 27 doi: 10.1007/s10792-022-02598-7. PMID: 36436167
Acute retinal necrosis: pathophysiological aspects, diagnosis, and treatment.
Mitkova-Hristova V, Stoyanova NS
Folia Med (Plovdiv) 2022 Dec 31;64(6):871-877. doi: 10.3897/folmed.64.e68036. PMID: 36876564
Risk Factors for Retinal Detachment in Acute Retinal Necrosis.
Bavinger JC, Anthony CL, Lindeke-Myers AT, Lynch S, Xu LT, Barnett J, Levine D, Patel P, Shah R, Jain N, Rao P, Hendrick A, Cribbs BE, Yan J, Hubbard GB 3rd, Shantha JG, O'Keefe GD, Yeh S
Ophthalmol Retina 2022 Jun;6(6):478-483. Epub 2022 Feb 1 doi: 10.1016/j.oret.2022.01.016. PMID: 35114414
Cytopathology of Vitreous Specimens in Acute Retinal Necrosis.
Hojjatie SL, Shantha JG, O'Keefe GD, Kraft CS, Voloschin A, Grossniklaus H, Yeh S
Ocul Immunol Inflamm 2022 Oct-Nov;30(7-8):1609-1616. Epub 2021 Jul 9 doi: 10.1080/09273948.2021.1922926. PMID: 34242097Free PMC Article

Recent systematic reviews

Antiviral treatment for acute retinal necrosis: A systematic review and meta-analysis.
Putera I, Ridwan AS, Dewi M, Cifuentes-González C, Rojas-Carabali W, Sitompul R, Edwar L, Susiyanti M, Aziza Y, Pavesio C, Chee SP, Mahendradas P, Biswas J, Kempen JH, Gupta V, de-la-Torre A, La Distia Nora R, Agrawal R
Surv Ophthalmol 2024 Jan-Feb;69(1):67-84. Epub 2023 Sep 27 doi: 10.1016/j.survophthal.2023.09.004. PMID: 37774799
EFFICIENCY OF LASER PHOTOCOAGULATION ON THE PREVENTION OF RETINAL DETACHMENT IN ACUTE RETINAL NECROSIS: A Systematic Review and Meta-Analysis.
Chen M, Zhang M, Chen H
Retina 2022 Sep 1;42(9):1702-1708. doi: 10.1097/IAE.0000000000003527. PMID: 35576609
Efficacy of prophylactic laser retinopexy in acute retinal necrosis: A systematic review and meta-analysis.
Fan S, Lin D, Wu R, Wang Y
Int Ophthalmol 2022 May;42(5):1651-1660. Epub 2022 Mar 21 doi: 10.1007/s10792-021-02131-2. PMID: 35307785
Role of Prophylactic Vitrectomy in Acute Retinal Necrosis in Preventing Rhegmatogenous Retinal Detachment: Systematic Review and Meta-analysis.
Fan S, Lin D, Wang Y
Ocul Immunol Inflamm 2022 Feb 17;30(2):515-519. Epub 2020 Sep 23 doi: 10.1080/09273948.2020.1800051. PMID: 32966153
RETINAL DETACHMENT AFTER ACUTE RETINAL NECROSIS AND THE EFFICACIES OF DIFFERENT INTERVENTIONS: A Systematic Review and Metaanalysis.
Zhao XY, Meng LH, Zhang WF, Wang DY, Chen YX
Retina 2021 May 1;41(5):965-978. doi: 10.1097/IAE.0000000000002971. PMID: 32932382

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