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Necrotizing sialometaplasia

MedGen UID:
48659
•Concept ID:
C0037033
•
Disease or Syndrome
Synonyms: Necrotizing Sialometaplasia; Necrotizing Sialometaplasias; Sialometaplasia, Necrotizing; Sialometaplasias, Necrotizing
SNOMED CT: Necrotizing sialometaplasia (109769000)
 
Monarch Initiative: MONDO:0006864

Definition

A benign, inflammatory, variably ulcerated, occasionally bilateral, self-healing lesion of the minor salivary glands that is often confused clinically and histologically with carcinoma. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrotizing sialometaplasia

Professional guidelines

PubMed

Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma.
Dadfarnia T, Mohammed BS, Eltorky MA
Ann Diagn Pathol 2012 Jun;16(3):171-6. Epub 2011 Dec 24 doi: 10.1016/j.anndiagpath.2011.08.011. PMID: 22197541

Recent clinical studies

Etiology

Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.
Zhurakivska K, Maiorano E, Nocini R, Mignogna MD, Favia G, Troiano G, Arena C, Caponio VCA, Lo Muzio L
Oral Dis 2019 May;25(4):1084-1090. Epub 2019 Mar 5 doi: 10.1111/odi.13066. PMID: 30776173
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report.
Gilowski Ł, Wiench R, Polakiewicz-Gilowska A, Dwornicka K
Am J Otolaryngol 2014 May-Jun;35(3):400-1. Epub 2014 Mar 11 doi: 10.1016/j.amjoto.2014.03.001. PMID: 24667056
Subacute necrotizing sialadenitis: a clinicopathological study.
Suresh L, Aguirre A
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Sep;104(3):385-90. Epub 2006 Dec 4 doi: 10.1016/j.tripleo.2006.08.012. PMID: 17142073
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102
Necrotizing sialometaplasia.
Penner CR, Thompson LD
Ear Nose Throat J 2003 Jul;82(7):493-4. PMID: 12955830

Diagnosis

Top 10 Nested Pattern Head and Neck Lesions to Notice.
Lott Limbach A, Chute DJ
Head Neck Pathol 2023 Mar;17(1):119-131. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01534-0. PMID: 36928740Free PMC Article
Ulcerative and Inflammatory Lesions of the Oral Mucosa.
Philipone EM, Peters SM
Oral Maxillofac Surg Clin North Am 2023 May;35(2):219-226. Epub 2023 Feb 15 doi: 10.1016/j.coms.2022.10.001. PMID: 36805903
Necrotizing sialometaplasia: A report of two cases and review of the literature.
Medeiros MRS, Barros CCDS, Miguel MCDC, da Silveira ÉJD, de Oliveira PT
Stomatologija 2022;24(2):56-60. PMID: 37140239
Review of the literature on necrotizing sialometaplasia and case presentation.
Ledesma-Montes C, Garcés-Ortíz M, Salcido-García JF, Hernández-Flores F
Quintessence Int 2015 Jan;46(1):67-72. doi: 10.3290/j.qi.a32633. PMID: 25191669
Necrotizing sialometaplasia.
Penner CR, Thompson LD
Ear Nose Throat J 2003 Jul;82(7):493-4. PMID: 12955830

Therapy

Necrotizing sialometaplasia of the palate in a young bodybuilder with anabolic androgenic steroids abuse.
Abdalla-Aslan R, Frid H, Totri A, Akrish S, Merhav G, Rachmiel A
Quintessence Int 2020;51(6):496-501. doi: 10.3290/j.qi.a44146. PMID: 32080687
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature.
Janner SF, Suter VG, Altermatt HJ, Reichart PA, Bornstein MM
Quintessence Int 2014 May;45(5):431-7. doi: 10.3290/j.qi.a31543. PMID: 24634907
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma.
Dadfarnia T, Mohammed BS, Eltorky MA
Ann Diagn Pathol 2012 Jun;16(3):171-6. Epub 2011 Dec 24 doi: 10.1016/j.anndiagpath.2011.08.011. PMID: 22197541
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102
Necrotizing sialometaplasia.
Nilsen R, Bernhoft CH, Gilhuus-Moe O
Int J Oral Surg 1978 Dec;7(6):580-4. doi: 10.1016/s0300-9785(78)80077-5. PMID: 103857

Prognosis

Necrotizing sialometaplasia: a malignant masquerade but questionable precancerous lesion, report of four cases.
Shin SA, Na HY, Choe JY, Hong SN, Lee H, Park S, Kim JE
BMC Oral Health 2020 Jul 14;20(1):206. doi: 10.1186/s12903-020-01189-1. PMID: 32664899Free PMC Article
Necrotizing Sialometaplasia of the Hypopharynx.
Gadkaree SK, Fuller JC, Sadow PM, Deschler DG, Richmon JD
Ear Nose Throat J 2019 Oct-Nov;98(9):NP138-NP141. Epub 2019 Apr 9 doi: 10.1177/0145561319840826. PMID: 30966809Free PMC Article
Review of the literature on necrotizing sialometaplasia and case presentation.
Ledesma-Montes C, Garcés-Ortíz M, Salcido-García JF, Hernández-Flores F
Quintessence Int 2015 Jan;46(1):67-72. doi: 10.3290/j.qi.a32633. PMID: 25191669
Necrotizing sialometaplasia: an unusual bilateral presentation associated with antecedent anaesthesia and lack of response to intralesional steroids. Case report and review of the literature.
Keogh PV, O'Regan E, Toner M, Flint S
Br Dent J 2004 Jan 24;196(2):79-81. doi: 10.1038/sj.bdj.4810892. PMID: 14739958
Necrotizing sialometaplasia.
Penner CR, Thompson LD
Ear Nose Throat J 2003 Jul;82(7):493-4. PMID: 12955830

Clinical prediction guides

Necrotizing sialometaplasia: a case report of a non-ulcerated histopathological presentation.
Néri JDSV, Silva VPD, Ramalho LMP, De Castro LP, Santos JND
Dermatol Online J 2020 Dec 15;26(12) PMID: 33423426
Histological reclassification of parotid gland carcinomas: importance for clinicians.
Stodulski D, Majewska H, Skálová A, Mikaszewski B, Biernat W, Stankiewicz C
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3937-3942. Epub 2016 Apr 21 doi: 10.1007/s00405-016-4048-8. PMID: 27101824Free PMC Article
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia.
Gomez A, Gladstone G
Orbit 2016;35(1):48-50. Epub 2015 Dec 3 doi: 10.3109/01676830.2015.1099687. PMID: 26634609
HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia.
Allon I, Kaplan I, Allon DM, Vered H, Shlomi B, Hirshberg A
Oral Dis 2014 Jul;20(5):440-5. Epub 2013 Jul 10 doi: 10.1111/odi.12149. PMID: 23837804
Subacute necrotizing sialadenitis: a clinicopathological study.
Suresh L, Aguirre A
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Sep;104(3):385-90. Epub 2006 Dec 4 doi: 10.1016/j.tripleo.2006.08.012. PMID: 17142073

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