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Absence seizure

MedGen UID:
4989
Concept ID:
C0014553
Disease or Syndrome
Synonym: Absence epilepsy
SNOMED CT: Generalized non-motor seizure (79631006); Generalized onset non-motor seizure (79631006); Absence seizure (79631006); Generalized-onset non-motor seizure (79631006); GAS - generalized absence seizure (79631006)
 
Related genes: CACNA1H, GABRB3
 
Monarch Initiative: MONDO:0850093

Definition

Absence seizures present with a cessation of activity and impaired awareness associated with generalized spike and wave on EEG (electroencephalogram). An absence seizure is a generalized onset seizure and therefore, it originates at some point within, and rapidly engages, bilaterally distributed networks. [from SNOMEDCT_US]

Professional guidelines

PubMed

Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571
Montouris GD, Wheless JW, Glauser TA
Epilepsia 2014 Sep;55 Suppl 4:10-20. doi: 10.1111/epi.12732. PMID: 25284033
Alexander GM, Godwin DW
Epilepsy Res 2006 Sep;71(1):1-22. Epub 2006 Jun 19 doi: 10.1016/j.eplepsyres.2006.05.012. PMID: 16787741

Recent clinical studies

Etiology

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Bast T, Schulz AL, Floricel F, Morita D, Cleveland JM, Elshoff JP
Epilepsia Open 2022 Dec;7(4):588-597. Epub 2022 Aug 4 doi: 10.1002/epi4.12628. PMID: 35844134Free PMC Article
Bialer M, Perucca E
CNS Drugs 2022 Feb;36(2):113-122. Epub 2022 Jan 30 doi: 10.1007/s40263-022-00896-3. PMID: 35094259
Thieux M, Duca M, Putois B, Herbillon V, Cottone C, Parmeggiani A, Arzimanoglou A, de Bellescize J, Franco P
Epilepsy Behav 2022 Mar;128:108513. Epub 2022 Jan 24 doi: 10.1016/j.yebeh.2021.108513. PMID: 35085916
Alexander GM, Godwin DW
Epilepsy Res 2006 Sep;71(1):1-22. Epub 2006 Jun 19 doi: 10.1016/j.eplepsyres.2006.05.012. PMID: 16787741

Diagnosis

Yan X, Yang D, Lin Z, Vucetic B
IEEE Trans Neural Syst Rehabil Eng 2022;30:668-677. Epub 2022 Mar 22 doi: 10.1109/TNSRE.2022.3156931. PMID: 35245199
Thieux M, Duca M, Putois B, Herbillon V, Cottone C, Parmeggiani A, Arzimanoglou A, de Bellescize J, Franco P
Epilepsy Behav 2022 Mar;128:108513. Epub 2022 Jan 24 doi: 10.1016/j.yebeh.2021.108513. PMID: 35085916
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
van Luijtelaar G, Onat FY, Gallagher MJ
Neurobiol Dis 2014 Dec;72 Pt B:167-79. Epub 2014 Aug 15 doi: 10.1016/j.nbd.2014.08.014. PMID: 25132554Free PMC Article
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Therapy

Bast T, Schulz AL, Floricel F, Morita D, Cleveland JM, Elshoff JP
Epilepsia Open 2022 Dec;7(4):588-597. Epub 2022 Aug 4 doi: 10.1002/epi4.12628. PMID: 35844134Free PMC Article
Bialer M, Perucca E
CNS Drugs 2022 Feb;36(2):113-122. Epub 2022 Jan 30 doi: 10.1007/s40263-022-00896-3. PMID: 35094259
Guilhoto LM
Seizure 2017 Jan;44:53-57. Epub 2016 Dec 6 doi: 10.1016/j.seizure.2016.11.031. PMID: 27986418
Montouris GD, Wheless JW, Glauser TA
Epilepsia 2014 Sep;55 Suppl 4:10-20. doi: 10.1111/epi.12732. PMID: 25284033
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Prognosis

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Thieux M, Duca M, Putois B, Herbillon V, Cottone C, Parmeggiani A, Arzimanoglou A, de Bellescize J, Franco P
Epilepsy Behav 2022 Mar;128:108513. Epub 2022 Jan 24 doi: 10.1016/j.yebeh.2021.108513. PMID: 35085916
Vlachou M, Skrimpas GA, Kural MA, Rackauskaite G, Nikanorova N, Christensen J, Nikanorova M, Beniczky S
Epileptic Disord 2022 Apr 1;24(2):315-322. doi: 10.1684/epd.2021.1392. PMID: 34859792
Guilhoto LM
Seizure 2017 Jan;44:53-57. Epub 2016 Dec 6 doi: 10.1016/j.seizure.2016.11.031. PMID: 27986418
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Clinical prediction guides

Thieux M, Duca M, Putois B, Herbillon V, Cottone C, Parmeggiani A, Arzimanoglou A, de Bellescize J, Franco P
Epilepsy Behav 2022 Mar;128:108513. Epub 2022 Jan 24 doi: 10.1016/j.yebeh.2021.108513. PMID: 35085916
Tenney JR, Williamson BJ, Kadis DS
Brain Connect 2022 Jun;12(5):489-496. Epub 2021 Sep 24 doi: 10.1089/brain.2021.0119. PMID: 34405685
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Guilhoto LM
Seizure 2017 Jan;44:53-57. Epub 2016 Dec 6 doi: 10.1016/j.seizure.2016.11.031. PMID: 27986418
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Recent systematic reviews

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796

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