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Splenic infarction

MedGen UID:
52468
Concept ID:
C0037998
Disease or Syndrome
Synonyms: Infarct of the Spleen; Infarct, Splenic; Infarction, Splenic; Infarctions, Splenic; Infarcts, Splenic; Splenic Infarct; Splenic Infarction; Splenic Infarctions; Splenic Infarcts
SNOMED CT: Infarction of spleen (22996003); Splenic infarction (22996003)
 
HPO: HP:0034336
Monarch Initiative: MONDO:0006978

Definition

Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic infarction

Conditions with this feature

Hb SS disease
MedGen UID:
287
Concept ID:
C0002895
Disease or Syndrome
Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Vaso-occlusive events result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, including the bones, spleen, liver, brain, lungs, kidneys, and joints. Dactylitis (pain and/or swelling of the hands or feet) is often the earliest manifestation of SCD. In children, the spleen can become engorged with blood cells in a "splenic sequestration." The spleen is particularly vulnerable to infarction and the majority of individuals with SCD who are not on hydroxyurea or transfusion therapy become functionally asplenic in early childhood, increasing their risk for certain types of bacterial infections, primarily encapsulated organisms. Acute chest syndrome (ACS) is a major cause of mortality in SCD. Chronic hemolysis can result in varying degrees of anemia, jaundice, cholelithiasis, and delayed growth and sexual maturation as well as activating pathways that contribute to the pathophysiology directly. Individuals with the highest rates of hemolysis are at higher risk for pulmonary artery hypertension, priapism, and leg ulcers and may be relatively protected from vaso-occlusive pain.

Professional guidelines

PubMed

Wang Z, Peng C, Wu D, Wang K, Chen Y
BMC Pediatr 2022 Jul 22;22(1):440. doi: 10.1186/s12887-022-03484-y. PMID: 35864485Free PMC Article
Mousavimaleki A, Amr B, Taherzadeh M, Rokhgireh S, Setaredan SA, Kermansaravi M
Obes Surg 2022 Sep;32(9):3125-3137. Epub 2022 Jul 1 doi: 10.1007/s11695-022-06190-x. PMID: 35778627
Yen CC, Wang CK, Chen SY, Gao SY, Lo HY, Ng CJ, Chaou CH
Sci Rep 2021 Nov 2;11(1):21423. doi: 10.1038/s41598-021-00897-0. PMID: 34728700Free PMC Article

Recent clinical studies

Etiology

Ueda J, Mamada Y, Taniai N, Yoshioka M, Matsushita A, Mizutani S, Kawano Y, Shimizu T, Kanda T, Takata H, Furuki H, Aoki Y, Kawashima M, Irie T, Ohno T, Haruna T, Yoshida H
J Int Med Res 2023 Aug;51(8):3000605231190967. doi: 10.1177/03000605231190967. PMID: 37560966Free PMC Article
Toti JMA, Gatti B, Hunjan I, Kottanattu L, Faré PB, Renzi S, Bianchetti MG, Milani GP, Lava SAG, Camozzi P
Swiss Med Wkly 2023 May 17;153:40081. doi: 10.57187/smw.2023.40081. PMID: 37245117
Im JH, Chung MH, Lee HJ, Kwon HY, Baek JH, Jang JH, Lee JS
BMC Infect Dis 2020 Dec 2;20(1):915. doi: 10.1186/s12879-020-05645-9. PMID: 33267828Free PMC Article
Gercik O, Karasu S, Solmaz D, Soypacaci Z, Cakalagaoglu F, Akar S
Clin Rheumatol 2020 Jun;39(6):1929-1934. Epub 2020 Feb 27 doi: 10.1007/s10067-020-04993-w. PMID: 32107662
Buehner M, Baker MS
Surg Gynecol Obstet 1992 Oct;175(4):373-87. PMID: 1411897

Diagnosis

Mousavimaleki A, Amr B, Taherzadeh M, Rokhgireh S, Setaredan SA, Kermansaravi M
Obes Surg 2022 Sep;32(9):3125-3137. Epub 2022 Jul 1 doi: 10.1007/s11695-022-06190-x. PMID: 35778627
Im JH, Chung MH, Lee HJ, Kwon HY, Baek JH, Jang JH, Lee JS
BMC Infect Dis 2020 Dec 2;20(1):915. doi: 10.1186/s12879-020-05645-9. PMID: 33267828Free PMC Article
Reisner DC, Burgan CM
Curr Probl Diagn Radiol 2018 Jan-Feb;47(1):68-70. Epub 2017 Feb 16 doi: 10.1067/j.cpradiol.2017.02.007. PMID: 28385371
Hwang JH, Lee CS
Am J Trop Med Hyg 2014 Dec;91(6):1094-100. Epub 2014 Oct 6 doi: 10.4269/ajtmh.14-0190. PMID: 25294615Free PMC Article
Norman FF, Rojas-Marcos J, Hermida-Donate JM, Monge-Maillo B, Perez-Molina JA, López-Vélez R
Trans R Soc Trop Med Hyg 2014 Aug;108(8):455-60. Epub 2014 Jun 18 doi: 10.1093/trstmh/tru095. PMID: 24942899

Therapy

Liu XJ, Liu YX, Zhang NY
Medicine (Baltimore) 2023 Jul 28;102(30):e34449. doi: 10.1097/MD.0000000000034449. PMID: 37505132Free PMC Article
Wang Z, Peng C, Wu D, Wang K, Chen Y
BMC Pediatr 2022 Jul 22;22(1):440. doi: 10.1186/s12887-022-03484-y. PMID: 35864485Free PMC Article
Mousavimaleki A, Amr B, Taherzadeh M, Rokhgireh S, Setaredan SA, Kermansaravi M
Obes Surg 2022 Sep;32(9):3125-3137. Epub 2022 Jul 1 doi: 10.1007/s11695-022-06190-x. PMID: 35778627
Lozano Sánchez FS, García-Alonso J, Torres JA, Velasco L, Salvador R, Peña R, González-Porras JR
Int Angiol 2020 Jun;39(3):241-251. Epub 2020 Feb 13 doi: 10.23736/S0392-9590.20.04304-7. PMID: 32057214
Al-Khinji A, Linenberger M
Transfusion 2015 Apr;55(4):708. doi: 10.1111/trf.12851. PMID: 26840787

Prognosis

Zhang D, Lai J, Su G, Zhu J, Min, Kang, Li M, Xu Y, Meng L
Arthritis Res Ther 2024 Jan 17;26(1):28. doi: 10.1186/s13075-024-03265-1. PMID: 38233944Free PMC Article
Lee SB, Kim JH, Park SJ, Park CI, Kim CW
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):297-303. doi: 10.14744/tjtes.2021.62221. PMID: 36880613Free PMC Article
Wang Z, Peng C, Wu D, Wang K, Chen Y
BMC Pediatr 2022 Jul 22;22(1):440. doi: 10.1186/s12887-022-03484-y. PMID: 35864485Free PMC Article
Weber E, Grangeon F, Reynaud Q, Hot A, Sève P, Jardel S, Tazarourte K, Fouque D, Juillard L, Salles G, Grange C, Durieu I, Rousset P, Lega JC
QJM 2020 Mar 1;113(3):186-193. doi: 10.1093/qjmed/hcz252. PMID: 31593227
Norman FF, Rojas-Marcos J, Hermida-Donate JM, Monge-Maillo B, Perez-Molina JA, López-Vélez R
Trans R Soc Trop Med Hyg 2014 Aug;108(8):455-60. Epub 2014 Jun 18 doi: 10.1093/trstmh/tru095. PMID: 24942899

Clinical prediction guides

Zhang D, Lai J, Su G, Zhu J, Min, Kang, Li M, Xu Y, Meng L
Arthritis Res Ther 2024 Jan 17;26(1):28. doi: 10.1186/s13075-024-03265-1. PMID: 38233944Free PMC Article
Toti JMA, Gatti B, Hunjan I, Kottanattu L, Faré PB, Renzi S, Bianchetti MG, Milani GP, Lava SAG, Camozzi P
Swiss Med Wkly 2023 May 17;153:40081. doi: 10.57187/smw.2023.40081. PMID: 37245117
Wang Z, Peng C, Wu D, Wang K, Chen Y
BMC Pediatr 2022 Jul 22;22(1):440. doi: 10.1186/s12887-022-03484-y. PMID: 35864485Free PMC Article
Hwang JH, Lee CS
Am J Trop Med Hyg 2014 Dec;91(6):1094-100. Epub 2014 Oct 6 doi: 10.4269/ajtmh.14-0190. PMID: 25294615Free PMC Article
Norman FF, Rojas-Marcos J, Hermida-Donate JM, Monge-Maillo B, Perez-Molina JA, López-Vélez R
Trans R Soc Trop Med Hyg 2014 Aug;108(8):455-60. Epub 2014 Jun 18 doi: 10.1093/trstmh/tru095. PMID: 24942899

Recent systematic reviews

Toti JMA, Gatti B, Hunjan I, Kottanattu L, Faré PB, Renzi S, Bianchetti MG, Milani GP, Lava SAG, Camozzi P
Swiss Med Wkly 2023 May 17;153:40081. doi: 10.57187/smw.2023.40081. PMID: 37245117
Granieri S, Bonomi A, Frassini S, Gjoni E, Germini A, Kersik A, Bracchetti G, Bruno F, Paleino S, Lomaglio L, Frontali A, Cotsoglou C
HPB (Oxford) 2023 Jun;25(6):614-624. Epub 2023 Mar 1 doi: 10.1016/j.hpb.2023.02.009. PMID: 36941150
Mousavimaleki A, Amr B, Taherzadeh M, Rokhgireh S, Setaredan SA, Kermansaravi M
Obes Surg 2022 Sep;32(9):3125-3137. Epub 2022 Jul 1 doi: 10.1007/s11695-022-06190-x. PMID: 35778627
Hang K, Zhou L, Liu H, Huang Y, Zhang H, Tan C, Xiong J, Li K
Int J Surg 2022 Jul;103:106686. Epub 2022 May 20 doi: 10.1016/j.ijsu.2022.106686. PMID: 35605839
Jain G, Chakravartty S, Patel AG
HPB (Oxford) 2013 Jun;15(6):403-10. Epub 2012 Dec 2 doi: 10.1111/hpb.12003. PMID: 23458666Free PMC Article

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