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Waterhouse-Friderichsen Syndrome

MedGen UID:
53065
Concept ID:
C0043068
Disease or Syndrome
Synonyms: Purpura Fulminans (Waterhouse-Friderichsen Syndrome); Waterhouse Friderichsen Syndrome; Waterhouse Friederichsen Syndrome; Waterhouse-Friederichsen Syndrome

Definition

A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWaterhouse-Friderichsen Syndrome
Follow this link to review classifications for Waterhouse-Friderichsen Syndrome in Orphanet.

Professional guidelines

PubMed

McMILLAN CD, POWELL WN, HAINES RD
Med Clin North Am 1955 Jul;Cleveland No.:1111-25. doi: 10.1016/s0025-7125(16)34745-9. PMID: 14393163
CHOU TC, ANAGNOS SG
Med Ann Dist Columbia 1953 Nov;22(11):604-7. PMID: 13098452
UHL HS
N Engl J Med 1953 Aug 6;249(6):229-32. doi: 10.1056/NEJM195308062490603. PMID: 13072798

Recent clinical studies

Etiology

Okabayashi T, Hanazaki K
World J Gastroenterol 2008 Jan 14;14(2):176-9. doi: 10.3748/wjg.14.176. PMID: 18186551Free PMC Article
Gamper G, Oschatz E, Herkner H, Paul G, Burgmann H, Janata K, Röggla M, Laggner AN
Wien Klin Wochenschr 2001 Feb 15;113(3-4):107-12. PMID: 11253735
Mele JA 3rd, Linder S, Capozzi A
Ann Plast Surg 1997 Mar;38(3):283-90. doi: 10.1097/00000637-199703000-00017. PMID: 9088469
Kumar P, Verma IC
Bull World Health Organ 1993;71(2):183-8. PMID: 8490981Free PMC Article
Marnejon T, Watanakunakorn C
South Med J 1991 Apr;84(4):527-9. doi: 10.1097/00007611-199104000-00034. PMID: 1901668

Diagnosis

Rijal R, Kandel K, Aryal BB, Asija A, Shrestha DB, Sedhai YR
Vitam Horm 2024;124:449-461. Epub 2023 Nov 8 doi: 10.1016/bs.vh.2023.06.001. PMID: 38408808
Hawi N, Liodakis E, Sasse M
Dtsch Arztebl Int 2020 Feb 28;117(9):147. doi: 10.3238/arztebl.2020.0147b. PMID: 32234194Free PMC Article
Miesbach W, Berntorp E
Eur J Haematol 2011 Jun;86(6):496-501. doi: 10.1111/j.1600-0609.2011.01611.x. PMID: 21418329
Holmes FF, Weyandt T, Glazier J, Cuppage FE, Moral LA, Lindsey NJ
JAMA 1981 Sep 4;246(10):1119-20. PMID: 6790733
Zavell PM
Mich Med 1975 Dec;74(36):758. PMID: 1207489

Therapy

Miesbach W, Berntorp E
Eur J Haematol 2011 Jun;86(6):496-501. doi: 10.1111/j.1600-0609.2011.01611.x. PMID: 21418329
Okabayashi T, Hanazaki K
World J Gastroenterol 2008 Jan 14;14(2):176-9. doi: 10.3748/wjg.14.176. PMID: 18186551Free PMC Article
Chang WN, Lu CH, Huang CR, Chuang YC
Infection 2000 Nov-Dec;28(6):395-7. doi: 10.1007/s150100070013. PMID: 11139162
Mele JA 3rd, Linder S, Capozzi A
Ann Plast Surg 1997 Mar;38(3):283-90. doi: 10.1097/00000637-199703000-00017. PMID: 9088469
Kumar P, Verma IC
Bull World Health Organ 1993;71(2):183-8. PMID: 8490981Free PMC Article

Prognosis

Rijal R, Kandel K, Aryal BB, Asija A, Shrestha DB, Sedhai YR
Vitam Horm 2024;124:449-461. Epub 2023 Nov 8 doi: 10.1016/bs.vh.2023.06.001. PMID: 38408808
Hawi N, Liodakis E, Sasse M
Dtsch Arztebl Int 2020 Feb 28;117(9):147. doi: 10.3238/arztebl.2020.0147b. PMID: 32234194Free PMC Article
Okabayashi T, Hanazaki K
World J Gastroenterol 2008 Jan 14;14(2):176-9. doi: 10.3748/wjg.14.176. PMID: 18186551Free PMC Article
Chang WN, Lu CH, Huang CR, Chuang YC
Infection 2000 Nov-Dec;28(6):395-7. doi: 10.1007/s150100070013. PMID: 11139162
Mele JA 3rd, Linder S, Capozzi A
Ann Plast Surg 1997 Mar;38(3):283-90. doi: 10.1097/00000637-199703000-00017. PMID: 9088469

Clinical prediction guides

Velghe D, Apers T, Devriendt S, Deblier I, Hendriks B, Nieuwendijk R, Rogiers P
Crit Care Med 2017 Aug;45(8):e867-e871. doi: 10.1097/CCM.0000000000002438. PMID: 28441232
Okabayashi T, Hanazaki K
World J Gastroenterol 2008 Jan 14;14(2):176-9. doi: 10.3748/wjg.14.176. PMID: 18186551Free PMC Article
Ringe HI, Varnholt V, Gaedicke G
Pediatr Crit Care Med 2003 Oct;4(4):471-5. doi: 10.1097/01.PCC.0000074275.61913.72. PMID: 14525645
Gamper G, Oschatz E, Herkner H, Paul G, Burgmann H, Janata K, Röggla M, Laggner AN
Wien Klin Wochenschr 2001 Feb 15;113(3-4):107-12. PMID: 11253735
Schött U, Björsell-Ostling E
Can J Anaesth 1995 Jan;42(1):64-8. doi: 10.1007/BF03010573. PMID: 7889586

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