U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hand pain

MedGen UID:
536933
Concept ID:
C0239833
Sign or Symptom
Synonym: Painful hand
SNOMED CT: Hand pain (53057004); Painful hand (53057004)
 
HPO: HP:0046505

Definition

An unpleasant sensation characterized by physical discomfort localized to the hand. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHand pain

Conditions with this feature

Mucopolysaccharidosis, MPS-I-H/S
MedGen UID:
88566
Concept ID:
C0086431
Disease or Syndrome
Mucopolysaccharidosis type I (MPS I) is a progressive multisystem disorder with features ranging over a continuum of severity. While affected individuals have traditionally been classified as having one of three MPS I syndromes (Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome), no easily measurable biochemical differences have been identified and the clinical findings overlap. Affected individuals are best described as having either a phenotype consistent with either severe (Hurler syndrome) or attenuated MPS I, a distinction that influences therapeutic options. Severe MPS I. Infants appear normal at birth. Typical early manifestations are nonspecific (e.g., umbilical or inguinal hernia, frequent upper respiratory tract infections before age 1 year). Coarsening of the facial features may not become apparent until after age one year. Gibbus deformity of the lower spine is common and often noted within the first year. Progressive skeletal dysplasia (dysostosis multiplex) involving all bones is universal, as is progressive arthropathy involving most joints. By age three years, linear growth decreases. Intellectual disability is progressive and profound but may not be readily apparent in the first year of life. Progressive cardiorespiratory involvement, hearing loss, and corneal clouding are common. Without treatment, death (typically from cardiorespiratory failure) usually occurs within the first ten years of life. Attenuated MPS I. Clinical onset is usually between ages three and ten years. The severity and rate of disease progression range from serious life-threatening complications leading to death in the second to third decade, to a normal life span complicated by significant disability from progressive joint manifestations and cardiorespiratory disease. While some individuals have no neurologic involvement and psychomotor development may be normal in early childhood, learning disabilities and psychiatric manifestations can be present later in life. Hearing loss, cardiac valvular disease, respiratory involvement, and corneal clouding are common.
Carpal tunnel syndrome 2
MedGen UID:
1725962
Concept ID:
C5436916
Disease or Syndrome
Carpal tunnel syndrome-2 (CTS2) is characterized by the relatively early onset of symptoms of median nerve compression in the wrist. Patients experience pain and numbness in the thumb, index, and middle fingers, correlating with the median nerve distribution in the hand. In addition to thickening of the tendons and ligaments of the wrist, thickening of other tendons has been observed (Li et al., 2020). For a general phenotypic description and discussion of genetic heterogeneity of carpal tunnel syndrome, see CTS1 (115430).

Professional guidelines

PubMed

Malakootian M, Soveizi M, Gholipour A, Oveisee M
Cell Mol Neurobiol 2023 Jul;43(5):1817-1831. Epub 2022 Oct 10 doi: 10.1007/s10571-022-01297-2. PMID: 36217059
Braun C, McRobert CJ
Cochrane Database Syst Rev 2019 May 10;5(5):CD004962. doi: 10.1002/14651858.CD004962.pub4. PMID: 31074847Free PMC Article
Erickson M, Lawrence M, Jansen CWS, Coker D, Amadio P, Cleary C
J Orthop Sports Phys Ther 2019 May;49(5):CPG1-CPG85. doi: 10.2519/jospt.2019.0301. PMID: 31039690

Recent clinical studies

Etiology

Malakootian M, Soveizi M, Gholipour A, Oveisee M
Cell Mol Neurobiol 2023 Jul;43(5):1817-1831. Epub 2022 Oct 10 doi: 10.1007/s10571-022-01297-2. PMID: 36217059
Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A
Medicine (Baltimore) 2020 Mar;99(10):e19124. doi: 10.1097/MD.0000000000019124. PMID: 32150053Free PMC Article
Braun C, McRobert CJ
Cochrane Database Syst Rev 2019 May 10;5(5):CD004962. doi: 10.1002/14651858.CD004962.pub4. PMID: 31074847Free PMC Article
Plessas A, Bernardes Delgado M
Int J Dent Hyg 2018 Nov;16(4):430-440. Epub 2018 Jan 10 doi: 10.1111/idh.12327. PMID: 29318741
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
Cochrane Database Syst Rev 2017 Jan 31;1(1):CD010388. doi: 10.1002/14651858.CD010388.pub2. PMID: 28141914Free PMC Article

Diagnosis

Ferraro E, Ferraro J, Pavlesen S, Carlson C, Ablove T, Ablove R
WMJ 2023 May;122(2):110-113. PMID: 37141474
Malakootian M, Soveizi M, Gholipour A, Oveisee M
Cell Mol Neurobiol 2023 Jul;43(5):1817-1831. Epub 2022 Oct 10 doi: 10.1007/s10571-022-01297-2. PMID: 36217059
Calotta NA, Dellon AL
J Hand Surg Am 2022 Feb;47(2):172-179. Epub 2021 Dec 7 doi: 10.1016/j.jhsa.2021.10.009. PMID: 34887137
Matthews A, Smith K, Read L, Nicholas J, Schmidt E
JAAPA 2019 Jan;32(1):17-21. doi: 10.1097/01.JAA.0000550281.42592.97. PMID: 30589729
Morris G, Evans S, Stevenson J, Kotecha A, Parry M, Jeys L, Grimer R
Ann R Coll Surg Engl 2017 Sep;99(7):563-567. doi: 10.1308/rcsann.2017.0096. PMID: 28853594Free PMC Article

Therapy

Liu X, Robbins S, Eyles J, Fedorova T, Virk S, Deveza LA, McLachlan AJ, Hunter DJ
Osteoarthritis Cartilage 2021 May;29(5):667-677. Epub 2021 Feb 19 doi: 10.1016/j.joca.2021.01.011. PMID: 33617972
Braun C, McRobert CJ
Cochrane Database Syst Rev 2019 May 10;5(5):CD004962. doi: 10.1002/14651858.CD004962.pub4. PMID: 31074847Free PMC Article
Matthews A, Smith K, Read L, Nicholas J, Schmidt E
JAAPA 2019 Jan;32(1):17-21. doi: 10.1097/01.JAA.0000550281.42592.97. PMID: 30589729
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
J Rheumatol 2017 Dec;44(12):1850-1858. Epub 2017 Oct 15 doi: 10.3899/jrheum.170424. PMID: 29032354
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
Cochrane Database Syst Rev 2017 Jan 31;1(1):CD010388. doi: 10.1002/14651858.CD010388.pub2. PMID: 28141914Free PMC Article

Prognosis

Mattap SM, Laslett LL, Squibb K, Wills K, Otahal P, Pan F, Aitken D, Keen H, Cicuttini F, Winzenberg T, Jones G
Arthritis Care Res (Hoboken) 2021 Mar;73(3):347-354. doi: 10.1002/acr.24128. PMID: 31841267
Morris G, Evans S, Stevenson J, Kotecha A, Parry M, Jeys L, Grimer R
Ann R Coll Surg Engl 2017 Sep;99(7):563-567. doi: 10.1308/rcsann.2017.0096. PMID: 28853594Free PMC Article
House R, Krajnak K, Jiang D
Occup Med (Lond) 2016 Jun;66(4):292-5. Epub 2016 Feb 28 doi: 10.1093/occmed/kqw022. PMID: 26928857Free PMC Article
Leon C, Asif A
Clin J Am Soc Nephrol 2007 Jan;2(1):175-83. Epub 2006 Nov 2 doi: 10.2215/CJN.02230606. PMID: 17699402
Treede RD
Ann Med 1995 Apr;27(2):213-6. doi: 10.3109/07853899509031961. PMID: 7632416

Clinical prediction guides

Ferraro E, Ferraro J, Pavlesen S, Carlson C, Ablove T, Ablove R
WMJ 2023 May;122(2):110-113. PMID: 37141474
Rice DA, Lewis GN, Graven-Nielsen T, Luther R, McNair PJ
J Pain 2021 Jul;22(7):789-796. Epub 2021 Feb 3 doi: 10.1016/j.jpain.2021.01.006. PMID: 33548487
Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A
Medicine (Baltimore) 2020 Mar;99(10):e19124. doi: 10.1097/MD.0000000000019124. PMID: 32150053Free PMC Article
Riečanský I, Lamm C
Brain Topogr 2019 Nov;32(6):965-976. Epub 2019 Nov 8 doi: 10.1007/s10548-019-00738-4. PMID: 31705422Free PMC Article
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
Cochrane Database Syst Rev 2017 Jan 31;1(1):CD010388. doi: 10.1002/14651858.CD010388.pub2. PMID: 28141914Free PMC Article

Recent systematic reviews

Nakagawa Y, Tatebe M, Yamamoto M, Kurimoto S, Iwatsuki K, Hirata H
Semin Arthritis Rheum 2021 Aug;51(4):775-785. Epub 2021 Apr 18 doi: 10.1016/j.semarthrit.2021.04.006. PMID: 34146952
Braun C, McRobert CJ
Cochrane Database Syst Rev 2019 May 10;5(5):CD004962. doi: 10.1002/14651858.CD004962.pub4. PMID: 31074847Free PMC Article
Plessas A, Bernardes Delgado M
Int J Dent Hyg 2018 Nov;16(4):430-440. Epub 2018 Jan 10 doi: 10.1111/idh.12327. PMID: 29318741
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
J Rheumatol 2017 Dec;44(12):1850-1858. Epub 2017 Oct 15 doi: 10.3899/jrheum.170424. PMID: 29032354
Østerås N, Kjeken I, Smedslund G, Moe RH, Slatkowsky-Christensen B, Uhlig T, Hagen KB
Cochrane Database Syst Rev 2017 Jan 31;1(1):CD010388. doi: 10.1002/14651858.CD010388.pub2. PMID: 28141914Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...