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Thrombotic stroke

MedGen UID:
537131
•Concept ID:
C0242129
•
Disease or Syndrome
Synonyms: Stroke, Thrombotic; Thrombotic Stroke; Thrombotic Strokes
SNOMED CT: Thrombotic stroke (371040005)

Definition

A type of ischemic stroke resulting from obstruction due to a BLOOD CLOT formed within in a CEREBRAL ARTERY often associated with ATHEROSCLEROSIS. A stroke due to a blood clot in a cerebral vein is a venous infarction (see VENOUS INFARCTION, BRAIN). [from MeSH]

Professional guidelines

PubMed

Neonatal Antiepileptic Medication Treatment Patterns: A Decade of Change.
Le VT, Abdi HH, Sánchez PJ, Yossef L, Reagan PB, Slaughter LA, Firestine A, Slaughter JL
Am J Perinatol 2021 Apr;38(5):469-476. Epub 2019 Oct 10 doi: 10.1055/s-0039-1698457. PMID: 31600794Free PMC Article
The management of stroke in antiphospholipid syndrome.
Panichpisal K, Rozner E, Levine SR
Curr Rheumatol Rep 2012 Feb;14(1):99-106. doi: 10.1007/s11926-011-0223-5. PMID: 22109663
Management of patients with carotid stenosis.
De Fabritiis A, Conti E, Coccheri S
Pathophysiol Haemost Thromb 2002 Sep-Dec;32(5-6):381-5. doi: 10.1159/000073605. PMID: 13679681

Curated

UK NICE Guideline (NG236), Stroke rehabilitation in adults, 2023

UK NICE Guideline NG128, Stroke and transient ischaemic attack in over 16s: diagnosis and initial management, 2019

Recent clinical studies

Etiology

Association Between Ischemic Stroke Subtype and Stroke Severity: The Atherosclerosis Risk in Communities Study.
Johansen MC, Chen J, Schneider ALC, Carlson J, Haight T, Lakshminarayan K, Patole S, Gottesman RF, Coresh J, Koton S
Neurology 2023 Aug 29;101(9):e913-e921. Epub 2023 Jul 6 doi: 10.1212/WNL.0000000000207535. PMID: 37414568Free PMC Article
Neurological Sequelae of COVID-19.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ
J Integr Neurosci 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077. PMID: 35633158
Cardiopulmonary Emergencies in Older Adults.
Theophanous R, Huang W, Ragsdale L
Emerg Med Clin North Am 2021 May;39(2):323-338. doi: 10.1016/j.emc.2021.01.010. PMID: 33863462
Perioperative stroke.
Vlisides P, Mashour GA
Can J Anaesth 2016 Feb;63(2):193-204. Epub 2015 Sep 21 doi: 10.1007/s12630-015-0494-9. PMID: 26391795Free PMC Article
Hypertension and vascular disease.
Doyle AE
Am J Hypertens 1991 Feb;4(2 Pt 2):103S-106S. doi: 10.1093/ajh/4.2.103s. PMID: 2021454

Diagnosis

Previous Ischemic Stroke Significantly Alters Stroke Risk in Newly Diagnosed Cancer Patients.
Lun R, Cerasuolo JO, Carrier M, Gross PL, Kapral MK, Shamy M, Dowlatshahi D, Sutradhar R, Siegal DM
Stroke 2023 Dec;54(12):3064-3073. Epub 2023 Oct 18 doi: 10.1161/STROKEAHA.123.042993. PMID: 37850360
Comparison of Prasugrel and Clopidogrel in Thrombotic Stroke Patients with Risk Factors for Ischemic Stroke Recurrence: An Integrated Analysis of PRASTRO-I, PRASTRO-II, and PRASTRO-III.
Kitazono T, Kamouchi M, Matsumaru Y, Shirai T, Takita A, Kuroda T, Kimura K
Cerebrovasc Dis 2023;52(6):720-729. Epub 2023 Apr 3 doi: 10.1159/000529149. PMID: 37011599
Cardiopulmonary Emergencies in Older Adults.
Theophanous R, Huang W, Ragsdale L
Emerg Med Clin North Am 2021 May;39(2):323-338. doi: 10.1016/j.emc.2021.01.010. PMID: 33863462
Global metabolomics analysis of serum from humans at risk of thrombotic stroke.
Khan A , Shin MS , Jee SH , Park YH
Analyst 2020 Mar 7;145(5):1695-1705. Epub 2020 Jan 2 doi: 10.1039/c9an02032b. PMID: 31895365
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
Pretorius E, Kell DB
Integr Biol (Camb) 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k. PMID: 24714688

Therapy

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
Ischemic Stroke.
Feske SK
Am J Med 2021 Dec;134(12):1457-1464. Epub 2021 Aug 27 doi: 10.1016/j.amjmed.2021.07.027. PMID: 34454905
Cardiopulmonary Emergencies in Older Adults.
Theophanous R, Huang W, Ragsdale L
Emerg Med Clin North Am 2021 May;39(2):323-338. doi: 10.1016/j.emc.2021.01.010. PMID: 33863462
Perioperative stroke.
Vlisides P, Mashour GA
Can J Anaesth 2016 Feb;63(2):193-204. Epub 2015 Sep 21 doi: 10.1007/s12630-015-0494-9. PMID: 26391795Free PMC Article
The management of stroke in antiphospholipid syndrome.
Panichpisal K, Rozner E, Levine SR
Curr Rheumatol Rep 2012 Feb;14(1):99-106. doi: 10.1007/s11926-011-0223-5. PMID: 22109663

Prognosis

Previous Ischemic Stroke Significantly Alters Stroke Risk in Newly Diagnosed Cancer Patients.
Lun R, Cerasuolo JO, Carrier M, Gross PL, Kapral MK, Shamy M, Dowlatshahi D, Sutradhar R, Siegal DM
Stroke 2023 Dec;54(12):3064-3073. Epub 2023 Oct 18 doi: 10.1161/STROKEAHA.123.042993. PMID: 37850360
Global metabolomics analysis of serum from humans at risk of thrombotic stroke.
Khan A , Shin MS , Jee SH , Park YH
Analyst 2020 Mar 7;145(5):1695-1705. Epub 2020 Jan 2 doi: 10.1039/c9an02032b. PMID: 31895365
Stroke and Etonogestrel/Ethinyl Estradiol Ring (NuvaRing): Clinical, Radiological, and Prognostic Features.
Selvan P, Piran P, Balucani C, Tark B, Adler Z, Levine SR
J Stroke Cerebrovasc Dis 2017 Mar;26(3):608-617. Epub 2016 Dec 29 doi: 10.1016/j.jstrokecerebrovasdis.2016.11.111. PMID: 28041897
Thrombotic stroke and myocardial infarction with hormonal contraception.
Lidegaard Ø, Løkkegaard E, Jensen A, Skovlund CW, Keiding N
N Engl J Med 2012 Jun 14;366(24):2257-66. doi: 10.1056/NEJMoa1111840. PMID: 22693997
Lipoprotein (a) and stroke.
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article

Clinical prediction guides

Previous Ischemic Stroke Significantly Alters Stroke Risk in Newly Diagnosed Cancer Patients.
Lun R, Cerasuolo JO, Carrier M, Gross PL, Kapral MK, Shamy M, Dowlatshahi D, Sutradhar R, Siegal DM
Stroke 2023 Dec;54(12):3064-3073. Epub 2023 Oct 18 doi: 10.1161/STROKEAHA.123.042993. PMID: 37850360
Efficacy and Safety of Prasugrel vs Clopidogrel in Thrombotic Stroke Patients With Risk Factors for Ischemic Stroke Recurrence: A Double-blind, Phase III Study (PRASTRO-III).
Kitazono T, Kamouchi M, Matsumaru Y, Nakamura M, Umemura K, Matsuo H, Koyama N, Tsutsumi J, Kimura K
J Atheroscler Thromb 2023 Mar 1;30(3):222-236. Epub 2022 May 21 doi: 10.5551/jat.63473. PMID: 35599000Free PMC Article
Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
The diabetogenic action of statins - mechanisms and clinical implications.
Betteridge DJ, Carmena R
Nat Rev Endocrinol 2016 Feb;12(2):99-110. Epub 2015 Dec 15 doi: 10.1038/nrendo.2015.194. PMID: 26668119
Lipoprotein (a) and stroke.
Milionis HJ, Winder AF, Mikhailidis DP
J Clin Pathol 2000 Jul;53(7):487-96. doi: 10.1136/jcp.53.7.487. PMID: 10961170Free PMC Article

Recent systematic reviews

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, Jadhav AP, Ortega-Gutierrez S, Hill MD, Lima FO, Haussen DC, Brown S, Goyal M, Siddiqui AH, Heit JJ, Menon BK, Kemp S, Budzik R, Urra X, Marks MP, Costalat V, Liebeskind DS, Albers GW
Lancet 2022 Jan 15;399(10321):249-258. Epub 2021 Nov 11 doi: 10.1016/S0140-6736(21)01341-6. PMID: 34774198
Tenecteplase for thrombolysis in stroke patients: Systematic review with meta-analysis.
Oliveira M, Fidalgo M, Fontão L, Antão J, Marques S, Afreixo V, Gregório T
Am J Emerg Med 2021 Apr;42:31-37. Epub 2020 Dec 24 doi: 10.1016/j.ajem.2020.12.026. PMID: 33440328
Atrial fibrillation as a prognostic indicator of myocardial infarction and cardiovascular death: a systematic review and meta-analysis.
He W, Chu Y
Sci Rep 2017 Jun 13;7(1):3360. doi: 10.1038/s41598-017-03653-5. PMID: 28611377Free PMC Article

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    Clinical resources

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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline (NG236), Stroke rehabilitation in adults, 2023
    • NICE, 2019
      UK NICE Guideline NG128, Stroke and transient ischaemic attack in over 16s: diagnosis and initial management, 2019

    Consumer resources

    Reviews

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