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Genital Leukoplakia

MedGen UID:
56242
•Concept ID:
C0151759
•
Disease or Syndrome
Synonyms: Leukoplakia of Genitals; Leukoplakia of the Genitals

Definition

A clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004 [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenital Leukoplakia

Professional guidelines

PubMed

Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Cancers, precancers, and pseudocancers on the male genitalia. A review of clinical appearances, histopathology, and management.
Mikhail GR
J Dermatol Surg Oncol 1980 Dec;6(12):1027-35. doi: 10.1111/j.1524-4725.1980.tb01026.x. PMID: 6259230
"WHITE" VULVAL LESIONS: DIFFERENTIAL DIAGNOSIS AND TREATMENT.
HYMAN AB, FALK HC
Postgrad Med 1963 Dec;34:567-71. doi: 10.1080/00325481.1963.11694942. PMID: 14105626

Recent clinical studies

Etiology

Human papillomavirus and oral disease - emerging evidence: a review.
Prabhu SR, Wilson DF
Aust Dent J 2013 Mar;58(1):2-10; quiz 125. Epub 2013 Jan 31 doi: 10.1111/adj.12020. PMID: 23441786
Dermatologic findings in HIV-1-infected patients: a prospective study with emphasis on CD4+ cell count.
Reynaud-Mendel B, Janier M, Gerbaka J, Hakim C, Rabian C, Chastang C, Morel P
Dermatology 1996;192(4):325-8. doi: 10.1159/000246404. PMID: 8864366
Skin cancer and warts in immunosuppressed renal transplant recipients.
Leigh IM, Glover MT
Recent Results Cancer Res 1995;139:69-86. doi: 10.1007/978-3-642-78771-3_6. PMID: 7597313
The vulvar dystrophies.
Kaufman RH
Obstet Gynecol Annu 1976;5:345-66. PMID: 980276
Leukoplakia of the bladder in females.
Javadpour N, Hakim AA, Bush IM
Obstet Gynecol 1970 Apr;35(4):519-23. PMID: 5461929

Diagnosis

Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Epstein-Barr virus: dermatologic associations and implications: part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders.
Hall LD, Eminger LA, Hesterman KS, Heymann WR
J Am Acad Dermatol 2015 Jan;72(1):1-19; quiz 19-20. doi: 10.1016/j.jaad.2014.07.034. PMID: 25497917
Pachyonychia congenita tarda.
Hannaford RS, Stapleton K
Australas J Dermatol 2000 Aug;41(3):175-7. doi: 10.1046/j.1440-0960.2000.00425.x. PMID: 10954990
Cancers, precancers, and pseudocancers on the male genitalia. A review of clinical appearances, histopathology, and management.
Mikhail GR
J Dermatol Surg Oncol 1980 Dec;6(12):1027-35. doi: 10.1111/j.1524-4725.1980.tb01026.x. PMID: 6259230
Carcinoma of the vulva.
Charles AH
Br Med J 1972 Feb 12;1(5797):397-402. doi: 10.1136/bmj.1.5797.397. PMID: 4550741Free PMC Article

Therapy

Pachyonychia congenita tarda.
Hannaford RS, Stapleton K
Australas J Dermatol 2000 Aug;41(3):175-7. doi: 10.1046/j.1440-0960.2000.00425.x. PMID: 10954990
Skin cancer and warts in immunosuppressed renal transplant recipients.
Leigh IM, Glover MT
Recent Results Cancer Res 1995;139:69-86. doi: 10.1007/978-3-642-78771-3_6. PMID: 7597313
Vulvar dystrophies.
Kaufman RH, Gardner HL
Clin Obstet Gynecol 1978 Dec;21(4):1081-106. doi: 10.1097/00003081-197821040-00013. PMID: 737921
The vulvar dystrophies.
Kaufman RH
Obstet Gynecol Annu 1976;5:345-66. PMID: 980276
Topical androgenic hormones in vulvar kraurosis-leukoplakia syndrome; preliminary report.
RICHARDSON AC, WILLIAMS GA
Am J Obstet Gynecol 1958 Oct;76(4):791-7; discussion 797-9. doi: 10.1016/0002-9378(58)90012-7. PMID: 13583020

Prognosis

Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Dermatologic findings in HIV-1-infected patients: a prospective study with emphasis on CD4+ cell count.
Reynaud-Mendel B, Janier M, Gerbaka J, Hakim C, Rabian C, Chastang C, Morel P
Dermatology 1996;192(4):325-8. doi: 10.1159/000246404. PMID: 8864366
Skin cancer and warts in immunosuppressed renal transplant recipients.
Leigh IM, Glover MT
Recent Results Cancer Res 1995;139:69-86. doi: 10.1007/978-3-642-78771-3_6. PMID: 7597313
The vulvar dystrophies.
Kaufman RH
Obstet Gynecol Annu 1976;5:345-66. PMID: 980276
Leukoplakia of the bladder in females.
Javadpour N, Hakim AA, Bush IM
Obstet Gynecol 1970 Apr;35(4):519-23. PMID: 5461929

Clinical prediction guides

Epstein-Barr virus and skin manifestations in childhood.
Di Lernia V, Mansouri Y
Int J Dermatol 2013 Oct;52(10):1177-84. doi: 10.1111/j.1365-4632.2012.05855.x. PMID: 24073903
Dermatologic manifestations among human immunodeficiency virus patients in south India.
Kumarasamy N, Solomon S, Madhivanan P, Ravikumar B, Thyagarajan SP, Yesudian P
Int J Dermatol 2000 Mar;39(3):192-5. doi: 10.1046/j.1365-4362.2000.00945.x. PMID: 10759958
Leukoplakia of the prepuce with epidermolytic hyperkeratosis: a case report.
Kolde G, Vakilzadeh F
Acta Derm Venereol 1983;63(6):571-3. PMID: 6198860
Dysplasia and cancer in situ of young patients: colposcopic and cytological observations.
Bauer H
J Reprod Med 1974 May;12(5):205-6. PMID: 4838314
A comparison between negative, slightly atypical and suspicious cervical smears and colposcopic observations.
Odell LD, Merrick FW, Ortiz R
Acta Cytol 1968 Jul-Aug;12(4):305-8. PMID: 5243450

Recent systematic reviews

Urologic complications of genitourinary schistosomiasis.
Khalaf I, Shokeir A, Shalaby M
World J Urol 2012 Feb;30(1):31-8. Epub 2011 Sep 10 doi: 10.1007/s00345-011-0751-7. PMID: 21909645

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