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Genital Leukoplakia

MedGen UID:
56242
•Concept ID:
C0151759
•
Disease or Syndrome
Synonyms: Leukoplakia of Genitals; Leukoplakia of the Genitals

Definition

A clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004 [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenital Leukoplakia

Professional guidelines

PubMed

Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Cancers, precancers, and pseudocancers on the male genitalia. A review of clinical appearances, histopathology, and management.
Mikhail GR
J Dermatol Surg Oncol 1980 Dec;6(12):1027-35. doi: 10.1111/j.1524-4725.1980.tb01026.x. PMID: 6259230
"WHITE" VULVAL LESIONS: DIFFERENTIAL DIAGNOSIS AND TREATMENT.
HYMAN AB, FALK HC
Postgrad Med 1963 Dec;34:567-71. doi: 10.1080/00325481.1963.11694942. PMID: 14105626

Recent clinical studies

Etiology

High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs.
Portugal MEG, Raboni SM, Nogueira MB, Vidal LRR, Dingueleski AH, Kluk E, Bonfim C, Ribeiro LL, Torres-Pereira CC
Transpl Infect Dis 2019 Apr;21(2):e13030. Epub 2018 Dec 14 doi: 10.1111/tid.13030. PMID: 30449057
Epstein-Barr virus and skin manifestations in childhood.
Di Lernia V, Mansouri Y
Int J Dermatol 2013 Oct;52(10):1177-84. doi: 10.1111/j.1365-4632.2012.05855.x. PMID: 24073903
Human papillomavirus and oral disease - emerging evidence: a review.
Prabhu SR, Wilson DF
Aust Dent J 2013 Mar;58(1):2-10; quiz 125. Epub 2013 Jan 31 doi: 10.1111/adj.12020. PMID: 23441786
Cutaneous findings associated with HIV disease including AIDS: experience from Sub Saharan Africa.
Pallangyo KJ
Trop Doct 1992;22 Suppl 1:35-41;60. doi: 10.1177/00494755920220S107. PMID: 1492376
A clinico-pathological study of vulval dermatoses.
Leighton PC, Langley FA
J Clin Pathol 1975 May;28(5):394-402. doi: 10.1136/jcp.28.5.394. PMID: 1150891Free PMC Article

Diagnosis

Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.
Tummala H, Walne A, Buccafusca R, Alnajar J, Szabo A, Robinson P, McConkie-Rosell A, Wilson M, Crowley S, Kinsler V, Ewins AM, Madapura PM, Patel M, Pontikos N, Codd V, Vulliamy T, Dokal I
Am J Hum Genet 2022 Aug 4;109(8):1472-1483. doi: 10.1016/j.ajhg.2022.06.014. PMID: 35931051Free PMC Article
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Epstein-Barr virus and skin manifestations in childhood.
Di Lernia V, Mansouri Y
Int J Dermatol 2013 Oct;52(10):1177-84. doi: 10.1111/j.1365-4632.2012.05855.x. PMID: 24073903
Pachyonychia congenita tarda.
Hannaford RS, Stapleton K
Australas J Dermatol 2000 Aug;41(3):175-7. doi: 10.1046/j.1440-0960.2000.00425.x. PMID: 10954990
Carcinoma of the vulva.
Charles AH
Br Med J 1972 Feb 12;1(5797):397-402. doi: 10.1136/bmj.1.5797.397. PMID: 4550741Free PMC Article

Therapy

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China.
Li YY, Yang SH, Wang RR, Tang JT, Wang HM, Kuang YQ
Int J Dermatol 2020 Mar;59(3):308-313. Epub 2019 Dec 17 doi: 10.1111/ijd.14725. PMID: 31846069
High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs.
Portugal MEG, Raboni SM, Nogueira MB, Vidal LRR, Dingueleski AH, Kluk E, Bonfim C, Ribeiro LL, Torres-Pereira CC
Transpl Infect Dis 2019 Apr;21(2):e13030. Epub 2018 Dec 14 doi: 10.1111/tid.13030. PMID: 30449057
Pachyonychia congenita tarda.
Hannaford RS, Stapleton K
Australas J Dermatol 2000 Aug;41(3):175-7. doi: 10.1046/j.1440-0960.2000.00425.x. PMID: 10954990
Immunomodulatory therapy in the management of viral infections in patients with HIV infection.
Conant MA
J Am Acad Dermatol 2000 Jul;43(1 Pt 2):S27-30. doi: 10.1067/mjd.2000.107810. PMID: 10861104
Vulvar dystrophies.
Kaufman RH, Gardner HL
Clin Obstet Gynecol 1978 Dec;21(4):1081-106. doi: 10.1097/00003081-197821040-00013. PMID: 737921

Prognosis

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China.
Li YY, Yang SH, Wang RR, Tang JT, Wang HM, Kuang YQ
Int J Dermatol 2020 Mar;59(3):308-313. Epub 2019 Dec 17 doi: 10.1111/ijd.14725. PMID: 31846069
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Epstein-Barr virus and skin manifestations in childhood.
Di Lernia V, Mansouri Y
Int J Dermatol 2013 Oct;52(10):1177-84. doi: 10.1111/j.1365-4632.2012.05855.x. PMID: 24073903
Single-stage dorsal inlay split-skin graft for salvage anterior urethral reconstruction.
Dalpiaz O, Kerschbaumer A, Pelzer A, Radmayr C, Gozzi C, Horninger W, Bartsch G, Schwentner C
BJU Int 2008 Jun;101(12):1565-70. Epub 2008 Jan 10 doi: 10.1111/j.1464-410X.2007.07436.x. PMID: 18190621
Genital viral infections. Studies on human papillomavirus and Epstein-Barr virus.
Voog E
Acta Derm Venereol Suppl (Stockh) 1996;198:1-55. PMID: 9111847

Clinical prediction guides

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China.
Li YY, Yang SH, Wang RR, Tang JT, Wang HM, Kuang YQ
Int J Dermatol 2020 Mar;59(3):308-313. Epub 2019 Dec 17 doi: 10.1111/ijd.14725. PMID: 31846069
Epstein-Barr virus and skin manifestations in childhood.
Di Lernia V, Mansouri Y
Int J Dermatol 2013 Oct;52(10):1177-84. doi: 10.1111/j.1365-4632.2012.05855.x. PMID: 24073903
Simple clinical manifestations of genital Schistosoma haematobium infection in rural Zimbabwean women.
Kjetland EF, Ndhlovu PD, Mduluza T, Gomo E, Gwanzura L, Mason PR, Kurewa EN, Midzi N, Friis H, Gundersen SG
Am J Trop Med Hyg 2005 Mar;72(3):311-9. PMID: 15772328
Dermatologic manifestations among human immunodeficiency virus patients in south India.
Kumarasamy N, Solomon S, Madhivanan P, Ravikumar B, Thyagarajan SP, Yesudian P
Int J Dermatol 2000 Mar;39(3):192-5. doi: 10.1046/j.1365-4362.2000.00945.x. PMID: 10759958
Cutaneous findings associated with HIV disease including AIDS: experience from Sub Saharan Africa.
Pallangyo KJ
Trop Doct 1992;22 Suppl 1:35-41;60. doi: 10.1177/00494755920220S107. PMID: 1492376

Recent systematic reviews

Urologic complications of genitourinary schistosomiasis.
Khalaf I, Shokeir A, Shalaby M
World J Urol 2012 Feb;30(1):31-8. Epub 2011 Sep 10 doi: 10.1007/s00345-011-0751-7. PMID: 21909645

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