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Spastic hemiparesis

MedGen UID:
56345
•Concept ID:
C0154694
•
Disease or Syndrome; Finding
Synonym: Spastic hemiplegia
SNOMED CT: Spastic hemiplegia (79633009)
 
HPO: HP:0011099
Monarch Initiative: MONDO:0001168

Definition

Unilateral paresis (weakness) with spasticity of the affected muscles and increased tendon reflexes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Spastic hemiparesis

Conditions with this feature

Neurodevelopmental disorder with hearing loss and spasticity
MedGen UID:
1794234
•Concept ID:
C5562024
•
Disease or Syndrome
Neurodevelopmental disorder with hearing loss and spasticity (NEDHLS) is characterized by hearing loss, global developmental delay/impaired intellectual development, spastic-dystonic cerebral palsy, focal or generalized epilepsy, and microcephaly. Some children present with hypotonia (Richard et al., 2021).
See: Condition Record
Neurodevelopmental disorder with hearing loss and spasticity

Professional guidelines

PubMed

Treatment Outcomes of Pediatric Status Epilepticus in a Tertiary Pediatric Intensive Care Unit.
Cavusoglu D, Sınmaz EE, Dundar NO, Can FK, Anil AB, Sarioglu B
Pediatr Emerg Care 2021 Jul 1;37(7):360-364. doi: 10.1097/PEC.0000000000001914. PMID: 32149989
Surgical and molecular considerations in the treatment of pediatric thalamopeduncular tumors.
Lee RP, Foster KA, Lillard JC, Klimo P Jr, Ellison DW, Orr B, Boop FA
J Neurosurg Pediatr 2017 Sep;20(3):247-255. Epub 2017 Jul 7 doi: 10.3171/2017.4.PEDS16668. PMID: 28686121Free PMC Article
Treatment of various movement disorders with botulinum A toxin injection: an experience of 900 patients.
Poungvarin N, Devahastin V, Viriyavejakul A
J Med Assoc Thai 1995 Jun;78(6):281-8. PMID: 7561552

Recent clinical studies

Etiology

Kinect v2-Assisted Semi-Automated Method to Assess Upper Limb Motor Performance in Children.
Francisco-Martínez C, Padilla-Medina JA, Prado-Olivarez J, Pérez-Pinal FJ, Barranco-Gutiérrez AI, Martínez-Nolasco JJ
Sensors (Basel) 2022 Mar 15;22(6) doi: 10.3390/s22062258. PMID: 35336429Free PMC Article
Effects of dual task on gait velocity and cadence in cerebral palsied children with spastic hemiparesis or diparesis.
Kocak A, Yarar F, Cavlak U
Acta Neurol Belg 2021 Feb;121(1):175-179. Epub 2020 May 24 doi: 10.1007/s13760-020-01380-9. PMID: 32449134
Analysis of the effects of low-level laser therapy on muscle fatigue of the biceps brachii muscle of healthy individuals and spastic individuals: Study protocol for a single-center, randomized, double-blind, and controlled clinical trial.
da Silva BP, Souza GADS, Filho AADN, Pinto AP, Guimarães CL, Pereira APC, Neves MFD, Martins PSLL, Lima FPS, Lopes-Martins RAB, Lima MO
Medicine (Baltimore) 2019 Sep;98(39):e17166. doi: 10.1097/MD.0000000000017166. PMID: 31574822Free PMC Article
Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension.
Gracies JM, Esquenazi A, Brashear A, Banach M, Kocer S, Jech R, Khatkova S, Benetin J, Vecchio M, McAllister P, Ilkowski J, Ochudlo S, Catus F, Grandoulier AS, Vilain C, Picaut P; International AbobotulinumtoxinA Adult Lower Limb Spasticity Study Group
Neurology 2017 Nov 28;89(22):2245-2253. Epub 2017 Nov 1 doi: 10.1212/WNL.0000000000004687. PMID: 29093068Free PMC Article
Surgical and molecular considerations in the treatment of pediatric thalamopeduncular tumors.
Lee RP, Foster KA, Lillard JC, Klimo P Jr, Ellison DW, Orr B, Boop FA
J Neurosurg Pediatr 2017 Sep;20(3):247-255. Epub 2017 Jul 7 doi: 10.3171/2017.4.PEDS16668. PMID: 28686121Free PMC Article

Diagnosis

Kinect v2-Assisted Semi-Automated Method to Assess Upper Limb Motor Performance in Children.
Francisco-Martínez C, Padilla-Medina JA, Prado-Olivarez J, Pérez-Pinal FJ, Barranco-Gutiérrez AI, Martínez-Nolasco JJ
Sensors (Basel) 2022 Mar 15;22(6) doi: 10.3390/s22062258. PMID: 35336429Free PMC Article
Effects of dual task on gait velocity and cadence in cerebral palsied children with spastic hemiparesis or diparesis.
Kocak A, Yarar F, Cavlak U
Acta Neurol Belg 2021 Feb;121(1):175-179. Epub 2020 May 24 doi: 10.1007/s13760-020-01380-9. PMID: 32449134
Spasticity-induced Pectoralis minor syndrome: a case-report.
Aktas I, Kaya E, Akpinar P, Atici A, Unlu Ozkan F, Palamar D, Akgun K
Top Stroke Rehabil 2020 May;27(4):316-319. Epub 2019 Nov 27 doi: 10.1080/10749357.2019.1691807. PMID: 31774031
Mills' syndrome revisited.
Jaiser SR, Mitra D, Williams TL, Baker MR
J Neurol 2019 Mar;266(3):667-679. Epub 2019 Jan 10 doi: 10.1007/s00415-019-09186-3. PMID: 30631918Free PMC Article
Manual dexterity and keyboard use in spastic hemiparesis: a comparison between the impaired hand and the 'good' hand on a number of performance measures.
Steenbergen B, Veringa A, de Haan A, Hulstijn W
Clin Rehabil 1998 Feb;12(1):64-72. doi: 10.1177/026921559801200109. PMID: 9549027

Therapy

Capacity for Hand-as-a-Holder Function of the Spastic Combination Hand: A Proof-of-Concept Study.
Mayer NH, Ferraro M, Pauloski-Hunt D, Chervoneva I
Am J Phys Med Rehabil 2022 Mar 1;101(3):298-302. doi: 10.1097/PHM.0000000000001834. PMID: 34173778
Effectiveness of matrix-rhythm therapy on increased muscle tone, balance and gait parameters in stroke survivors: a single-blinded, randomized, controlled clinical trial.
Unal A, Altug F, Tikac G, Cavlak U
Acta Neurol Belg 2021 Jun;121(3):689-699. Epub 2020 Jun 14 doi: 10.1007/s13760-020-01391-6. PMID: 32537732
Efficacy and Safety of AbobotulinumtoxinA for the Treatment of Hemiparesis in Adults with Lower Limb Spasticity Previously Treated With Other Botulinum Toxins: A Secondary Analysis of a Randomized Controlled Trial.
Esquenazi A, Stoquart G, Hedera P, Jacinto LJ, Dimanico U, Constant-Boyer F, Brashear A, Grandoulier AS, Vilain C, Picaut P, Gracies JM
PM R 2020 Sep;12(9):853-860. Epub 2020 Mar 27 doi: 10.1002/pmrj.12348. PMID: 32108436Free PMC Article
Analysis of the effects of low-level laser therapy on muscle fatigue of the biceps brachii muscle of healthy individuals and spastic individuals: Study protocol for a single-center, randomized, double-blind, and controlled clinical trial.
da Silva BP, Souza GADS, Filho AADN, Pinto AP, Guimarães CL, Pereira APC, Neves MFD, Martins PSLL, Lima FPS, Lopes-Martins RAB, Lima MO
Medicine (Baltimore) 2019 Sep;98(39):e17166. doi: 10.1097/MD.0000000000017166. PMID: 31574822Free PMC Article
Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension.
Gracies JM, Esquenazi A, Brashear A, Banach M, Kocer S, Jech R, Khatkova S, Benetin J, Vecchio M, McAllister P, Ilkowski J, Ochudlo S, Catus F, Grandoulier AS, Vilain C, Picaut P; International AbobotulinumtoxinA Adult Lower Limb Spasticity Study Group
Neurology 2017 Nov 28;89(22):2245-2253. Epub 2017 Nov 1 doi: 10.1212/WNL.0000000000004687. PMID: 29093068Free PMC Article

Prognosis

Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension.
Gracies JM, Esquenazi A, Brashear A, Banach M, Kocer S, Jech R, Khatkova S, Benetin J, Vecchio M, McAllister P, Ilkowski J, Ochudlo S, Catus F, Grandoulier AS, Vilain C, Picaut P; International AbobotulinumtoxinA Adult Lower Limb Spasticity Study Group
Neurology 2017 Nov 28;89(22):2245-2253. Epub 2017 Nov 1 doi: 10.1212/WNL.0000000000004687. PMID: 29093068Free PMC Article
Surgical and molecular considerations in the treatment of pediatric thalamopeduncular tumors.
Lee RP, Foster KA, Lillard JC, Klimo P Jr, Ellison DW, Orr B, Boop FA
J Neurosurg Pediatr 2017 Sep;20(3):247-255. Epub 2017 Jul 7 doi: 10.3171/2017.4.PEDS16668. PMID: 28686121Free PMC Article
Selective dorsal rhizotomy in children with spastic hemiparesis.
Oki A, Oberg W, Siebert B, Plante D, Walker ML, Gooch JL
J Neurosurg Pediatr 2010 Oct;6(4):353-8. doi: 10.3171/2010.7.PEDS09318. PMID: 20887108
Botulinum toxin dilution and endplate targeting in spasticity: a double-blind controlled study.
Gracies JM, Lugassy M, Weisz DJ, Vecchio M, Flanagan S, Simpson DM
Arch Phys Med Rehabil 2009 Jan;90(1):9-16.e2. doi: 10.1016/j.apmr.2008.04.030. PMID: 19154823
Outcome, cost analysis, and long-term follow-up in preterm infants with massive grade IV germinal matrix hemorrhage and progressive hydrocephalus.
Pikus HJ, Levy ML, Gans W, Mendel E, McComb JG
Neurosurgery 1997 May;40(5):983-8; discussion 988-9. doi: 10.1097/00006123-199705000-00021. PMID: 9149257

Clinical prediction guides

A Pilot Study of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Subtype A2 for Post-Stroke Lower Limb Spasticity: Comparison with OnabotulinumtoxinA.
Kaji R, Miyashiro A, Sato N, Furumoto T, Takeuchi T, Miyamoto R, Kohda T, Izumi Y, Kozaki S
Toxins (Basel) 2022 Oct 28;14(11) doi: 10.3390/toxins14110739. PMID: 36355989Free PMC Article
Kinect v2-Assisted Semi-Automated Method to Assess Upper Limb Motor Performance in Children.
Francisco-Martínez C, Padilla-Medina JA, Prado-Olivarez J, Pérez-Pinal FJ, Barranco-Gutiérrez AI, Martínez-Nolasco JJ
Sensors (Basel) 2022 Mar 15;22(6) doi: 10.3390/s22062258. PMID: 35336429Free PMC Article
Efficacy and Safety of AbobotulinumtoxinA for the Treatment of Hemiparesis in Adults with Lower Limb Spasticity Previously Treated With Other Botulinum Toxins: A Secondary Analysis of a Randomized Controlled Trial.
Esquenazi A, Stoquart G, Hedera P, Jacinto LJ, Dimanico U, Constant-Boyer F, Brashear A, Grandoulier AS, Vilain C, Picaut P, Gracies JM
PM R 2020 Sep;12(9):853-860. Epub 2020 Mar 27 doi: 10.1002/pmrj.12348. PMID: 32108436Free PMC Article
Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension.
Gracies JM, Esquenazi A, Brashear A, Banach M, Kocer S, Jech R, Khatkova S, Benetin J, Vecchio M, McAllister P, Ilkowski J, Ochudlo S, Catus F, Grandoulier AS, Vilain C, Picaut P; International AbobotulinumtoxinA Adult Lower Limb Spasticity Study Group
Neurology 2017 Nov 28;89(22):2245-2253. Epub 2017 Nov 1 doi: 10.1212/WNL.0000000000004687. PMID: 29093068Free PMC Article
Clinical and radiologic features of unilateral and bilateral schizencephaly in polish pediatric patients.
Kopyta I, Jamroz E, Kluczewska E, Sarecka-Hujar B
J Child Neurol 2014 Apr;29(4):442-9. Epub 2013 Mar 14 doi: 10.1177/0883073813478660. PMID: 23503883

Recent systematic reviews

Muscle and tendon properties of the spastic lower leg after stroke defined by ultrasonography: a systematic review.
Schillebeeckx F, DE Groef A, DE Beukelaer N, Desloovere K, Verheyden G, Peers K
Eur J Phys Rehabil Med 2021 Aug;57(4):495-510. Epub 2020 Dec 11 doi: 10.23736/S1973-9087.20.06462-X. PMID: 33305547

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