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Non-Ossifying Fibroma

MedGen UID:
569529
•Concept ID:
C0334067
•
Neoplastic Process
Synonyms: Fibrous cortical defect; Fibrous cortical defect of bone; Metaphyseal fibrous defect; Non-ossifying fibroma; Nonossified fibroma of bone
SNOMED CT: Metaphyseal fibrous defect (80415005); Non-ossifying fibroma (80415005); Fibrous cortical defect of bone (80415005); Fibrous cortical defect (203470009); Nonossified fibroma of bone (203470009); Non-ossifying fibroma (203470009)

Definition

A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Ossifying Fibroma

Professional guidelines

PubMed

Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.
Andreacchio A, Alberghina F, Testa G, Canavese F
Eur J Orthop Surg Traumatol 2018 Feb;28(2):291-297. Epub 2017 Aug 17 doi: 10.1007/s00590-017-2028-3. PMID: 28819829
Indication and procedure of the operative treatment of benign bone cysts in children and adolescents.
Baschang A, von Laer L
Eur J Pediatr Surg 1991 Aug;1(4):207-9. doi: 10.1055/s-2008-1042489. PMID: 1931839

Recent clinical studies

Etiology

Non-ossifying fibromas and fibrous cortical defects around the knee - an epidemiologic survey in a Japanese pediatric population.
Emori M, Tsuchie H, Teramoto A, Shimizu J, Mizushima E, Murahashi Y, Nagasawa H, Miyakoshi N, Yamashita T
BMC Musculoskelet Disord 2022 Apr 22;23(1):378. doi: 10.1186/s12891-022-05330-9. PMID: 35459158Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Comparison of characteristic features and local recurrence in syndromic versus non-syndromic multifocal non-ossifying fibroma.
Jamshidi K, Motaghi P, Bagherifard A, Eigi M, Al-Baseesee HH, Mirzaei A
J Orthop Sci 2021 Jul;26(4):655-659. Epub 2020 Aug 17 doi: 10.1016/j.jos.2020.06.010. PMID: 32819790
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article
Tumor treated by endoscopy.
Choi Y, Kwak JM, Chung SH, Jung GH, Kim JD
Clin Orthop Surg 2014 Mar;6(1):72-9. Epub 2014 Feb 14 doi: 10.4055/cios.2014.6.1.72. PMID: 24605192Free PMC Article

Diagnosis

Co-Existence of Non-ossifying Fibroma and Osteoblastoma of the Tibia.
Alkan A, Ustabaşıoğlu FE, Usta U, Çiftdemir M, Üstün F
Balkan Med J 2023 Jan 23;40(1):66-67. Epub 2022 Dec 9 doi: 10.4274/balkanmedj.galenos.2022.2022-10-34. PMID: 36482109Free PMC Article
Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
The non-ossifying fibroma: a case report and review of the literature.
Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC Jr, Stavropoulos MF
Head Neck Pathol 2013 Jun;7(2):203-10. Epub 2012 Sep 25 doi: 10.1007/s12105-012-0399-7. PMID: 23008139Free PMC Article
Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review.
Mankin HJ, Trahan CA, Fondren G, Mankin CJ
Chir Organi Mov 2009 May;93(1):1-7. Epub 2009 Apr 29 doi: 10.1007/s12306-009-0016-4. PMID: 19711155

Therapy

Spectrum of histological features of Denosumab treated Giant Cell Tumor of Bone; potential pitfalls and diagnostic challenges for pathologists.
Tariq MU, Umer M, Khan Z, Saeed J, Siddiqui MA, Din NU
Ann Diagn Pathol 2020 Apr;45:151479. Epub 2020 Feb 14 doi: 10.1016/j.anndiagpath.2020.151479. PMID: 32088577
Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.
Andreacchio A, Alberghina F, Testa G, Canavese F
Eur J Orthop Surg Traumatol 2018 Feb;28(2):291-297. Epub 2017 Aug 17 doi: 10.1007/s00590-017-2028-3. PMID: 28819829
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases.
Ceroni D, Dayer R, De Coulon G, Kaelin A
Musculoskelet Surg 2011 Aug;95(2):107-14. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0115-x. PMID: 21409501
Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report.
Sanatkumar S, Rajagopalan N, Mallikarjunaswamy B, Srinivasalu S, Sudhir NP, Usha K
J Orthop Surg (Hong Kong) 2005 Apr;13(1):83-7. doi: 10.1177/230949900501300116. PMID: 15872408

Prognosis

Giant cell tumor of bone in an eighteenth-century Italian mummy.
Ventura L, Petrella E, Piciucchi S, Cilli E, Luiselli D, Feeney RNM, Traversari M
Virchows Arch 2021 Dec;479(6):1255-1261. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03192-5. PMID: 34462806Free PMC Article
Pathological fracture in paediatric bone tumours and tumour-like lesions: A predictor of benign lesions?
Chaib B, Malhotra K, Khoo M, Saifuddin A
Br J Radiol 2021 Sep 1;94(1125):20201341. Epub 2021 Jul 28 doi: 10.1259/bjr.20201341. PMID: 34319796Free PMC Article
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article
Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.
Płaszczyca A, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Domanski HA, Lilljebjörn H, Fioretos T, Tayebwa J, Mandahl N, Nord KH, Mertens F
Int J Biochem Cell Biol 2014 Aug;53:475-81. Epub 2014 Apr 8 doi: 10.1016/j.biocel.2014.03.027. PMID: 24721208
Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible.
Chrcanovic BR, Albanese AL, Freire-Maia B, Nunes FC, Souza PE, Gomez RS
Oral Maxillofac Surg 2011 Dec;15(4):233-7. Epub 2010 Jul 28 doi: 10.1007/s10006-010-0244-7. PMID: 20665061

Clinical prediction guides

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
Giant cell tumor of bone in an eighteenth-century Italian mummy.
Ventura L, Petrella E, Piciucchi S, Cilli E, Luiselli D, Feeney RNM, Traversari M
Virchows Arch 2021 Dec;479(6):1255-1261. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03192-5. PMID: 34462806Free PMC Article
SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.
Baněčková M, Agaimy A
Ann Diagn Pathol 2020 Jun;46:151510. Epub 2020 Apr 2 doi: 10.1016/j.anndiagpath.2020.151510. PMID: 32252013
METAPHYSEAL CORTICAL DEFECT AND TUMOR-LIKE PROCESSES OF LONG BONES (A LITERATURE REVIEW AND OWN OBSERVATIONS).
Lysenko N, Sharmazanova Y, Voronzhev I, Sorochan A, Kolomiychenko Y
Georgian Med News 2017 Jan;(262):4-14. PMID: 28252420
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article

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