U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-Ossifying Fibroma

MedGen UID:
569529
•Concept ID:
C0334067
•
Neoplastic Process
Synonyms: Fibrous cortical defect of bone; Metaphyseal fibrous defect; Non-ossifying fibroma
SNOMED CT: Metaphyseal fibrous defect (80415005); Non-ossifying fibroma (80415005); Fibrous cortical defect of bone (80415005)

Definition

A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Ossifying Fibroma

Professional guidelines

PubMed

Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.
Andreacchio A, Alberghina F, Testa G, Canavese F
Eur J Orthop Surg Traumatol 2018 Feb;28(2):291-297. Epub 2017 Aug 17 doi: 10.1007/s00590-017-2028-3. PMID: 28819829
Indication and procedure of the operative treatment of benign bone cysts in children and adolescents.
Baschang A, von Laer L
Eur J Pediatr Surg 1991 Aug;1(4):207-9. doi: 10.1055/s-2008-1042489. PMID: 1931839

Recent clinical studies

Etiology

Non-ossifying fibromas and fibrous cortical defects around the knee - an epidemiologic survey in a Japanese pediatric population.
Emori M, Tsuchie H, Teramoto A, Shimizu J, Mizushima E, Murahashi Y, Nagasawa H, Miyakoshi N, Yamashita T
BMC Musculoskelet Disord 2022 Apr 22;23(1):378. doi: 10.1186/s12891-022-05330-9. PMID: 35459158Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
Comparison of characteristic features and local recurrence in syndromic versus non-syndromic multifocal non-ossifying fibroma.
Jamshidi K, Motaghi P, Bagherifard A, Eigi M, Al-Baseesee HH, Mirzaei A
J Orthop Sci 2021 Jul;26(4):655-659. Epub 2020 Aug 17 doi: 10.1016/j.jos.2020.06.010. PMID: 32819790
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article
Tumor treated by endoscopy.
Choi Y, Kwak JM, Chung SH, Jung GH, Kim JD
Clin Orthop Surg 2014 Mar;6(1):72-9. Epub 2014 Feb 14 doi: 10.4055/cios.2014.6.1.72. PMID: 24605192Free PMC Article

Diagnosis

Co-Existence of Non-ossifying Fibroma and Osteoblastoma of the Tibia.
Alkan A, Ustabaşıoğlu FE, Usta U, Çiftdemir M, Üstün F
Balkan Med J 2023 Jan 23;40(1):66-67. Epub 2022 Dec 9 doi: 10.4274/balkanmedj.galenos.2022.2022-10-34. PMID: 36482109Free PMC Article
Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
Giant Cell-Rich Tumors of Bone.
Hartmann W, Harder D, Baumhoer D
Surg Pathol Clin 2021 Dec;14(4):695-706. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.010. PMID: 34742488
The non-ossifying fibroma: a case report and review of the literature.
Bowers LM, Cohen DM, Bhattacharyya I, Pettigrew JC Jr, Stavropoulos MF
Head Neck Pathol 2013 Jun;7(2):203-10. Epub 2012 Sep 25 doi: 10.1007/s12105-012-0399-7. PMID: 23008139Free PMC Article
Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review.
Mankin HJ, Trahan CA, Fondren G, Mankin CJ
Chir Organi Mov 2009 May;93(1):1-7. Epub 2009 Apr 29 doi: 10.1007/s12306-009-0016-4. PMID: 19711155

Therapy

Spectrum of histological features of Denosumab treated Giant Cell Tumor of Bone; potential pitfalls and diagnostic challenges for pathologists.
Tariq MU, Umer M, Khan Z, Saeed J, Siddiqui MA, Din NU
Ann Diagn Pathol 2020 Apr;45:151479. Epub 2020 Feb 14 doi: 10.1016/j.anndiagpath.2020.151479. PMID: 32088577
Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.
Andreacchio A, Alberghina F, Testa G, Canavese F
Eur J Orthop Surg Traumatol 2018 Feb;28(2):291-297. Epub 2017 Aug 17 doi: 10.1007/s00590-017-2028-3. PMID: 28819829
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases.
Ceroni D, Dayer R, De Coulon G, Kaelin A
Musculoskelet Surg 2011 Aug;95(2):107-14. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0115-x. PMID: 21409501
Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: a case report.
Sanatkumar S, Rajagopalan N, Mallikarjunaswamy B, Srinivasalu S, Sudhir NP, Usha K
J Orthop Surg (Hong Kong) 2005 Apr;13(1):83-7. doi: 10.1177/230949900501300116. PMID: 15872408

Prognosis

Giant cell tumor of bone in an eighteenth-century Italian mummy.
Ventura L, Petrella E, Piciucchi S, Cilli E, Luiselli D, Feeney RNM, Traversari M
Virchows Arch 2021 Dec;479(6):1255-1261. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03192-5. PMID: 34462806Free PMC Article
Pathological fracture in paediatric bone tumours and tumour-like lesions: A predictor of benign lesions?
Chaib B, Malhotra K, Khoo M, Saifuddin A
Br J Radiol 2021 Sep 1;94(1125):20201341. Epub 2021 Jul 28 doi: 10.1259/bjr.20201341. PMID: 34319796Free PMC Article
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article
Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.
Pobirci DD, Bogdan F, Pobirci O, Petcu CA, Roşca E
Rom J Morphol Embryol 2011;52(1 Suppl):385-8. PMID: 21424079
Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible.
Chrcanovic BR, Albanese AL, Freire-Maia B, Nunes FC, Souza PE, Gomez RS
Oral Maxillofac Surg 2011 Dec;15(4):233-7. Epub 2010 Jul 28 doi: 10.1007/s10006-010-0244-7. PMID: 20665061

Clinical prediction guides

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.
Baněčková M, Agaimy A
Ann Diagn Pathol 2020 Jun;46:151510. Epub 2020 Apr 2 doi: 10.1016/j.anndiagpath.2020.151510. PMID: 32252013
Non-ossifying fibroma of the right clavicle.
Eyesan SU, Katchy AU, Idowu OO, Adesina SA, Ayandele BO, Ano-Edward U
Niger Postgrad Med J 2018 Apr-Jun;25(2):126-129. doi: 10.4103/npmj.npmj_60_18. PMID: 30027926
METAPHYSEAL CORTICAL DEFECT AND TUMOR-LIKE PROCESSES OF LONG BONES (A LITERATURE REVIEW AND OWN OBSERVATIONS).
Lysenko N, Sharmazanova Y, Voronzhev I, Sorochan A, Kolomiychenko Y
Georgian Med News 2017 Jan;(262):4-14. PMID: 28252420
Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up.
Herget GW, Mauer D, Krauß T, El Tayeh A, Uhl M, Südkamp NP, Hauschild O
BMC Musculoskelet Disord 2016 Apr 5;17:147. doi: 10.1186/s12891-016-1004-0. PMID: 27044378Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...