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Chronic liver disease

MedGen UID:
574392
Concept ID:
C0341439
Disease or Syndrome
Synonym: Chronic Liver Disease
SNOMED CT: Chronic liver disease (328383001)

Definition

Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic liver disease

Professional guidelines

PubMed

Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS
Am J Gastroenterol 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. PMID: 35006099
Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

Recent clinical studies

Etiology

Maeso-Díaz R, Gracia-Sancho J
Semin Liver Dis 2020 Nov;40(4):373-384. Epub 2020 Nov 20 doi: 10.1055/s-0040-1715446. PMID: 33764489
Faulkes RE, Chauhan A, Knox E, Johnston T, Thompson F, Ferguson J
Aliment Pharmacol Ther 2020 Aug;52(3):420-429. Epub 2020 Jun 29 doi: 10.1111/apt.15908. PMID: 32598048
Palmer LB, Kuftinec G, Pearlman M, Green CH
Curr Gastroenterol Rep 2019 Jul 10;21(8):38. doi: 10.1007/s11894-019-0706-5. PMID: 31289936
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Diagnosis

Basthi Mohan P, Rajpurohit S, Musunuri B, Bhat G, Lochan R, Shetty S
Clin Chim Acta 2023 Feb 1;540:117215. Epub 2023 Jan 2 doi: 10.1016/j.cca.2022.117215. PMID: 36603656
Aller de la Fuente R
Clin Drug Investig 2022 Jun;42(Suppl 1):55-61. Epub 2022 Apr 29 doi: 10.1007/s40261-022-01141-x. PMID: 35484325Free PMC Article
Palmer LB, Kuftinec G, Pearlman M, Green CH
Curr Gastroenterol Rep 2019 Jul 10;21(8):38. doi: 10.1007/s11894-019-0706-5. PMID: 31289936
Goel V, Kar P
Trop Gastroenterol 2010 Apr-Jun;31(2):82-6. PMID: 20862980
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Therapy

Zhang C, Yang M
Int J Mol Sci 2021 Jul 15;22(14) doi: 10.3390/ijms22147571. PMID: 34299189Free PMC Article
Barchetta I, Cimini FA, Cavallo MG
Nutrients 2020 Oct 28;12(11) doi: 10.3390/nu12113302. PMID: 33126575Free PMC Article
Younossi ZM, Ratziu V, Loomba R, Rinella M, Anstee QM, Goodman Z, Bedossa P, Geier A, Beckebaum S, Newsome PN, Sheridan D, Sheikh MY, Trotter J, Knapple W, Lawitz E, Abdelmalek MF, Kowdley KV, Montano-Loza AJ, Boursier J, Mathurin P, Bugianesi E, Mazzella G, Olveira A, Cortez-Pinto H, Graupera I, Orr D, Gluud LL, Dufour JF, Shapiro D, Campagna J, Zaru L, MacConell L, Shringarpure R, Harrison S, Sanyal AJ; REGENERATE Study Investigators
Lancet 2019 Dec 14;394(10215):2184-2196. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)33041-7. PMID: 31813633
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Lee YA, Wallace MC, Friedman SL
Gut 2015 May;64(5):830-41. Epub 2015 Feb 13 doi: 10.1136/gutjnl-2014-306842. PMID: 25681399Free PMC Article

Prognosis

Perez Ruiz de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M
Crit Care 2022 Sep 26;26(1):289. doi: 10.1186/s13054-022-04163-1. PMID: 36163253Free PMC Article
Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS
Am J Gastroenterol 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. PMID: 35006099
Moon AM, Singal AG, Tapper EB
Clin Gastroenterol Hepatol 2020 Nov;18(12):2650-2666. Epub 2019 Aug 8 doi: 10.1016/j.cgh.2019.07.060. PMID: 31401364Free PMC Article
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J, Vos MB
Hepatology 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251. PMID: 30179269

Clinical prediction guides

Noureddin M, Truong E, Mayo R, Martínez-Arranz I, Mincholé I, Banales JM, Arrese M, Cusi K, Arias-Loste MT, Bruha R, Romero-Gómez M, Iruzubieta P, Aller R, Ampuero J, Calleja JL, Ibañez-Samaniego L, Aspichueta P, Martín-Duce A, Kushner T, Ortiz P, Harrison SA, Anstee QM, Crespo J, Mato JM, Sanyal AJ
Hepatology 2024 Jan 1;79(1):135-148. Epub 2023 Jul 24 doi: 10.1097/HEP.0000000000000542. PMID: 37505221Free PMC Article
DiLeo DA, Gidener T, Aytaman A
Curr Gastroenterol Rep 2023 Dec;25(12):390-400. Epub 2023 Nov 22 doi: 10.1007/s11894-023-00908-2. PMID: 37991713
Pons M, Augustin S, Scheiner B, Guillaume M, Rosselli M, Rodrigues SG, Stefanescu H, Ma MM, Mandorfer M, Mergeay-Fabre M, Procopet B, Schwabl P, Ferlitsch A, Semmler G, Berzigotti A, Tsochatzis E, Bureau C, Reiberger T, Bosch J, Abraldes JG, Genescà J
Am J Gastroenterol 2021 Apr;116(4):723-732. doi: 10.14309/ajg.0000000000000994. PMID: 33982942
Renzulli M, Clemente A, Brocchi S, Milandri M, Lucidi V, Vukotic R, Cappabianca S, Golfieri R
Eur J Gastroenterol Hepatol 2019 Mar;31(3):283-288. doi: 10.1097/MEG.0000000000001269. PMID: 30234643
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

En Li Cho E, Ang CZ, Quek J, Fu CE, Lim LKE, Heng ZEQ, Tan DJH, Lim WH, Yong JN, Zeng R, Chee D, Nah B, Lesmana CRA, Bwa AH, Win KM, Faulkner C, Aboona MB, Lim MC, Syn N, Kulkarni AV, Suzuki H, Takahashi H, Tamaki N, Wijarnpreecha K, Huang DQ, Muthiah M, Ng CH, Loomba R
Gut 2023 Nov;72(11):2138-2148. Epub 2023 Jul 25 doi: 10.1136/gutjnl-2023-330110. PMID: 37491159
Shah ND, Barritt AS 4th
Clin Ther 2022 May;44(5):682-696. Epub 2022 May 25 doi: 10.1016/j.clinthera.2022.04.012. PMID: 35643886
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, Qiu Y, Burns L, Afendy A, Nader F
J Hepatol 2019 Oct;71(4):793-801. Epub 2019 Jul 4 doi: 10.1016/j.jhep.2019.06.021. PMID: 31279902
Vernon G, Baranova A, Younossi ZM
Aliment Pharmacol Ther 2011 Aug;34(3):274-85. Epub 2011 May 30 doi: 10.1111/j.1365-2036.2011.04724.x. PMID: 21623852

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