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Chronic liver disease

MedGen UID:
574392
•Concept ID:
C0341439
•
Disease or Syndrome
Synonym: Chronic Liver Disease
SNOMED CT: Chronic liver disease (328383001)

Definition

Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic liver disease

Professional guidelines

PubMed

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management.
Long B, Lentz S, Koyfman A, Gottlieb M
Am J Emerg Med 2021 Jun;44:157-160. Epub 2021 Feb 16 doi: 10.1016/j.ajem.2021.02.015. PMID: 33626481
Cirrhosis: Diagnosis and Management.
Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

Recent clinical studies

Etiology

Non-invasive diagnosis and follow-up of chronic liver disease.
de Lédinghen V
Clin Res Hepatol Gastroenterol 2022 Jan;46(1):101763. Epub 2021 Jul 29 doi: 10.1016/j.clinre.2021.101763. PMID: 34332138
Aging and Chronic Liver Disease.
Maeso-Díaz R, Gracia-Sancho J
Semin Liver Dis 2020 Nov;40(4):373-384. Epub 2020 Nov 20 doi: 10.1055/s-0040-1715446. PMID: 33764489
Nutrition in Cirrhosis.
Palmer LB, Kuftinec G, Pearlman M, Green CH
Curr Gastroenterol Rep 2019 Jul 10;21(8):38. doi: 10.1007/s11894-019-0706-5. PMID: 31289936
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Transient elastography (FibroScan).
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Diagnosis

Chronic Liver Disease: Latest Research in Pathogenesis, Detection and Treatment.
De Siervi S, Cannito S, Turato C
Int J Mol Sci 2023 Jun 25;24(13) doi: 10.3390/ijms241310633. PMID: 37445809Free PMC Article
Nutrition and Chronic Liver Disease.
Aller de la Fuente R
Clin Drug Investig 2022 Jun;42(Suppl 1):55-61. Epub 2022 Apr 29 doi: 10.1007/s40261-022-01141-x. PMID: 35484325Free PMC Article
Non-invasive diagnosis and follow-up of chronic liver disease.
de Lédinghen V
Clin Res Hepatol Gastroenterol 2022 Jan;46(1):101763. Epub 2021 Jul 29 doi: 10.1016/j.clinre.2021.101763. PMID: 34332138
Nutrition in Cirrhosis.
Palmer LB, Kuftinec G, Pearlman M, Green CH
Curr Gastroenterol Rep 2019 Jul 10;21(8):38. doi: 10.1007/s11894-019-0706-5. PMID: 31289936
Transient elastography (FibroScan).
de Lédinghen V, Vergniol J
Gastroenterol Clin Biol 2008 Sep;32(6 Suppl 1):58-67. doi: 10.1016/S0399-8320(08)73994-0. PMID: 18973847

Therapy

Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.
Harrison SA, Taub R, Neff GW, Lucas KJ, Labriola D, Moussa SE, Alkhouri N, Bashir MR
Nat Med 2023 Nov;29(11):2919-2928. Epub 2023 Oct 16 doi: 10.1038/s41591-023-02603-1. PMID: 37845512Free PMC Article
Vitamin D and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): An Update.
Barchetta I, Cimini FA, Cavallo MG
Nutrients 2020 Oct 28;12(11) doi: 10.3390/nu12113302. PMID: 33126575Free PMC Article
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.
Younossi ZM, Ratziu V, Loomba R, Rinella M, Anstee QM, Goodman Z, Bedossa P, Geier A, Beckebaum S, Newsome PN, Sheridan D, Sheikh MY, Trotter J, Knapple W, Lawitz E, Abdelmalek MF, Kowdley KV, Montano-Loza AJ, Boursier J, Mathurin P, Bugianesi E, Mazzella G, Olveira A, Cortez-Pinto H, Graupera I, Orr D, Gluud LL, Dufour JF, Shapiro D, Campagna J, Zaru L, MacConell L, Shringarpure R, Harrison S, Sanyal AJ; REGENERATE Study Investigators
Lancet 2019 Dec 14;394(10215):2184-2196. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)33041-7. PMID: 31813633
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Pathobiology of liver fibrosis: a translational success story.
Lee YA, Wallace MC, Friedman SL
Gut 2015 May;64(5):830-41. Epub 2015 Feb 13 doi: 10.1136/gutjnl-2014-306842. PMID: 25681399Free PMC Article

Prognosis

Current status and future trends of the global burden of MASLD.
Miao L, Targher G, Byrne CD, Cao YY, Zheng MH
Trends Endocrinol Metab 2024 Aug;35(8):697-707. Epub 2024 Feb 29 doi: 10.1016/j.tem.2024.02.007. PMID: 38429161
Acute-on-Chronic Liver Failure Clinical Guidelines.
Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS
Am J Gastroenterol 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. PMID: 35006099
Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis.
Moon AM, Singal AG, Tapper EB
Clin Gastroenterol Hepatol 2020 Nov;18(12):2650-2666. Epub 2019 Aug 8 doi: 10.1016/j.cgh.2019.07.060. PMID: 31401364Free PMC Article
Burden of liver diseases in the world.
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.
Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J, Vos MB
Hepatology 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251. PMID: 30179269

Clinical prediction guides

Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF).
Noureddin M, Truong E, Mayo R, Martínez-Arranz I, Mincholé I, Banales JM, Arrese M, Cusi K, Arias-Loste MT, Bruha R, Romero-Gómez M, Iruzubieta P, Aller R, Ampuero J, Calleja JL, Ibañez-Samaniego L, Aspichueta P, Martín-Duce A, Kushner T, Ortiz P, Harrison SA, Anstee QM, Crespo J, Mato JM, Sanyal AJ
Hepatology 2024 Jan 1;79(1):135-148. Epub 2023 Jul 24 doi: 10.1097/HEP.0000000000000542. PMID: 37505221Free PMC Article
Chronic Liver Disease in the Older Patient-Evaluation and Management.
DiLeo DA, Gidener T, Aytaman A
Curr Gastroenterol Rep 2023 Dec;25(12):390-400. Epub 2023 Nov 22 doi: 10.1007/s11894-023-00908-2. PMID: 37991713
Prognostic Models in Acute-on-Chronic Liver Failure.
Goyes D, Trivedi HD, Curry MP
Clin Liver Dis 2023 Aug;27(3):681-690. Epub 2023 Apr 23 doi: 10.1016/j.cld.2023.03.011. PMID: 37380291
Noninvasive Diagnosis of Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease.
Pons M, Augustin S, Scheiner B, Guillaume M, Rosselli M, Rodrigues SG, Stefanescu H, Ma MM, Mandorfer M, Mergeay-Fabre M, Procopet B, Schwabl P, Ferlitsch A, Semmler G, Berzigotti A, Tsochatzis E, Bureau C, Reiberger T, Bosch J, Abraldes JG, Genescà J
Am J Gastroenterol 2021 Apr;116(4):723-732. doi: 10.14309/ajg.0000000000000994. PMID: 33982942
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis.
En Li Cho E, Ang CZ, Quek J, Fu CE, Lim LKE, Heng ZEQ, Tan DJH, Lim WH, Yong JN, Zeng R, Chee D, Nah B, Lesmana CRA, Bwa AH, Win KM, Faulkner C, Aboona MB, Lim MC, Syn N, Kulkarni AV, Suzuki H, Takahashi H, Tamaki N, Wijarnpreecha K, Huang DQ, Muthiah M, Ng CH, Loomba R
Gut 2023 Nov;72(11):2138-2148. Epub 2023 Jul 25 doi: 10.1136/gutjnl-2023-330110. PMID: 37491159
Nutrition as Therapy in Liver Disease.
Shah ND, Barritt AS 4th
Clin Ther 2022 May;44(5):682-696. Epub 2022 May 25 doi: 10.1016/j.clinthera.2022.04.012. PMID: 35643886
Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis.
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis.
Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, Qiu Y, Burns L, Afendy A, Nader F
J Hepatol 2019 Oct;71(4):793-801. Epub 2019 Jul 4 doi: 10.1016/j.jhep.2019.06.021. PMID: 31279902
Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis.
Li J, Zou B, Yeo YH, Feng Y, Xie X, Lee DH, Fujii H, Wu Y, Kam LY, Ji F, Li X, Chien N, Wei M, Ogawa E, Zhao C, Wu X, Stave CD, Henry L, Barnett S, Takahashi H, Furusyo N, Eguchi Y, Hsu YC, Lee TY, Ren W, Qin C, Jun DW, Toyoda H, Wong VW, Cheung R, Zhu Q, Nguyen MH
Lancet Gastroenterol Hepatol 2019 May;4(5):389-398. Epub 2019 Mar 20 doi: 10.1016/S2468-1253(19)30039-1. PMID: 30902670

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