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Non-Neoplastic Liver and Intrahepatic Bile Duct Disorder

MedGen UID:
317957
•Concept ID:
C1709250
•
Disease or Syndrome
Synonyms: Non-Neoplastic Hepatic Disease; Non-Neoplastic Hepatic Disorder

Definition

A non-neoplastic disorder that affects the liver parenchyma and the intrahepatic bile ducts. Representative examples include hepatitis, cirrhosis, and cholangitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Liver and Intrahepatic Bile Duct Disorder

Professional guidelines

PubMed

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions.
Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP
Virchows Arch 2006 Apr;448(4):407-11. Epub 2006 Jan 13 doi: 10.1007/s00428-005-0145-6. PMID: 16411132

Recent clinical studies

Therapy

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Deep learning-based clinical decision support system for gastric neoplasms in real-time endoscopy: development and validation study.
Gong EJ, Bang CS, Lee JJ, Baik GH, Lim H, Jeong JH, Choi SW, Cho J, Kim DY, Lee KB, Shin SI, Sigmund D, Moon BI, Park SC, Lee SH, Bang KB, Son DS
Endoscopy 2023 Aug;55(8):701-708. Epub 2023 Feb 8 doi: 10.1055/a-2031-0691. PMID: 36754065
Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease.
Gu H, Han SM, Park KK
Toxins (Basel) 2020 Mar 19;12(3) doi: 10.3390/toxins12030195. PMID: 32204567Free PMC Article
Targeted therapies in hepatocellular carcinoma.
Bronte F, Bronte G, Cusenza S, Fiorentino E, Rolfo C, Cicero G, Bronte E, Di Marco V, Firenze A, Angarano G, Fontana T, Russo A
Curr Med Chem 2014;21(8):966-74. doi: 10.2174/09298673113209990234. PMID: 23992323
Pediatric liver transplantation.
Starzl TE, Esquivel C, Gordon R, Todo S
Transplant Proc 1987 Aug;19(4):3230-5. PMID: 3303488Free PMC Article

Prognosis

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis.
Kriegsmann M, Kriegsmann K, Steinbuss G, Zgorzelski C, Albrecht T, Heinrich S, Farkas S, Roth W, Dang H, Hausen A, Gaida MM
Clin Transl Med 2023 Jul;13(7):e1299. doi: 10.1002/ctm2.1299. PMID: 37415390Free PMC Article
Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Clinical prediction guides

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis.
Kriegsmann M, Kriegsmann K, Steinbuss G, Zgorzelski C, Albrecht T, Heinrich S, Farkas S, Roth W, Dang H, Hausen A, Gaida MM
Clin Transl Med 2023 Jul;13(7):e1299. doi: 10.1002/ctm2.1299. PMID: 37415390Free PMC Article
Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Regression of portal hypertension: underlying mechanisms and therapeutic strategies.
Selicean S, Wang C, Guixé-Muntet S, Stefanescu H, Kawada N, Gracia-Sancho J
Hepatol Int 2021 Feb;15(1):36-50. Epub 2021 Feb 5 doi: 10.1007/s12072-021-10135-4. PMID: 33544313Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Dietary glycation compounds - implications for human health.
Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A
Crit Rev Toxicol 2024 Sep;54(8):485-617. Epub 2024 Aug 16 doi: 10.1080/10408444.2024.2362985. PMID: 39150724
Clinical features, natural history and outcomes of pseudolymphoma of liver: A case-series and systematic review.
Jiang W, Wu D, Li Q, Liu CH, Zeng Q, Chen E, Lu C, Tang H
Asian J Surg 2023 Feb;46(2):841-849. Epub 2022 Sep 16 doi: 10.1016/j.asjsur.2022.08.113. PMID: 36123208
Therapeutic approaches for portal biliopathy: A systematic review.
Franceschet I, Zanetto A, Ferrarese A, Burra P, Senzolo M
World J Gastroenterol 2016 Dec 7;22(45):9909-9920. doi: 10.3748/wjg.v22.i45.9909. PMID: 28018098Free PMC Article
Relationship between RUNX3 methylation and hepatocellular carcinoma in Asian populations: a systematic review.
Lu XX, Zhu LQ, Pang F, Sun W, Ou C, Li Y, Cao J, Hu YL
Genet Mol Res 2014 Jul 7;13(3):5182-9. doi: 10.4238/2014.July.7.11. PMID: 25061743

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