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Lip cancer

MedGen UID:
57548
•Concept ID:
C0153340
•
Neoplastic Process
Synonyms: Cancer of Lip; Cancer of the Lip; Cancer, Lip; Cancers, Lip; Lip Cancer; Lip Cancers
SNOMED CT: CA - Cancer of lip (363348004); Cancer of lip (363348004); Malignant tumor of lip (363348004)
 
Monarch Initiative: MONDO:0006834

Definition

A primary or metastatic malignant neoplasm involving the lip. [from NCI]

Professional guidelines

PubMed

Interstitial Brachytherapy for Lip Cancer: Technical Aspects to Individualize Treatment Approach and Optimize Outcomes.
Merfeld EC, Witek ME, Francis DM, Burr AR, Wallace CR, Kuczmarska-Haas A, Lamichhane N, Kimple RJ, Glazer TA, Wieland AM, McCulloch TM, Hartig GK, Harari PM
Pract Radiat Oncol 2023 Jul-Aug;13(4):340-345. Epub 2023 Jan 25 doi: 10.1016/j.prro.2023.01.004. PMID: 36709044Free PMC Article
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
Lip cancer: Reconsidering the at-risk patients with pathological assessment.
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Cancer and UV-radiation.
Osterlind A
Pharmacol Toxicol 1993;72 Suppl 1:67-8. doi: 10.1111/j.1600-0773.1993.tb01672.x. PMID: 8474993

Diagnosis

Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Brachytherapy in lip cancer.
Rovirosa-Casino A, Planas-Toledano I, Ferre-Jorge J, Oliva-Díez JM, Conill-Llobet C, Arenas-Prat M
Med Oral Patol Oral Cir Bucal 2006 May 1;11(3):E223-9. PMID: 16648757

Therapy

Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599
Cancer and UV-radiation.
Osterlind A
Pharmacol Toxicol 1993;72 Suppl 1:67-8. doi: 10.1111/j.1600-0773.1993.tb01672.x. PMID: 8474993

Prognosis

Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360
Brachytherapy in lip cancer.
Rovirosa-Casino A, Planas-Toledano I, Ferre-Jorge J, Oliva-Díez JM, Conill-Llobet C, Arenas-Prat M
Med Oral Patol Oral Cir Bucal 2006 May 1;11(3):E223-9. PMID: 16648757

Clinical prediction guides

A short review on DNA damage and repair effects in lip cancer.
Toprani SM, Kelkar Mane V
Hematol Oncol Stem Cell Ther 2021 Dec;14(4):267-274. Epub 2021 Feb 17 doi: 10.1016/j.hemonc.2021.01.007. PMID: 33626329
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
Lip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experience.
Biasoli ÉR, Valente VB, Mantovan B, Collado FU, Neto SC, Sundefeld ML, Miyahara GI, Bernabé DG
J Oral Maxillofac Surg 2016 Jul;74(7):1360-7. Epub 2016 Jan 30 doi: 10.1016/j.joms.2016.01.041. PMID: 26917204
Solar ultraviolet irradiance and cancer incidence and mortality.
Grant WB
Adv Exp Med Biol 2014;810:52-68. doi: 10.1007/978-1-4939-0437-2_4. PMID: 25207360

Recent systematic reviews

Lip Cancer: 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration A Systematic Review of 19,213 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.5).
Milano AF
J Insur Med 2023 Mar 7;49(4):1-12. doi: 10.17849/insm-49-4-1-12.1. PMID: 36883809
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis.
Varela-Centelles P, Gonzalez-Moles MÁ, Seoane-Romero J, Leira-Feijoo Y, Takkouche B, Seoane-Romero JM
Oral Dis 2022 Jan;28(1):57-65. Epub 2020 Oct 5 doi: 10.1111/odi.13643. PMID: 32945581
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis.
Santana T, Matuck B, Tenório JR, Braga MM
Med Oral Patol Oral Cir Bucal 2020 Jan 1;25(1):e106-e116. doi: 10.4317/medoral.23223. PMID: 31880283Free PMC Article
Malignant transformation of actinic cheilitis: A systematic review of observational studies.
Dancyger A, Heard V, Huang B, Suley C, Tang D, Ariyawardana A
J Investig Clin Dent 2018 Nov;9(4):e12343. Epub 2018 Jun 4 doi: 10.1111/jicd.12343. PMID: 29863311

Supplemental Content

Table of contents

    Clinical resources

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

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