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Lip carcinoma in situ

MedGen UID:
83849
•Concept ID:
C0347082
•
Neoplastic Process
Synonyms: Carcinoma in situ of Lip; carcinoma in situ of lip; Carcinoma in situ of the Lip; carcinoma in situ of the Lip; Lip Carcinoma in situ; lip carcinoma in situ; lip in situ carcinoma; Stage 0 Cancer of Lip; stage 0 cancer of Lip; Stage 0 Cancer of the Lip; stage 0 cancer of the Lip; Stage 0 Carcinoma of Lip; stage 0 carcinoma of Lip; Stage 0 Carcinoma of the Lip; stage 0 carcinoma of the Lip; Stage 0 Lip Cancer; stage 0 Lip cancer; Stage 0 Lip Cancer AJCC v6; stage 0 Lip cancer aJCC v6; Stage 0 Lip Cancer AJCC v6 and v7; stage 0 Lip cancer aJCC v6 and v7; Stage 0 Lip Cancer AJCC v7; stage 0 Lip cancer aJCC v7; Stage 0 Lip Carcinoma; stage 0 lip carcinoma
 
Monarch Initiative: MONDO:0004636

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip carcinoma in situ

Professional guidelines

PubMed

Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases.
Rossini RC, Dellatorre G, Mesquita LAF, Tarlé RG
J Dermatolog Treat 2021 Dec;32(8):1049-1052. Epub 2020 Feb 27 doi: 10.1080/09546634.2020.1724865. PMID: 32072836
Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience.
Mignogna MD, Lo Muzio L, Lo Russo L, Fedele S, Ruoppo E, Bucci E
Oral Oncol 2001 Apr;37(3):262-7. doi: 10.1016/s1368-8375(00)00096-8. PMID: 11287280

Recent clinical studies

Etiology

Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.
Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Invasive and in situ squamous cell carcinoma of the skin: a nationwide study in Iceland.
Adalsteinsson JA, Olafsdottir E, Ratner D, Waldman R, Feng H, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2021 Sep;185(3):537-547. Epub 2021 May 9 doi: 10.1111/bjd.19879. PMID: 33609287
Risk of lip cancer after solid organ transplantation in the United States.
Laprise C, Cahoon EK, Lynch CF, Kahn AR, Copeland G, Gonsalves L, Madeleine MM, Pfeiffer RM, Engels EA
Am J Transplant 2019 Jan;19(1):227-237. Epub 2018 Sep 5 doi: 10.1111/ajt.15052. PMID: 30074684Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Oral carcinoma in situ.
Waldron CA, Shafer WG
Oral Surg Oral Med Oral Pathol 1975 Feb;39(2):227-38. doi: 10.1016/0030-4220(75)90224-8. PMID: 1054449

Diagnosis

Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.
Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Sebaceous Carcinoma of the Vulva: An Unexpected Diagnosis and Literature Review.
Rocha AC, Sá MI, Abrantes C, Sousa R
Acta Med Port 2022 Jan 3;35(1):63-67. doi: 10.20344/amp.13551. PMID: 35225764
Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.
Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ
J Nucl Med 2021 Jul 1;62(7):949-955. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.252460. PMID: 33246980Free PMC Article
Oral carcinoma in situ.
Waldron CA, Shafer WG
Oral Surg Oral Med Oral Pathol 1975 Feb;39(2):227-38. doi: 10.1016/0030-4220(75)90224-8. PMID: 1054449

Therapy

5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Wang P, Zhang G, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X
Photodiagnosis Photodyn Ther 2021 Sep;35:102321. Epub 2021 May 17 doi: 10.1016/j.pdpdt.2021.102321. PMID: 34015543
Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.
Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ
J Nucl Med 2021 Jul 1;62(7):949-955. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.252460. PMID: 33246980Free PMC Article
Risk of lip cancer after solid organ transplantation in the United States.
Laprise C, Cahoon EK, Lynch CF, Kahn AR, Copeland G, Gonsalves L, Madeleine MM, Pfeiffer RM, Engels EA
Am J Transplant 2019 Jan;19(1):227-237. Epub 2018 Sep 5 doi: 10.1111/ajt.15052. PMID: 30074684Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Leukoplakia of the labial commissure.
Hogewind WF, van der Waal I
Br J Oral Maxillofac Surg 1988 Apr;26(2):133-40. doi: 10.1016/0266-4356(88)90008-3. PMID: 3285887

Prognosis

Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.
Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ
J Nucl Med 2021 Jul 1;62(7):949-955. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.252460. PMID: 33246980Free PMC Article
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.
Knuutila JS, Riihilä P, Kurki S, Nissinen L, Kähäri VM
Acta Derm Venereol 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628. PMID: 32930344Free PMC Article
Risk of lip cancer after solid organ transplantation in the United States.
Laprise C, Cahoon EK, Lynch CF, Kahn AR, Copeland G, Gonsalves L, Madeleine MM, Pfeiffer RM, Engels EA
Am J Transplant 2019 Jan;19(1):227-237. Epub 2018 Sep 5 doi: 10.1111/ajt.15052. PMID: 30074684Free PMC Article
Head and neck in situ carcinoma: incidence, trends, and survival.
Reid BC, Winn DM, Morse DE, Pendrys DG
Oral Oncol 2000 Sep;36(5):414-20. doi: 10.1016/s1368-8375(00)00028-2. PMID: 10964047
Biology and pathological associations of the human papillomaviruses: a review.
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257

Clinical prediction guides

Oncologic Outcomes for Squamous Cell Carcinoma In Situ With a Clinically Resolved Biopsy Site Managed by Watchful Waiting.
Logan S, Porter HJ, Lowry J, Carpenter C, Seward DJ, Holmes T, Goldman G, Bui MR
Dermatol Surg 2024 Aug 1;50(8):710-713. Epub 2024 May 9 doi: 10.1097/DSS.0000000000004202. PMID: 38722701
Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.
Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ
J Nucl Med 2021 Jul 1;62(7):949-955. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.252460. PMID: 33246980Free PMC Article
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases.
Rossini RC, Dellatorre G, Mesquita LAF, Tarlé RG
J Dermatolog Treat 2021 Dec;32(8):1049-1052. Epub 2020 Feb 27 doi: 10.1080/09546634.2020.1724865. PMID: 32072836
Grading oral epithelial dysplasia: analysis of individual features.
Tilakaratne WM, Sherriff M, Morgan PR, Odell EW
J Oral Pathol Med 2011 Aug;40(7):533-40. Epub 2011 Apr 18 doi: 10.1111/j.1600-0714.2011.01033.x. PMID: 21501232

Recent systematic reviews

Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.
Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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