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Cheek mucosa cancer

MedGen UID:
57550
•Concept ID:
C0153373
•
Neoplastic Process
Synonyms: buccal mucosa cancer; CA - Cancer of buccal mucosa; CA - Cancer of cheek mucosa; Cancer of buccal mucosa; cancer of buccal mucosa; Cancer of cheek mucosa; cheek mucosa cancer; Malignant Buccal Mucosa Neoplasm; malignant buccal mucosa neoplasm; Malignant Buccal Mucosa Tumor; malignant buccal mucosa tumor; malignant buccal mucosa tumour; Malignant Neoplasm of Buccal Mucosa; malignant neoplasm of buccal mucosa; malignant neoplasm of cheek, inner aspect; Malignant Neoplasm of the Buccal Mucosa; malignant neoplasm of the buccal mucosa; Malignant tumor of buccal mucosa; Malignant Tumor of Buccal Mucosa; malignant tumor of buccal mucosa; Malignant tumor of cheek mucosa; Malignant tumor of internal cheek; Malignant Tumor of the Buccal Mucosa; malignant tumor of the buccal mucosa; malignant tumour of buccal mucosa; malignant tumour of the buccal mucosa
SNOMED CT: Malignant tumor of internal cheek (363386008); Malignant tumor of cheek mucosa (363386008); CA - Cancer of cheek mucosa (363386008); CA - Cancer of buccal mucosa (363386008); Cancer of cheek mucosa (363386008); Cancer of buccal mucosa (363386008); Malignant tumor of buccal mucosa (363386008)
 
Monarch Initiative: MONDO:0004645

Definition

A primary or metastatic malignant neoplasm involving the buccal mucosa. [from NCI]

Professional guidelines

PubMed

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Early side effects of radiation treatment for head and neck cancer.
Brook I
Cancer Radiother 2021 Jul;25(5):507-513. Epub 2021 Mar 5 doi: 10.1016/j.canrad.2021.02.001. PMID: 33685809
Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies.
Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST
CA Cancer J Clin 2022 Jan;72(1):57-77. Epub 2021 Oct 29 doi: 10.3322/caac.21704. PMID: 34714553
Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis.
Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M
Int J Environ Res Public Health 2020 Dec 8;17(24) doi: 10.3390/ijerph17249160. PMID: 33302498Free PMC Article
Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients.
Huang CJ, Huang MY, Fang PT, Chen F, Wang YT, Chen CH, Yuan SS, Huang CM, Luo KH, Chuang HY, Wang YY, Lee HH
Am J Clin Nutr 2019 Mar 1;109(3):606-614. doi: 10.1093/ajcn/nqy329. PMID: 30753262Free PMC Article
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Oral mucositis.
Raber-Durlacher JE, Elad S, Barasch A
Oral Oncol 2010 Jun;46(6):452-6. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.03.012. PMID: 20403721

Diagnosis

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies.
Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST
CA Cancer J Clin 2022 Jan;72(1):57-77. Epub 2021 Oct 29 doi: 10.3322/caac.21704. PMID: 34714553
Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis.
Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M
Int J Environ Res Public Health 2020 Dec 8;17(24) doi: 10.3390/ijerph17249160. PMID: 33302498Free PMC Article
Oral Microbiome and Cancer Therapy-Induced Oral Mucositis.
Mougeot JC, Stevens CB, Morton DS, Brennan MT, Mougeot FB
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz002. PMID: 31425594
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H
Cancer Discov 2019 Jul;9(7):852-871. Epub 2019 May 3 doi: 10.1158/2159-8290.CD-18-1522. PMID: 31053628
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Therapy

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies.
Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST
CA Cancer J Clin 2022 Jan;72(1):57-77. Epub 2021 Oct 29 doi: 10.3322/caac.21704. PMID: 34714553
Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis.
Yuwanati M, Gondivkar S, Sarode SC, Gadbail A, Desai A, Mhaske S, Pathak SK, N Khatib M
Future Oncol 2021 Mar;17(8):979-990. Epub 2021 Feb 5 doi: 10.2217/fon-2020-0881. PMID: 33541115
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments.
Shen YW, Shih YH, Fuh LJ, Shieh TM
Int J Mol Sci 2020 Sep 30;21(19) doi: 10.3390/ijms21197231. PMID: 33008091Free PMC Article
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H
Cancer Discov 2019 Jul;9(7):852-871. Epub 2019 May 3 doi: 10.1158/2159-8290.CD-18-1522. PMID: 31053628
Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients.
Huang CJ, Huang MY, Fang PT, Chen F, Wang YT, Chen CH, Yuan SS, Huang CM, Luo KH, Chuang HY, Wang YY, Lee HH
Am J Clin Nutr 2019 Mar 1;109(3):606-614. doi: 10.1093/ajcn/nqy329. PMID: 30753262Free PMC Article

Prognosis

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.
Parakh MK, Ulaganambi S, Ashifa N, Premkumar R, Jain AL
Eur J Cancer Prev 2020 Jan;29(1):65-72. doi: 10.1097/CEJ.0000000000000510. PMID: 30921006
Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Oral erythroplakia-What is it?
Holmstrup P
Oral Dis 2018 Mar;24(1-2):138-143. doi: 10.1111/odi.12709. PMID: 29480616
Integrins and oral cancer.
Thomas GJ, Jones J, Speight PM
Oral Oncol 1997 Nov;33(6):381-8. doi: 10.1016/s0964-1955(97)00021-3. PMID: 9509120
Erythroplakia: the dangerous red mucosa.
Bouquot JE, Ephros H
Pract Periodontics Aesthet Dent 1995 Aug;7(6):59-67; quiz 68. PMID: 9002888

Clinical prediction guides

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis.
Bruno JS, Al-Qadami GH, Laheij AMGA, Bossi P, Fregnani ER, Wardill HR
Int J Mol Sci 2023 May 5;24(9) doi: 10.3390/ijms24098274. PMID: 37175980Free PMC Article
The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies.
Elad S, Yarom N, Zadik Y, Kuten-Shorrer M, Sonis ST
CA Cancer J Clin 2022 Jan;72(1):57-77. Epub 2021 Oct 29 doi: 10.3322/caac.21704. PMID: 34714553
Oral submucous fibrosis: An enigmatic morpho-insight.
Hande AH, Chaudhary MS, Gawande MN, Gadbail AR, Zade PR, Bajaj S, Patil SK, Tekade S
J Cancer Res Ther 2019 Jul-Sep;15(3):463-469. doi: 10.4103/jcrt.JCRT_522_17. PMID: 31169205
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H
Cancer Discov 2019 Jul;9(7):852-871. Epub 2019 May 3 doi: 10.1158/2159-8290.CD-18-1522. PMID: 31053628
Alcohol-related diseases of the mouth and throat.
Riedel F, Goessler UR, Hormann K
Dig Dis 2005;23(3-4):195-203. doi: 10.1159/000090166. PMID: 16508283

Recent systematic reviews

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Raman spectroscopy in oral cavity and oropharyngeal cancer: a systematic review.
Faur CI, Falamas A, Chirila M, Roman RC, Rotaru H, Moldovan MA, Albu S, Baciut M, Robu I, Hedesiu M
Int J Oral Maxillofac Surg 2022 Nov;51(11):1373-1381. Epub 2022 Mar 10 doi: 10.1016/j.ijom.2022.02.015. PMID: 35282942
Oral Mucosal Melanoma.
Nisi M, Izzetti R, Gennai S, Pucci A, Lenzi C, Graziani F
J Craniofac Surg 2022 May 1;33(3):830-834. Epub 2021 Jul 30 doi: 10.1097/SCS.0000000000008054. PMID: 34334749
Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis.
Yuwanati M, Gondivkar S, Sarode SC, Gadbail A, Desai A, Mhaske S, Pathak SK, N Khatib M
Future Oncol 2021 Mar;17(8):979-990. Epub 2021 Feb 5 doi: 10.2217/fon-2020-0881. PMID: 33541115
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

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