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Brainstem cancer

MedGen UID:
57566
•Concept ID:
C0153641
•
Neoplastic Process
Synonyms: brain stem cancer; brainstem cancer; cancer of brainstem; Malignant Brain Stem Neoplasm; Malignant Brain Stem Tumor; Malignant Brainstem Neoplasm; Malignant Brainstem Tumor; Malignant Neoplasm of Brain Stem; malignant neoplasm of brain stem; Malignant neoplasm of brainstem; Malignant Neoplasm of Brainstem; malignant neoplasm of brainstem; Malignant Neoplasm of the Brain Stem; malignant neoplasm of the brain stem; Malignant Neoplasm of the Brainstem; malignant neoplasm of the brainstem; Malignant Tumor of Brain Stem; malignant tumor of brain stem; Malignant Tumor of Brainstem; malignant tumor of brainstem; Malignant Tumor of the Brain Stem; malignant tumor of the brain stem; Malignant Tumor of the Brainstem; malignant tumor of the brainstem; malignant tumour of brain stem; malignant tumour of brainstem; malignant tumour of the brain stem; malignant tumour of the brainstem
SNOMED CT: Malignant neoplasm of brainstem (363473003)
 
Monarch Initiative: MONDO:0002912

Definition

A primary or metastatic malignant neoplasm that affects the brain stem. [from NCI]

Professional guidelines

PubMed

OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma.
Thomas L, Smith N, Saunders D, Zalles M, Gulej R, Lerner M, Fung KM, Carcaboso AM, Towner RA
J Transl Med 2020 Nov 10;18(1):424. doi: 10.1186/s12967-020-02593-5. PMID: 33168005Free PMC Article

Recent clinical studies

Etiology

Endoscopic transventricular biopsy in brainstem diffuse midline glioma: how I do it.
La Corte E, Babini M, Bortoluzzi G, Zucchelli M
Acta Neurochir (Wien) 2023 Apr;165(4):1099-1103. Epub 2022 Dec 8 doi: 10.1007/s00701-022-05443-z. PMID: 36481874
Progress in diffuse intrinsic pontine glioma: advocating for stereotactic biopsy in the standard of care.
Williams JR, Young CC, Vitanza NA, McGrath M, Feroze AH, Browd SR, Hauptman JS
Neurosurg Focus 2020 Jan 1;48(1):E4. doi: 10.3171/2019.9.FOCUS19745. PMID: 31896081
Central neurogenic hyperventilation and renal tubular acidosis in children with pontine gliomas.
Ledet D, Delos Santos NM, Khan R, Gajjar A, Broniscer A
Neurology 2014 Mar 25;82(12):1099-100. Epub 2014 Feb 14 doi: 10.1212/WNL.0000000000000252. PMID: 24532275Free PMC Article

Diagnosis

Endoscopic transventricular biopsy in brainstem diffuse midline glioma: how I do it.
La Corte E, Babini M, Bortoluzzi G, Zucchelli M
Acta Neurochir (Wien) 2023 Apr;165(4):1099-1103. Epub 2022 Dec 8 doi: 10.1007/s00701-022-05443-z. PMID: 36481874

Therapy

Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies.
Meel MH, Sewing ACP, Waranecki P, Metselaar DS, Wedekind LE, Koster J, van Vuurden DG, Kaspers GJL, Hulleman E
Exp Cell Res 2017 Nov 15;360(2):397-403. Epub 2017 Sep 22 doi: 10.1016/j.yexcr.2017.09.032. PMID: 28947132

Prognosis

Endoscopic transventricular biopsy in brainstem diffuse midline glioma: how I do it.
La Corte E, Babini M, Bortoluzzi G, Zucchelli M
Acta Neurochir (Wien) 2023 Apr;165(4):1099-1103. Epub 2022 Dec 8 doi: 10.1007/s00701-022-05443-z. PMID: 36481874
OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma.
Thomas L, Smith N, Saunders D, Zalles M, Gulej R, Lerner M, Fung KM, Carcaboso AM, Towner RA
J Transl Med 2020 Nov 10;18(1):424. doi: 10.1186/s12967-020-02593-5. PMID: 33168005Free PMC Article

Clinical prediction guides

Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies.
Meel MH, Sewing ACP, Waranecki P, Metselaar DS, Wedekind LE, Koster J, van Vuurden DG, Kaspers GJL, Hulleman E
Exp Cell Res 2017 Nov 15;360(2):397-403. Epub 2017 Sep 22 doi: 10.1016/j.yexcr.2017.09.032. PMID: 28947132

Supplemental Content

Table of contents

    Clinical resources

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