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Anaplastic Brain Stem Astrocytoma

MedGen UID:
233983
•Concept ID:
C1332279
•
Neoplastic Process
Synonym: Anaplastic Brainstem Astrocytoma

Definition

An anaplastic astrocytoma that arises from the brain stem. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Brain Stem Astrocytoma

Professional guidelines

PubMed

Tectal gliomas: assessment of malignant progression, clinical management, and quality of life in a supposedly benign neoplasm.
Mohme M, Fritzsche FS, Mende KC, Matschke J, Löbel U, Kammler G, Westphal M, Emami P, Martens T
Neurosurg Focus 2018 Jun;44(6):E15. doi: 10.3171/2018.3.FOCUS1850. PMID: 29852760
Natural history and management of brainstem gliomas in adults. A retrospective Italian study.
Salmaggi A, Fariselli L, Milanesi I, Lamperti E, Silvani A, Bizzi A, Maccagnano E, Trevisan E, Laguzzi E, Rudà R, Boiardi A, Soffietti R; Associazione Italiana di Neuro-oncologia
J Neurol 2008 Feb;255(2):171-7. Epub 2008 Feb 25 doi: 10.1007/s00415-008-0589-0. PMID: 18293027
Valproic acid for the treatment of pediatric malignant glioma.
Driever PH, Knüpfer MM, Cinatl J, Wolff JE
Klin Padiatr 1999 Jul-Aug;211(4):323-8. doi: 10.1055/s-2008-1043809. PMID: 10472571

Recent clinical studies

Etiology

Diffuse Gliomas of the Brainstem and Cerebellum in Adults Show Molecular Heterogeneity.
Eschbacher KL, Ida CM, Johnson DR, Alvi MA, Jenkins SM, Ruff MW, Kerezoudis P, Neth BJ, Pasion RM, Daniels DJ, Kizilbash SH, Raghunathan A
Am J Surg Pathol 2021 Aug 1;45(8):1082-1090. doi: 10.1097/PAS.0000000000001690. PMID: 33606385
High-grade glioma in children and adolescents: a single-center experience.
Yazici G, Zorlu F, Cengiz M, Ozyigit G, Eren G, Yüce D, Varan A, Akyuz C, Akalan N, Gurkaynak M
Childs Nerv Syst 2016 Feb;32(2):291-7. Epub 2015 Dec 17 doi: 10.1007/s00381-015-2980-3. PMID: 26679932
Radiotherapy for high-grade gliomas. Does altered fractionation improve the outcome?
Nieder C, Andratschke N, Wiedenmann N, Busch R, Grosu AL, Molls M
Strahlenther Onkol 2004 Jul;180(7):401-7. doi: 10.1007/s00066-004-1220-7. PMID: 15241527
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306
Pathologic analysis of primary brain tumors.
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Diagnosis

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
Paediatric brain-stem gliomas: MRI, FDG-PET and histological grading correlation.
Kwon JW, Kim IO, Cheon JE, Kim WS, Moon SG, Kim TJ, Chi JG, Wang KC, Chung JK, Yeon KM
Pediatr Radiol 2006 Sep;36(9):959-64. Epub 2006 Jul 18 doi: 10.1007/s00247-006-0256-5. PMID: 16847598
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306

Therapy

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306
Chemotherapy for brain tumors.
Pech IV, Peterson K, Cairncross JG
Oncology (Williston Park) 1998 Apr;12(4):537-43, 547; discussion 547-8, 553. PMID: 9575527

Prognosis

Bilateral thalamic and brainstem anaplastic astrocytoma: A case report.
Zhang H, Zhang P, Nie H, Zhang J, Li J, Lu X, Shen Y
Medicine (Baltimore) 2024 Feb 2;103(5):e37136. doi: 10.1097/MD.0000000000037136. PMID: 38306557Free PMC Article
Differential expression of stem cell markers in proliferating cells in glioma.
Rehfeld M, Matschke J, Hagel C, Willenborg K, Glatzel M, Bernreuther C
J Cancer Res Clin Oncol 2021 Oct;147(10):2969-2982. Epub 2021 Jun 25 doi: 10.1007/s00432-021-03704-5. PMID: 34170383Free PMC Article
Paediatric brain-stem gliomas: MRI, FDG-PET and histological grading correlation.
Kwon JW, Kim IO, Cheon JE, Kim WS, Moon SG, Kim TJ, Chi JG, Wang KC, Chung JK, Yeon KM
Pediatr Radiol 2006 Sep;36(9):959-64. Epub 2006 Jul 18 doi: 10.1007/s00247-006-0256-5. PMID: 16847598
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Pathologic analysis of primary brain tumors.
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Clinical prediction guides

DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy.
Trkova K, Sumerauer D, Krskova L, Vicha A, Koblizek M, Votava T, Priban V, Zapotocky M
Childs Nerv Syst 2023 Sep;39(9):2509-2513. Epub 2023 May 11 doi: 10.1007/s00381-023-05976-3. PMID: 37165121Free PMC Article
Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
The Astrogenic Balance in the Aging Brain.
Andromidas F, Atashpanjeh S, Myers AJ, MacKinnon BE, Shaffer MM, Koob AO
Curr Neuropharmacol 2021;19(11):1952-1965. doi: 10.2174/1570159X19666210420095118. PMID: 33881971Free PMC Article
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306

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