U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anaplastic Brain Stem Glioma

MedGen UID:
231067
•Concept ID:
C1332280
•
Neoplastic Process
Synonyms: Anaplastic Brainstem Glioma; Anaplastic Glioma of Brain Stem; Anaplastic Glioma of Brainstem; Anaplastic Glioma of the Brain Stem; Anaplastic Glioma of the Brainstem; Brain Stem Glioma, Grade III; Brainstem Glioma, Grade III; Grade 3 Brain Stem Glioma; Grade 3 Brainstem Glioma; Grade 3 Glioma of Brain Stem; Grade 3 Glioma of Brainstem; Grade 3 Glioma of the Brain Stem; Grade 3 Glioma of the Brainstem; Grade III Brain Stem Glioma; Grade III Brainstem Glioma; Grade III Glioma of Brain Stem; Grade III Glioma of Brainstem; Grade III Glioma of the Brain Stem; Grade III Glioma of the Brainstem; Undifferentiated Brain Stem Glioma; Undifferentiated Brainstem Glioma; Undifferentiated Glioma of Brain Stem; Undifferentiated Glioma of Brainstem; Undifferentiated Glioma of the Brain Stem; Undifferentiated Glioma of the Brainstem

Definition

An anaplastic glioma that arises from the brain stem. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Brain Stem Glioma

Professional guidelines

PubMed

Tectal gliomas: assessment of malignant progression, clinical management, and quality of life in a supposedly benign neoplasm.
Mohme M, Fritzsche FS, Mende KC, Matschke J, Löbel U, Kammler G, Westphal M, Emami P, Martens T
Neurosurg Focus 2018 Jun;44(6):E15. doi: 10.3171/2018.3.FOCUS1850. PMID: 29852760
New concepts in the management of diffuse low-grade glioma: Proposal of a multistage and individualized therapeutic approach.
Duffau H, Taillandier L
Neuro Oncol 2015 Mar;17(3):332-42. Epub 2014 Aug 2 doi: 10.1093/neuonc/nou153. PMID: 25087230Free PMC Article
Childhood medulloblastoma: current status of biology and treatment.
Klesse LJ, Bowers DC
CNS Drugs 2010 Apr;24(4):285-301. doi: 10.2165/11530140-000000000-00000. PMID: 20297854

Recent clinical studies

Etiology

The Spectrum of Underlying Diseases in Children with Torticollis.
Tumturk A, Gorkem SB, Ozmansur EN, Peduk Y, Arslan U, Gok V, Dogan H, Cetin BS, Sahin A, Gumus H, Guney A, Unal E, Kurtsoy A, Per H
Turk Neurosurg 2021;31(3):389-398. doi: 10.5137/1019-5149.JTN.31359-20.2. PMID: 33759163
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas.
Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C
Nat Commun 2019 Sep 25;10(1):4343. doi: 10.1038/s41467-019-12187-5. PMID: 31554817Free PMC Article
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation.
Cambruzzi E
Childs Nerv Syst 2018 May;34(5):809-815. Epub 2018 Mar 26 doi: 10.1007/s00381-018-3765-2. PMID: 29582169
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M
Nature 2017 Sep 28;549(7673):533-537. Epub 2017 Sep 20 doi: 10.1038/nature24014. PMID: 28959975Free PMC Article

Diagnosis

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
The Spectrum of Underlying Diseases in Children with Torticollis.
Tumturk A, Gorkem SB, Ozmansur EN, Peduk Y, Arslan U, Gok V, Dogan H, Cetin BS, Sahin A, Gumus H, Guney A, Unal E, Kurtsoy A, Per H
Turk Neurosurg 2021;31(3):389-398. doi: 10.5137/1019-5149.JTN.31359-20.2. PMID: 33759163
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Molecular diagnostics in embryonal brain tumors.
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article

Therapy

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial.
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306
Chemotherapy for brain tumors.
Pech IV, Peterson K, Cairncross JG
Oncology (Williston Park) 1998 Apr;12(4):537-43, 547; discussion 547-8, 553. PMID: 9575527

Prognosis

Differential expression of stem cell markers in proliferating cells in glioma.
Rehfeld M, Matschke J, Hagel C, Willenborg K, Glatzel M, Bernreuther C
J Cancer Res Clin Oncol 2021 Oct;147(10):2969-2982. Epub 2021 Jun 25 doi: 10.1007/s00432-021-03704-5. PMID: 34170383Free PMC Article
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation.
Cambruzzi E
Childs Nerv Syst 2018 May;34(5):809-815. Epub 2018 Mar 26 doi: 10.1007/s00381-018-3765-2. PMID: 29582169
Radiotherapy for high-grade gliomas. Does altered fractionation improve the outcome?
Nieder C, Andratschke N, Wiedenmann N, Busch R, Grosu AL, Molls M
Strahlenther Onkol 2004 Jul;180(7):401-7. doi: 10.1007/s00066-004-1220-7. PMID: 15241527
Chemotherapy of anaplastic oligodendroglial tumours.
Soffietti R
Expert Opin Pharmacother 2004 Feb;5(2):295-306. doi: 10.1517/14656566.5.2.295. PMID: 14996626
Pathologic analysis of primary brain tumors.
McComb RD, Burger PC
Neurol Clin 1985 Nov;3(4):711-28. PMID: 3001488

Clinical prediction guides

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318
The Astrogenic Balance in the Aging Brain.
Andromidas F, Atashpanjeh S, Myers AJ, MacKinnon BE, Shaffer MM, Koob AO
Curr Neuropharmacol 2021;19(11):1952-1965. doi: 10.2174/1570159X19666210420095118. PMID: 33881971Free PMC Article
Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas.
Zhao YY, Wan QS, Hao Z, Zhu HX, Xing ZL, Li MH
Medicine (Baltimore) 2020 Mar;99(10):e19416. doi: 10.1097/MD.0000000000019416. PMID: 32150092Free PMC Article
Valproic acid for the treatment of pediatric malignant glioma.
Driever PH, Knüpfer MM, Cinatl J, Wolff JE
Klin Padiatr 1999 Jul-Aug;211(4):323-8. doi: 10.1055/s-2008-1043809. PMID: 10472571
Brain biopsy using high-field strength interventional magnetic resonance imaging.
Hall WA, Martin AJ, Liu H, Nussbaum ES, Maxwell RE, Truwit CL
Neurosurgery 1999 Apr;44(4):807-13; discussion 813-4. doi: 10.1097/00006123-199904000-00067. PMID: 10201306

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...