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Keratoacanthoma

MedGen UID:
5954
Concept ID:
C0022572
Neoplastic Process
Synonym: Keratoacanthomas
SNOMED CT: Keratoacanthoma of skin (417264005); Keratoacanthoma (254662007); Molluscum sebaceum (254662007); KA - Keratoacanthoma (254662007)
 
HPO: HP:0031525
Monarch Initiative: MONDO:0002527

Definition

Keratoacanthoma (KA) is a common benign epithelial tumor that originates from the pilosebaceous glands. In most cases, it is characterized by rapid evolution, followed by spontaneous resolution over 4 to 6 months. KA usually presents as a solitary flesh-coloured nodule with a central keratin plug on the sun-exposed skin of elderly individuals. [from HPO]

Conditions with this feature

Xeroderma pigmentosum, group F
MedGen UID:
120612
Concept ID:
C0268140
Congenital Abnormality
Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).

Professional guidelines

PubMed

Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Kiss N, Avci P, Bánvölgyi A, Lőrincz K, Szakonyi J, Gyöngyösi N, Fésűs L, Lee G, Wikonkál N
Dermatol Ther 2019 May;32(3):e12872. Epub 2019 Apr 4 doi: 10.1111/dth.12872. PMID: 30866135
Nofal A, Assaf M, Nofal E, Alradi M
J Eur Acad Dermatol Venereol 2014 Apr;28(4):397-404. Epub 2013 Aug 6 doi: 10.1111/jdv.12226. PMID: 23919932

Recent clinical studies

Etiology

Machado RA, Oliveira LQ, Martelli-Júnior H, Pires FR, Carvas JB, Rogerio VE, Rabelo VD, Coletta RD
Med Oral Patol Oral Cir Bucal 2023 May 1;28(3):e278-e284. doi: 10.4317/medoral.25713. PMID: 36565218Free PMC Article
Kawaguchi M, Kato H, Matsuo M
Radiol Med 2019 Oct;124(10):1049-1061. Epub 2019 Jul 3 doi: 10.1007/s11547-019-01060-6. PMID: 31270724
Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, Chiarion-Sileni V, Drucis K, Krajsova I, Hauschild A, Lorigan P, Wolter P, Long GV, Flaherty K, Nathan P, Ribas A, Martin AM, Sun P, Crist W, Legos J, Rubin SD, Little SM, Schadendorf D
N Engl J Med 2015 Jan 1;372(1):30-9. Epub 2014 Nov 16 doi: 10.1056/NEJMoa1412690. PMID: 25399551
Ascierto PA, Kirkwood JM, Grob JJ, Simeone E, Grimaldi AM, Maio M, Palmieri G, Testori A, Marincola FM, Mozzillo N
J Transl Med 2012 Jul 9;10:85. doi: 10.1186/1479-5876-10-85. PMID: 22554099Free PMC Article
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA; BRIM-3 Study Group
N Engl J Med 2011 Jun 30;364(26):2507-16. Epub 2011 Jun 5 doi: 10.1056/NEJMoa1103782. PMID: 21639808Free PMC Article

Diagnosis

Xiao H, Hooper PB, Umphress BA, Wolverton JE
Dermatol Online J 2021 Mar 15;27(3) PMID: 33865282
Tisack A, Fotouhi A, Fidai C, Friedman BJ, Ozog D, Veenstra J
Br J Dermatol 2021 Sep;185(3):487-498. Epub 2021 Jun 14 doi: 10.1111/bjd.20389. PMID: 33864244
Takai T
J Dermatol 2017 Mar;44(3):304-314. doi: 10.1111/1346-8138.13696. PMID: 28256761
Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131
Oellers P, Karp CL, Shah RR, Winnick M, Matthews J, Dubovy S
Br J Ophthalmol 2014 Feb;98(2):275-6, 285. Epub 2013 Nov 28 doi: 10.1136/bjophthalmol-2013-303999. PMID: 24288390

Therapy

Machado RA, Oliveira LQ, Martelli-Júnior H, Pires FR, Carvas JB, Rogerio VE, Rabelo VD, Coletta RD
Med Oral Patol Oral Cir Bucal 2023 May 1;28(3):e278-e284. doi: 10.4317/medoral.25713. PMID: 36565218Free PMC Article
Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, Chiarion-Sileni V, Drucis K, Krajsova I, Hauschild A, Lorigan P, Wolter P, Long GV, Flaherty K, Nathan P, Ribas A, Martin AM, Sun P, Crist W, Legos J, Rubin SD, Little SM, Schadendorf D
N Engl J Med 2015 Jan 1;372(1):30-9. Epub 2014 Nov 16 doi: 10.1056/NEJMoa1412690. PMID: 25399551
Garbe C, Abusaif S, Eigentler TK
Recent Results Cancer Res 2014;201:215-25. doi: 10.1007/978-3-642-54490-3_13. PMID: 24756795
Ascierto PA, Kirkwood JM, Grob JJ, Simeone E, Grimaldi AM, Maio M, Palmieri G, Testori A, Marincola FM, Mozzillo N
J Transl Med 2012 Jul 9;10:85. doi: 10.1186/1479-5876-10-85. PMID: 22554099Free PMC Article
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA; BRIM-3 Study Group
N Engl J Med 2011 Jun 30;364(26):2507-16. Epub 2011 Jun 5 doi: 10.1056/NEJMoa1103782. PMID: 21639808Free PMC Article

Prognosis

Tisack A, Fotouhi A, Fidai C, Friedman BJ, Ozog D, Veenstra J
Br J Dermatol 2021 Sep;185(3):487-498. Epub 2021 Jun 14 doi: 10.1111/bjd.20389. PMID: 33864244
Takai T
J Dermatol 2017 Mar;44(3):304-314. doi: 10.1111/1346-8138.13696. PMID: 28256761
Anzalone CL, Cohen PR
Int J Dermatol 2014 Feb;53(2):131-6. Epub 2013 Dec 10 doi: 10.1111/ijd.12318. PMID: 24321108
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766
Stoll DM, Ackerman AB
Am J Dermatopathol 1980 Fall;2(3):265-71. doi: 10.1097/00000372-198000230-00017. PMID: 7258561

Clinical prediction guides

Murthy AB, Palaniappan V, Karthikeyan K, Anbarasan V
Int J Dermatol 2023 Oct;62(10):1218-1227. Epub 2023 Aug 27 doi: 10.1111/ijd.16817. PMID: 37634201
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Paprottka FJ, Krezdorn N, Narwan M, Turk M, Sorg H, Noah EM, Hebebrand D
Aesthetic Plast Surg 2018 Feb;42(1):310-321. Epub 2017 Nov 9 doi: 10.1007/s00266-017-1002-0. PMID: 29124377
Anzalone CL, Cohen PR
Int J Dermatol 2014 Feb;53(2):131-6. Epub 2013 Dec 10 doi: 10.1111/ijd.12318. PMID: 24321108
Griffiths RW
Br J Plast Surg 2004 Sep;57(6):485-501. doi: 10.1016/j.bjps.2004.05.007. PMID: 15308394

Recent systematic reviews

Machado RA, Oliveira LQ, Martelli-Júnior H, Pires FR, Carvas JB, Rogerio VE, Rabelo VD, Coletta RD
Med Oral Patol Oral Cir Bucal 2023 May 1;28(3):e278-e284. doi: 10.4317/medoral.25713. PMID: 36565218Free PMC Article
Neagu N, Dianzani C, Venuti A, Bonin S, Voidăzan S, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2023 Jan;37(1):40-46. Epub 2022 Sep 1 doi: 10.1111/jdv.18548. PMID: 36000380
Kampa F, Mitteldorf C
J Cutan Pathol 2021 Apr;48(4):495-510. Epub 2020 Nov 6 doi: 10.1111/cup.13894. PMID: 33047376
Chen P, Chen F, Zhou B
Clin Exp Dermatol 2019 Apr;44(3):243-251. Epub 2018 Oct 2 doi: 10.1111/ced.13751. PMID: 30280426
Savage JA, Maize JC Sr
Am J Dermatopathol 2014 May;36(5):422-9. doi: 10.1097/DAD.0000000000000031. PMID: 24366198

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