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Spindle cell nevus

MedGen UID:
60220
•Concept ID:
C0206738
•
Neoplastic Process
Synonyms: Nevi, Spindle Cell; Nevus, Spindle Cell; Spindle Cell Nevi; Spindle Cell Nevus
SNOMED CT: Spindle cell nevus (810003); Spindle cell nevus (253038006); Reed nevus (810003)
 
Monarch Initiative: MONDO:0044796

Definition

A nevus characterized by the presence of spindle-shaped melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell nevus

Professional guidelines

PubMed

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Differential diagnosis of melanocytic lesions and molecular biology.
Dummer R, Kerl K, Mihic D, Kamarachev J
Arch Dermatol 2011 Feb;147(2):232-3. doi: 10.1001/archdermatol.2010.438. PMID: 21339451

Recent clinical studies

Etiology

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Diagnosis

Modern Concepts in Melanocytic Tumors.
Fernandez-Flores A
Actas Dermosifiliogr 2023 May;114(5):402-412. Epub 2023 Jan 14 doi: 10.1016/j.ad.2023.01.001. PMID: 36649787
Spitz melanocytic tumours - a review.
Yeh I, Busam KJ
Histopathology 2022 Jan;80(1):122-134. doi: 10.1111/his.14583. PMID: 34958498
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Blue lesions.
Longo C, Scope A, Lallas A, Zalaudek I, Moscarella E, Gardini S, Argenziano G, Pellacani G
Dermatol Clin 2013 Oct;31(4):637-47, ix. Epub 2013 Aug 23 doi: 10.1016/j.det.2013.07.001. PMID: 24075551

Therapy

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
First-line axitinib therapy is less effective in metastatic renal cell carcinoma with spindle histology.
Numakura K, Kobayashi M, Muto Y, Sekine Y, Takahashi M, Kashima S, Yamamoto R, Koizumi A, Nara T, Saito M, Narita S, Nanjyo H, Habuchi T
Sci Rep 2020 Nov 18;10(1):20089. doi: 10.1038/s41598-020-77135-6. PMID: 33208816Free PMC Article
Molecular profiling of Spitz nevi identified by digital RNA counting.
Hillen LM, Geybels MS, Rennspiess D, Spassova I, Ritter C, Becker JC, Garmyn M, Zur Hausen A, Van den Oord J, Winnepenninckx V
Melanoma Res 2018 Dec;28(6):510-520. doi: 10.1097/CMR.0000000000000495. PMID: 30095598Free PMC Article
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.
Mandel VD, Persechino F, Berardi A, Ponti G, Ciardo S, Rossi C, Pellacani G, Farnetani F
Ital J Pediatr 2016 May 14;42(1):47. doi: 10.1186/s13052-016-0260-9. PMID: 27180150Free PMC Article
Safety and efficacy of sunitinib for advanced non-clear cell renal cell carcinoma.
Shi HZ, Tian J, Li CL
Asia Pac J Clin Oncol 2015 Dec;11(4):328-33. Epub 2015 Oct 15 doi: 10.1111/ajco.12408. PMID: 26471774

Prognosis

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Age and Melanocytic Lesions.
Shannon AB, Song Y, Xu X, Karakousis GC
Surg Oncol Clin N Am 2020 Jul;29(3):369-386. doi: 10.1016/j.soc.2020.02.005. PMID: 32482314
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Clinical prediction guides

Clinical, Morphological and Molecular Features of Spitz tumors.
Donati M, Mansour B, Hagstrom M, Gerami P, Kazakov DV
Cesk Patol 2024;60(1):35-48. PMID: 38697826
Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.
de la Fouchardiere A, Tirode F, Castillo C, Buisson A, Boivin F, Macagno N, Pissaloux D
Am J Surg Pathol 2022 Aug 1;46(8):1106-1115. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001888. PMID: 35319526
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Evolution of Spitz Nevi.
Emiroglu N, Yıldız P, Biyik Ozkaya D, Bahalı AG, Su O, Onsun N
Pediatr Dermatol 2017 Jul;34(4):438-445. Epub 2017 Jun 30 doi: 10.1111/pde.13184. PMID: 28664989
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article

Recent systematic reviews

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review.
Lallas A, Kyrgidis A, Ferrara G, Kittler H, Apalla Z, Castagnetti F, Longo C, Moscarella E, Piana S, Zalaudek I, Argenziano G
Lancet Oncol 2014 Apr;15(4):e178-83. doi: 10.1016/S1470-2045(13)70608-9. PMID: 24694641

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