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Leukopenia

MedGen UID:
6073
Concept ID:
C0023530
Disease or Syndrome
Synonyms: Leukocytopenia; Leukocytopenias; Leukopenias
SNOMED CT: Leukopenia (84828003); Leukocytopenia (84828003)
 
HPO: HP:0001882
Monarch Initiative: MONDO:0003785

Definition

An abnormal decreased number of leukocytes in the blood. [from HPO]

Conditions with this feature

Professional guidelines

PubMed

Grossi PA, Peghin M
Curr Opin Organ Transplant 2024 Apr 1;29(2):131-137. Epub 2024 Jan 30 doi: 10.1097/MOT.0000000000001139. PMID: 38288947Free PMC Article
Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE
J Clin Endocrinol Metab 2017 Sep 1;102(9):3111-3123. doi: 10.1210/jc.2017-01127. PMID: 28655174
Newman K, Owlia MB, El-Hemaidi I, Akhtari M
Autoimmun Rev 2013 May;12(7):784-91. Epub 2013 Feb 24 doi: 10.1016/j.autrev.2013.02.001. PMID: 23462431

Recent clinical studies

Etiology

Kleiboeker HL, Wang J, Borkowski N, Miner B, Prom A, Paplaczyk K, Wright J, Subramani MV, Arunachalam A, Betensley AD, Tomic R, Myers CN
Transpl Infect Dis 2024 Oct;26(5):e14337. Epub 2024 Jul 9 doi: 10.1111/tid.14337. PMID: 38980979
Kamitani F, Nishioka Y, Koizumi M, Nakajima H, Kurematsu Y, Okada S, Kubo S, Myojin T, Noda T, Imamura T, Takahashi Y
Sci Rep 2023 Nov 7;13(1):19336. doi: 10.1038/s41598-023-46307-5. PMID: 37935745Free PMC Article
Lam L, Mumford J, Keber B, Flanagan B
FP Essent 2019 Oct;485:11-16. PMID: 31613563
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
McCarthy MW, Kockler DR
Ann Pharmacother 2003 Feb;37(2):216-9. doi: 10.1177/106002800303700211. PMID: 12549951

Diagnosis

Kamitani F, Nishioka Y, Koizumi M, Nakajima H, Kurematsu Y, Okada S, Kubo S, Myojin T, Noda T, Imamura T, Takahashi Y
Sci Rep 2023 Nov 7;13(1):19336. doi: 10.1038/s41598-023-46307-5. PMID: 37935745Free PMC Article
Lam L, Mumford J, Keber B, Flanagan B
FP Essent 2019 Oct;485:11-16. PMID: 31613563
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
Velo-García A, Castro SG, Isenberg DA
J Autoimmun 2016 Nov;74:139-160. Epub 2016 Jul 25 doi: 10.1016/j.jaut.2016.07.001. PMID: 27461045
Tefferi A, Hanson CA, Inwards DJ
Mayo Clin Proc 2005 Jul;80(7):923-36. doi: 10.4065/80.7.923. PMID: 16007898Free PMC Article

Therapy

Wang C, Wang J, Qi Y
J Ethnopharmacol 2024 Jun 12;327:118044. Epub 2024 Mar 12 doi: 10.1016/j.jep.2024.118044. PMID: 38484953
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Burness CB, Duggan ST
Drugs 2016 Sep;76(14):1393-402. doi: 10.1007/s40265-016-0633-9. PMID: 27568360
Stern A, Green H, Paul M, Vidal L, Leibovici L
Cochrane Database Syst Rev 2014 Oct 1;2014(10):CD005590. doi: 10.1002/14651858.CD005590.pub3. PMID: 25269391Free PMC Article

Prognosis

Zhang Y, Zhang H, Xu H, Wang Y, Feng L, Yi F
World J Surg Oncol 2024 May 6;22(1):122. doi: 10.1186/s12957-024-03396-4. PMID: 38711095Free PMC Article
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868
Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE
J Clin Endocrinol Metab 2017 Sep 1;102(9):3111-3123. doi: 10.1210/jc.2017-01127. PMID: 28655174
Ntelios D, Mandros C, Potolidis E, Fanourgiakis P
BMJ Case Rep 2013 Oct 30;2013 doi: 10.1136/bcr-2013-201229. PMID: 24172776Free PMC Article
Sarin YK, Singh S, Singh T
Indian Pediatr 1998 Feb;35(2):129-37. PMID: 9707855

Clinical prediction guides

Doumeth SA, Kort J, Pamuk ON
Autoimmun Rev 2024 Nov;23(11):103652. Epub 2024 Sep 30 doi: 10.1016/j.autrev.2024.103652. PMID: 39357586
Kim E, Sher A, Abboud G, Schwartz M, Facciuto M, Tabrizian P, Knešaurek K, Fischman A, Patel R, Nowakowski S, Llovet J, Taouli B, Lookstein R
Lancet Gastroenterol Hepatol 2022 Sep;7(9):843-850. Epub 2022 May 23 doi: 10.1016/S2468-1253(22)00091-7. PMID: 35617978
Singh A, Hungund B, Kumar L, Pattanshetti M
Pathology 2018 Aug;50(5):540-548. Epub 2018 Jul 4 doi: 10.1016/j.pathol.2018.03.008. PMID: 30032928
Velo-García A, Castro SG, Isenberg DA
J Autoimmun 2016 Nov;74:139-160. Epub 2016 Jul 25 doi: 10.1016/j.jaut.2016.07.001. PMID: 27461045
Parent-Massin D
Toxicol Lett 2004 Oct 10;153(1):75-81. doi: 10.1016/j.toxlet.2004.04.024. PMID: 15342083

Recent systematic reviews

Doumeth SA, Kort J, Pamuk ON
Autoimmun Rev 2024 Nov;23(11):103652. Epub 2024 Sep 30 doi: 10.1016/j.autrev.2024.103652. PMID: 39357586
Ahn L, Park SW, Choi DJ
Integr Cancer Ther 2024 Jan-Dec;23:15347354231226115. doi: 10.1177/15347354231226115. PMID: 38427798Free PMC Article
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Stern A, Green H, Paul M, Vidal L, Leibovici L
Cochrane Database Syst Rev 2014 Oct 1;2014(10):CD005590. doi: 10.1002/14651858.CD005590.pub3. PMID: 25269391Free PMC Article

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