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Solitary Circumscribed Neuroma

MedGen UID:
608768
•Concept ID:
C0431126
•
Neoplastic Process
Synonyms: Palisaded Encapsulated Neuroma; Palisaded encapsulated neuroma; Solitary circumscribed neuroma
SNOMED CT: Palisaded encapsulated neuroma (404019003); Solitary circumscribed neuroma (404019003); Solitary circumscribed neuroma (253091003)

Definition

A benign peripheral nerve sheath tumor characterized by the presence of Schwann cells, axons, and perineurial fibroblasts. It usually arises from the skin of the head and neck or the oral mucosa. It presents as a solitary and painless nodular mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolitary Circumscribed Neuroma

Professional guidelines

PubMed

Diagnosis and management of schwannomas originating from the cervical vagus nerve.
Behuria S, Rout TK, Pattanayak S
Ann R Coll Surg Engl 2015 Mar;97(2):92-7. doi: 10.1308/003588414X14055925058355. PMID: 25723683Free PMC Article

Recent clinical studies

Etiology

Mesenchymal neoplasms of the tongue: A clinicopathologic study of 93 cases.
Ortiz Requena D, Velez-Torres JM, Diaz-Perez JA, Gomez-Fernandez C, Montgomery EA, Rosenberg AE
Hum Pathol 2024 Aug;150:42-50. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.005. PMID: 38876200

Diagnosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Solitary circumscribed neuroma of the conjunctiva: Differential diagnosis from neurofibroma is a must?
Kiyat P, Selver OB, Akalin T, Palamar M
Arq Bras Oftalmol 2020 Sep-Oct;83(5):427-429. doi: 10.5935/0004-2749.20200084. PMID: 32785439
Palisaded Encapsulated (Solitary Circumscribed) Neuroma: A Review of 30 Cases.
Leblebici C, Savli TC, Yeni B, Cin M, Aksu AEK
Int J Surg Pathol 2019 Aug;27(5):506-514. Epub 2019 Mar 5 doi: 10.1177/1066896919833172. PMID: 30834800
Solitary Circumscribed Neuroma: Dermoscopic clues to facilitate diagnosis.
Fernández-Crehuet P, Ruiz-Villaverde R
Sultan Qaboos Univ Med J 2018 Feb;18(1):e116-e117. Epub 2018 Apr 4 doi: 10.18295/squmj.2018.18.01.023. PMID: 29666696Free PMC Article
Solitary circumscribed neuroma of the skin (so-called palisaded, encapsulated neuroma). A clinicopathologic and immunohistochemical study.
Fletcher CD
Am J Surg Pathol 1989 Jul;13(7):574-80. doi: 10.1097/00000478-198907000-00005. PMID: 2660609

Prognosis

Solitary circumscribed neuroma of the glans penis. An unusual finding.
Valtueña J, Sánchez DR, Martínez-García G, Garayar-Cantero M, Barrutia-Etxebarría L, Hadi A, Hadi S, Manchado-López P, Garabito-Solovera EL
Dermatol Online J 2020 Dec 15;26(12) PMID: 33423423
Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600

Clinical prediction guides

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600
Solitary circumscribed neuroma of the palpebral conjunctiva: A rare location.
Ishida Y, Takahashi Y, Takahashi E, Kakizaki H
Cont Lens Anterior Eye 2016 Dec;39(6):471-473. Epub 2016 Aug 11 doi: 10.1016/j.clae.2016.08.002. PMID: 27522960
Nonscarring alopecia associated with solitary circumscribed neuroma.
Hernández-Cano N, Pizarro A, Lázaro TE, Mayor M, Burón I, Contreras F, Casado M
Dermatology 1997;195(3):265-7. doi: 10.1159/000245957. PMID: 9407176
An unusual solitary circumscribed neuroma (palisaded encapsulated neuroma) of the skin--with observations on the nature of pseudo-epitheliomatous hyperplasia.
Alexander J, Theaker JM
Histopathology 1991 Feb;18(2):175-7. doi: 10.1111/j.1365-2559.1991.tb01463.x. PMID: 2010183

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