U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alcoholic liver cirrhosis

MedGen UID:
6125
•Concept ID:
C0023891
•
Disease or Syndrome
Synonyms: Alcoholic Cirrhosis; Alcoholic Hepatic Cirrhosis; Alcoholic Liver Cirrhosis; Hepatic Cirrhosis, Alcoholic; Liver Cirrhosis, Alcoholic
SNOMED CT: Alcoholic cirrhosis (420054005); Alcoholic liver cirrhosis (420054005); Alcoholic cirrhosis of liver (420054005)
 
Monarch Initiative: MONDO:0006644

Definition

A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcoholic liver cirrhosis

Professional guidelines

PubMed

Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study.
Kim HI, Park SY, Shin HP
Sci Rep 2021 Mar 23;11(1):6648. doi: 10.1038/s41598-021-86197-z. PMID: 33758281Free PMC Article
Refractory CIDP: Clinical characteristics, antibodies and response to alternative treatment.
Godil J, Barrett MJ, Ensrud E, Chahin N, Karam C
J Neurol Sci 2020 Nov 15;418:117098. Epub 2020 Aug 15 doi: 10.1016/j.jns.2020.117098. PMID: 32841917
Management strategies in alcoholic liver disease.
Tilg H, Day CP
Nat Clin Pract Gastroenterol Hepatol 2007 Jan;4(1):24-34. doi: 10.1038/ncpgasthep0683. PMID: 17203086

Recent clinical studies

Etiology

Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Cardiac manifestations in alcoholic liver disease.
Milić S, Lulić D, Štimac D, Ružić A, Zaputović L
Postgrad Med J 2016 Apr;92(1086):235-9. Epub 2016 Feb 5 doi: 10.1136/postgradmedj-2015-133755. PMID: 26850503
Fibrogenesis in alcoholic liver disease.
Fujii H, Kawada N
World J Gastroenterol 2014 Jul 7;20(25):8048-54. doi: 10.3748/wjg.v20.i25.8048. PMID: 25009376Free PMC Article
Alcoholism & depression.
Hall M
Home Healthc Nurse 2012 Oct;30(9):543-50; quiz 550-2. doi: 10.1097/NHH.0b013e31826a6719. PMID: 23026991
Alcohol and liver fibrosis.
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Diagnosis

Alcohol-Associated Cirrhosis.
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Non-invasive diagnosis of alcoholic liver disease.
Mueller S, Seitz HK, Rausch V
World J Gastroenterol 2014 Oct 28;20(40):14626-41. doi: 10.3748/wjg.v20.i40.14626. PMID: 25356026Free PMC Article
Alcohol and liver fibrosis.
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920
Alcoholic cirrhosis.
Burnett DA, Sorrell MF
Clin Gastroenterol 1981 May;10(2):443-55. PMID: 7018752

Therapy

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.
China L, Freemantle N, Forrest E, Kallis Y, Ryder SD, Wright G, Portal AJ, Becares Salles N, Gilroy DW, O'Brien A; ATTIRE Trial Investigators
N Engl J Med 2021 Mar 4;384(9):808-817. doi: 10.1056/NEJMoa2022166. PMID: 33657293
Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
New approaches for fibrosis regression in alcoholic cirrhosis.
Mehal W, To U
Hepatol Int 2016 Sep;10(5):773-8. Epub 2016 Jul 26 doi: 10.1007/s12072-016-9752-3. PMID: 27460408Free PMC Article
Alcohol and liver fibrosis.
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Prognosis

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.
Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Spur-cell anemia.
Maharaj S, Murray D, Chang S, Cisak K
Cleve Clin J Med 2020 Nov 2;87(11):649-650. doi: 10.3949/ccjm.87a.20044. PMID: 33139258
Alcohol-Associated Cirrhosis.
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Lethal phlegmonous colitis.
Gilbert JD, Byard RW
Med Sci Law 2018 Jul;58(3):186-188. Epub 2018 May 21 doi: 10.1177/0025802418778165. PMID: 29783922
The prognosis and outcome of alcoholic liver disease.
Morgan MY
Alcohol Alcohol Suppl 1994;2:335-43. PMID: 8974353

Clinical prediction guides

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.
Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D; GenomALC Consortium
J Hepatol 2022 Feb;76(2):275-282. Epub 2021 Oct 14 doi: 10.1016/j.jhep.2021.10.005. PMID: 34656649Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
The Pathology of Alcoholic Liver Disease.
Alpert L, Hart J
Clin Liver Dis 2016 Aug;20(3):473-89. Epub 2016 Apr 9 doi: 10.1016/j.cld.2016.02.006. PMID: 27373610
Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease.
Lombardi R, Buzzetti E, Roccarina D, Tsochatzis EA
World J Gastroenterol 2015 Oct 21;21(39):11044-52. doi: 10.3748/wjg.v21.i39.11044. PMID: 26494961Free PMC Article
Liver fibrosis markers in alcoholic liver disease.
Chrostek L, Panasiuk A
World J Gastroenterol 2014 Jul 7;20(25):8018-23. doi: 10.3748/wjg.v20.i25.8018. PMID: 25009372Free PMC Article

Recent systematic reviews

Medications for alcohol use disorder promote abstinence in alcohol-associated cirrhosis: Results from a systematic review and meta-analysis.
Gratacós-Ginès J, Bruguera P, Pérez-Guasch M, López-Lazcano A, Borràs R, Hernández-Évole H, Pons-Cabrera MT, Lligoña A, Bataller R, Ginès P, López-Pelayo H, Pose E
Hepatology 2024 Feb 1;79(2):368-379. Epub 2023 Aug 25 doi: 10.1097/HEP.0000000000000570. PMID: 37625154
Hepatocellular Carcinoma Incidence in Alcohol-Associated Cirrhosis: Systematic Review and Meta-analysis.
Huang DQ, Tan DJH, Ng CH, Amangurbanova M, Sutter N, Lin Tay PW, Lim WH, Yong JN, Tang A, Syn N, Muthiah MD, Tan EXX, Dave S, Tay B, Majzoub AM, Gerberi D, Kim BK, Loomba R
Clin Gastroenterol Hepatol 2023 May;21(5):1169-1177. Epub 2022 Aug 5 doi: 10.1016/j.cgh.2022.06.032. PMID: 35940513Free PMC Article
Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease.
Pavlov CS, Casazza G, Semenistaia M, Nikolova D, Tsochatzis E, Liusina E, Ivashkin VT, Gluud C
Cochrane Database Syst Rev 2016 Mar 2;3(3):CD011602. doi: 10.1002/14651858.CD011602.pub2. PMID: 26934429Free PMC Article
Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis.
Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J
Aliment Pharmacol Ther 2016 Mar;43(5):562-74. Epub 2016 Jan 25 doi: 10.1111/apt.13523. PMID: 26806124
Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis.
Rambaldi A, Gluud C
Cochrane Database Syst Rev 2005 Apr 18;2005(2):CD002148. doi: 10.1002/14651858.CD002148.pub2. PMID: 15846629Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...