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Abnormal blood urea nitrogen concentration

MedGen UID:
614150
•Concept ID:
C0438242
•
Finding
Synonyms: Abnormal BUN concentration; Blood urea abnormal; Blood urea outside reference range
SNOMED CT: Blood urea abnormal (166712009); Blood urea outside reference range (166712009)
 
HPO: HP:0031970

Definition

Any deviation from the normal concentration of urea nitrogen in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal blood urea nitrogen concentration

Professional guidelines

PubMed

Multifunctional nanobubbles carrying indocyanine green and paclitaxel for molecular imaging and the treatment of prostate cancer.
Lan M, Zhu L, Wang Y, Shen D, Fang K, Liu Y, Peng Y, Qiao B, Guo Y
J Nanobiotechnology 2020 Sep 3;18(1):121. doi: 10.1186/s12951-020-00650-1. PMID: 32883330Free PMC Article
An 18-yr prospective study of pediatric diabetic ketoacidosis: an approach to minimizing the risk of brain herniation during treatment.
Fiordalisi I, Novotny WE, Holbert D, Finberg L, Harris GD; Critical Care Management Group
Pediatr Diabetes 2007 Jun;8(3):142-9. doi: 10.1111/j.1399-5448.2007.00253.x. PMID: 17550424
Efficacy and safety of captopril in the treatment of severe childhood hypertension: report of the International Collaborative Study Group.
Mirkin BL, Newman TJ
Pediatrics 1985 Jun;75(6):1091-100. PMID: 3889818

Recent clinical studies

Etiology

Rhabdomyolysis, Methamphetamine, Amphetamine and MDMA Use: Associated Factors and Risks.
Richards JR, Wang CG, Fontenette RW, Stuart RP, McMahon KF, Turnipseed SD
J Dual Diagn 2020 Oct;16(4):429-437. Epub 2020 Jul 9 doi: 10.1080/15504263.2020.1786617. PMID: 32644906
Tolvaptan promotes urinary excretion of sodium and urea: a retrospective cohort study.
Minami S, Hamano T, Iwatani H, Mizui M, Kimura Y, Isaka Y
Clin Exp Nephrol 2018 Jun;22(3):550-561. Epub 2017 Oct 20 doi: 10.1007/s10157-017-1475-9. PMID: 29052786
Hyponatremia, hyposmolality, and hypotonicity: tables and fables.
Oster JR, Singer I
Arch Intern Med 1999 Feb 22;159(4):333-6. doi: 10.1001/archinte.159.4.333. PMID: 10030305
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Arsine poisoning.
Hocken AG, Bradshaw G
Br J Ind Med 1970 Jan;27(1):56-60. doi: 10.1136/oem.27.1.56. PMID: 5418920Free PMC Article

Diagnosis

Rhabdomyolysis, Methamphetamine, Amphetamine and MDMA Use: Associated Factors and Risks.
Richards JR, Wang CG, Fontenette RW, Stuart RP, McMahon KF, Turnipseed SD
J Dual Diagn 2020 Oct;16(4):429-437. Epub 2020 Jul 9 doi: 10.1080/15504263.2020.1786617. PMID: 32644906
Serum calcium concentration affects signal changes on diffusion-weighted imaging in hypoglycemic encephalopathy.
Koh E, Tsai LK, Hong CT
AJNR Am J Neuroradiol 2012 Feb;33(2):297-300. Epub 2011 Oct 27 doi: 10.3174/ajnr.A2766. PMID: 22033722Free PMC Article
Hyponatremia, hyposmolality, and hypotonicity: tables and fables.
Oster JR, Singer I
Arch Intern Med 1999 Feb 22;159(4):333-6. doi: 10.1001/archinte.159.4.333. PMID: 10030305
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Ifosfamide-induced Fanconi syndrome.
Garcia AA
Ann Pharmacother 1995 Jun;29(6):590-1. doi: 10.1177/106002809502900607. PMID: 7663031

Therapy

Rhabdomyolysis, Methamphetamine, Amphetamine and MDMA Use: Associated Factors and Risks.
Richards JR, Wang CG, Fontenette RW, Stuart RP, McMahon KF, Turnipseed SD
J Dual Diagn 2020 Oct;16(4):429-437. Epub 2020 Jul 9 doi: 10.1080/15504263.2020.1786617. PMID: 32644906
Effect of ketamine combined with lidocaine in pediatric anesthesia.
Fang H, Li HF, Yang M, Zhang FX, Liao R, Wang RR, Wang QY, Zheng PC, Zhang JP
J Clin Lab Anal 2020 Apr;34(4):e23115. Epub 2019 Nov 15 doi: 10.1002/jcla.23115. PMID: 31733006Free PMC Article
Tolvaptan promotes urinary excretion of sodium and urea: a retrospective cohort study.
Minami S, Hamano T, Iwatani H, Mizui M, Kimura Y, Isaka Y
Clin Exp Nephrol 2018 Jun;22(3):550-561. Epub 2017 Oct 20 doi: 10.1007/s10157-017-1475-9. PMID: 29052786
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Publow SW, Branam DL
Am J Health Syst Pharm 2010 Oct 1;67(19):1606-10. doi: 10.2146/ajhp090657. PMID: 20852161
Ifosfamide-induced Fanconi syndrome.
Garcia AA
Ann Pharmacother 1995 Jun;29(6):590-1. doi: 10.1177/106002809502900607. PMID: 7663031

Prognosis

Electrolyte Changes in Contemporary Hemodialysis: A Secondary Analysis of the Monitoring in Dialysis (MiD) Study.
Correa S, Scovner KM, Tumlin JA, Roy-Chaudhury P, Koplan BA, Costea AI, Kher V, Williamson D, Pokhariyal S, McClure CK, Mc Causland FR, Charytan DM; MiD Investigators and Committees; MiD Investigators and Committees
Kidney360 2021 Apr;2(4):695-707. Epub 2021 Apr 29 doi: 10.34067/KID.0007452020. PMID: 34676372Free PMC Article
Follow-up study on COVID-19 survivors one year after discharge from hospital.
Zhao Y, Yang C, An X, Xiong Y, Shang Y, He J, Qiu Y, Zhang N, Huang L, Jia J, Xu Q, Zhang L, Zhao J, Pei G, Luo H, Wang J, Li Q, Gao Y, Xu A
Int J Infect Dis 2021 Nov;112:173-182. Epub 2021 Sep 12 doi: 10.1016/j.ijid.2021.09.017. PMID: 34520845Free PMC Article
Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates.
Kirtane AJ, Leder DM, Waikar SS, Chertow GM, Ray KK, Pinto DS, Karmpaliotis D, Burger AJ, Murphy SA, Cannon CP, Braunwald E, Gibson CM; TIMI Study Group
J Am Coll Cardiol 2005 Jun 7;45(11):1781-6. doi: 10.1016/j.jacc.2005.02.068. PMID: 15936606
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Arsine poisoning.
Hocken AG, Bradshaw G
Br J Ind Med 1970 Jan;27(1):56-60. doi: 10.1136/oem.27.1.56. PMID: 5418920Free PMC Article

Clinical prediction guides

Effect of ketamine combined with lidocaine in pediatric anesthesia.
Fang H, Li HF, Yang M, Zhang FX, Liao R, Wang RR, Wang QY, Zheng PC, Zhang JP
J Clin Lab Anal 2020 Apr;34(4):e23115. Epub 2019 Nov 15 doi: 10.1002/jcla.23115. PMID: 31733006Free PMC Article
Clinical Assessment of Intravenous Endothelial Progenitor Cell Transplantation in Dogs.
Lee SH, Ra JC, Oh HJ, Kim MJ, Setyawan EMN, Choi YB, Yang JW, Kang SK, Han SH, Kim GA, Lee BC
Cell Transplant 2019 Jul;28(7):943-954. Epub 2019 Apr 24 doi: 10.1177/0963689718821686. PMID: 31018670Free PMC Article
Tolvaptan promotes urinary excretion of sodium and urea: a retrospective cohort study.
Minami S, Hamano T, Iwatani H, Mizui M, Kimura Y, Isaka Y
Clin Exp Nephrol 2018 Jun;22(3):550-561. Epub 2017 Oct 20 doi: 10.1007/s10157-017-1475-9. PMID: 29052786
Clinical and echocardiographic characteristics of elderly hospitalized patients with high levels of NT-proBNP without clinical diagnosis of heart failure.
Lelli D, Pedone C, Rossi FF, Incalzi RA
Aging Clin Exp Res 2014 Dec;26(6):607-13. Epub 2014 Apr 30 doi: 10.1007/s40520-014-0226-y. PMID: 24781829
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086

Recent systematic reviews

Higher versus lower protein intake in formula-fed low birth weight infants.
Premji SS, Fenton TR, Sauve RS
Cochrane Database Syst Rev 2006 Jan 25;(1):CD003959. doi: 10.1002/14651858.CD003959.pub2. PMID: 16437468

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