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Abnormal blood urea nitrogen concentration

MedGen UID:
614150
•Concept ID:
C0438242
•
Finding
Synonyms: Abnormal BUN concentration; Blood urea abnormal; Blood urea outside reference range
SNOMED CT: Blood urea abnormal (166712009); Blood urea outside reference range (166712009)
 
HPO: HP:0031970

Definition

Any deviation from the normal concentration of urea nitrogen in the blood. [from HPO]

Professional guidelines

PubMed

Multifunctional nanobubbles carrying indocyanine green and paclitaxel for molecular imaging and the treatment of prostate cancer.
Lan M, Zhu L, Wang Y, Shen D, Fang K, Liu Y, Peng Y, Qiao B, Guo Y
J Nanobiotechnology 2020 Sep 3;18(1):121. doi: 10.1186/s12951-020-00650-1. PMID: 32883330Free PMC Article
An 18-yr prospective study of pediatric diabetic ketoacidosis: an approach to minimizing the risk of brain herniation during treatment.
Fiordalisi I, Novotny WE, Holbert D, Finberg L, Harris GD; Critical Care Management Group
Pediatr Diabetes 2007 Jun;8(3):142-9. doi: 10.1111/j.1399-5448.2007.00253.x. PMID: 17550424
Dietary treatment of chronic renal failure.
Berlyne GM, Gaan D, Ginks WR
Am J Clin Nutr 1968 Jun;21(6):547-52. doi: 10.1093/ajcn/21.6.547. PMID: 5666632

Recent clinical studies

Etiology

Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Nishikimi M, Rasul R, Sison CP, Jafari D, Shoaib M, Shinozaki K, Li T, Hayashida K, Rolston DM, Hirsch JS, Becker LB; Northwell Health COVID-19 Research Consortium
Sci Rep 2021 Oct 26;11(1):21124. doi: 10.1038/s41598-021-00591-1. PMID: 34702896Free PMC Article
Abnormal Osmolality Gap Exists in Distal Symmetric Polyneuropathy.
Akaishi T, Takahashi T, Nakashima I, Aoki M
Tohoku J Exp Med 2018 Sep;246(1):59-64. doi: 10.1620/tjem.246.59. PMID: 30270254
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Sickle-cell nephropathy: MR imaging.
Lande IM, Glazer GM, Sarnaik S, Aisen A, Rucknagel D, Martel W
Radiology 1986 Feb;158(2):379-83. doi: 10.1148/radiology.158.2.3941863. PMID: 3941863
Arsine poisoning.
Hocken AG, Bradshaw G
Br J Ind Med 1970 Jan;27(1):56-60. doi: 10.1136/oem.27.1.56. PMID: 5418920Free PMC Article

Diagnosis

Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Nishikimi M, Rasul R, Sison CP, Jafari D, Shoaib M, Shinozaki K, Li T, Hayashida K, Rolston DM, Hirsch JS, Becker LB; Northwell Health COVID-19 Research Consortium
Sci Rep 2021 Oct 26;11(1):21124. doi: 10.1038/s41598-021-00591-1. PMID: 34702896Free PMC Article
Abnormal Osmolality Gap Exists in Distal Symmetric Polyneuropathy.
Akaishi T, Takahashi T, Nakashima I, Aoki M
Tohoku J Exp Med 2018 Sep;246(1):59-64. doi: 10.1620/tjem.246.59. PMID: 30270254
Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis.
Glaser NS, Wootton-Gorges SL, Buonocore MH, Marcin JP, Rewers A, Strain J, DiCarlo J, Neely EK, Barnes P, Kuppermann N
Pediatr Diabetes 2006 Apr;7(2):75-80. doi: 10.1111/j.1399-543X.2006.00156.x. PMID: 16629712
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Sickle-cell nephropathy: MR imaging.
Lande IM, Glazer GM, Sarnaik S, Aisen A, Rucknagel D, Martel W
Radiology 1986 Feb;158(2):379-83. doi: 10.1148/radiology.158.2.3941863. PMID: 3941863

Therapy

Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.
Lawitz E, Sulkowski M, Jacobson I, Kraft WK, Maliakkal B, Al-Ibrahim M, Gordon SC, Kwo P, Rockstroh JK, Panorchan P, Miller M, Caro L, Barnard R, Hwang PM, Gress J, Quirk E, Mobashery N
Antiviral Res 2013 Sep;99(3):214-20. Epub 2013 Jun 7 doi: 10.1016/j.antiviral.2013.05.015. PMID: 23747481
Nesiritide therapy in a term neonate with renal disease.
Moffett BS, Jefferies JL, Rossano J, Towbin JA
Pharmacotherapy 2006 Feb;26(2):281-4. doi: 10.1592/phco.26.2.281. PMID: 16466334
Effect of dialysis on erythrocyte membrane of chronically hemodialyzed patients.
Ibrahim FF, Ghannam MM, Ali FM
Ren Fail 2002 Nov;24(6):779-90. doi: 10.1081/jdi-120015680. PMID: 12472200
Consequences of candidemia for pediatric patients.
Turner RB, Donowitz LG, Hendley JO
Am J Dis Child 1985 Feb;139(2):178-80. doi: 10.1001/archpedi.1985.02140040080032. PMID: 3976590
Effects of urea and cyanate on sickling in vitro.
Segel GB, Feig SA, Mentzer WC, McCaffrey RP, Wells R, Bunn HF, Shohet SB, Nathan DG
N Engl J Med 1972 Jul 13;287(2):59-64. doi: 10.1056/NEJM197207132870201. PMID: 5031386

Prognosis

Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Nishikimi M, Rasul R, Sison CP, Jafari D, Shoaib M, Shinozaki K, Li T, Hayashida K, Rolston DM, Hirsch JS, Becker LB; Northwell Health COVID-19 Research Consortium
Sci Rep 2021 Oct 26;11(1):21124. doi: 10.1038/s41598-021-00591-1. PMID: 34702896Free PMC Article
Nesiritide therapy in a term neonate with renal disease.
Moffett BS, Jefferies JL, Rossano J, Towbin JA
Pharmacotherapy 2006 Feb;26(2):281-4. doi: 10.1592/phco.26.2.281. PMID: 16466334
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Consequences of candidemia for pediatric patients.
Turner RB, Donowitz LG, Hendley JO
Am J Dis Child 1985 Feb;139(2):178-80. doi: 10.1001/archpedi.1985.02140040080032. PMID: 3976590
Arsine poisoning.
Hocken AG, Bradshaw G
Br J Ind Med 1970 Jan;27(1):56-60. doi: 10.1136/oem.27.1.56. PMID: 5418920Free PMC Article

Clinical prediction guides

Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Nishikimi M, Rasul R, Sison CP, Jafari D, Shoaib M, Shinozaki K, Li T, Hayashida K, Rolston DM, Hirsch JS, Becker LB; Northwell Health COVID-19 Research Consortium
Sci Rep 2021 Oct 26;11(1):21124. doi: 10.1038/s41598-021-00591-1. PMID: 34702896Free PMC Article
Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis.
Glaser NS, Wootton-Gorges SL, Buonocore MH, Marcin JP, Rewers A, Strain J, DiCarlo J, Neely EK, Barnes P, Kuppermann N
Pediatr Diabetes 2006 Apr;7(2):75-80. doi: 10.1111/j.1399-543X.2006.00156.x. PMID: 16629712
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086
Consequences of candidemia for pediatric patients.
Turner RB, Donowitz LG, Hendley JO
Am J Dis Child 1985 Feb;139(2):178-80. doi: 10.1001/archpedi.1985.02140040080032. PMID: 3976590
Renal disease in familial dysautonomia.
Pearson J, Gallo G, Gluck M, Axelrod F
Kidney Int 1980 Jan;17(1):102-12. doi: 10.1038/ki.1980.12. PMID: 7374014

Recent systematic reviews

Higher versus lower protein intake in formula-fed low birth weight infants.
Premji SS, Fenton TR, Sauve RS
Cochrane Database Syst Rev 2006 Jan 25;(1):CD003959. doi: 10.1002/14651858.CD003959.pub2. PMID: 16437468

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