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Flame-shaped retinal hemorrhage

MedGen UID:
633875
Concept ID:
C0474357
Disease or Syndrome
Synonyms: Feathered retinal heme; Flame-shaped hemorrhage; Flame-shaped retinal haemorrhage; Linear retina heme; Retinal flame hemorrhage; Retinal flame-shaped hemorrhage; Retinal nerve fiber layer hemorrhage
SNOMED CT: Retinal flame hemorrhage (247132001); Retinal nerve fiber layer hemorrhage (247132001); Flame-shaped hemorrhage (247132001); Retinal flame-shaped hemorrhage (247132001)
 
HPO: HP:0025241

Definition

A type of retinal hemorrhage that is located within the nerve fiber layer (NFL) of the retina and that exhibits a characteristic flame shape which results from constraints by the structure of the NFL (axons of the ganglion cells). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlame-shaped retinal hemorrhage

Recent clinical studies

Etiology

Haj Najeeb B, Deak GG, Schmidt-Erfurth U, Gerendas BS
Acta Ophthalmol 2022 Feb;100(1):e270-e277. Epub 2021 Apr 5 doi: 10.1111/aos.14866. PMID: 33821577Free PMC Article
Hemalatha BC, Kalpana BN, Shilpa YD, Ravi B, Bhavana G, Meghana S, Basumatary J
Indian J Ophthalmol 2021 Aug;69(8):2147-2150. doi: 10.4103/ijo.IJO_3616_20. PMID: 34304198Free PMC Article
Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N
Retina 2017 Mar;37(3):500-508. doi: 10.1097/IAE.0000000000001196. PMID: 27611056
Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N
Sci Rep 2016 Jun 23;6:28554. doi: 10.1038/srep28554. PMID: 27334338Free PMC Article
Christiansen SP, Muñoz M, Capó H
J Pediatr Ophthalmol Strabismus 1993 Jan-Feb;30(1):24-7. doi: 10.3928/0191-3913-19930101-07. PMID: 8455121

Diagnosis

Chen X, Wang M, Tang Y, Xie B, Nie X, Cai S
BMC Ophthalmol 2022 Nov 16;22(1):440. doi: 10.1186/s12886-022-02661-y. PMID: 36384467Free PMC Article
Pereira LA, Soares LCM, Nascimento PA, Cirillo LRN, Sakuma HT, Veiga GLD, Fonseca FLA, Lima VL, Abucham-Neto JZ
Br J Ophthalmol 2022 Jan;106(1):102-105. Epub 2020 Oct 16 doi: 10.1136/bjophthalmol-2020-317576. PMID: 33067361
Hemalatha BC, Kalpana BN, Shilpa YD, Ravi B, Bhavana G, Meghana S, Basumatary J
Indian J Ophthalmol 2021 Aug;69(8):2147-2150. doi: 10.4103/ijo.IJO_3616_20. PMID: 34304198Free PMC Article
Muraoka Y, Uji A, Tsujikawa A, Murakami T, Ooto S, Suzuma K, Takahashi A, Iida Y, Miwa Y, Hata M, Yoshimura N
Sci Rep 2016 Jun 23;6:28554. doi: 10.1038/srep28554. PMID: 27334338Free PMC Article
Togioka BM, Arnold MA, Bathurst MA, Ziegfeld SM, Nabaweesi R, Colombani PM, Chang DC, Abdullah F
J Emerg Med 2009 Jul;37(1):98-106. Epub 2008 Dec 11 doi: 10.1016/j.jemermed.2008.06.022. PMID: 19081701

Therapy

Haj Najeeb B, Deak GG, Schmidt-Erfurth U, Gerendas BS
Acta Ophthalmol 2022 Feb;100(1):e270-e277. Epub 2021 Apr 5 doi: 10.1111/aos.14866. PMID: 33821577Free PMC Article
Yang YY, He MS
BMC Ophthalmol 2019 Nov 14;19(1):228. doi: 10.1186/s12886-019-1243-6. PMID: 31726996Free PMC Article
Furtado JM, Toscano M, Castro V, Rodrigues MW
Ocul Immunol Inflamm 2016 Oct;24(5):568-70. Epub 2015 Oct 15 doi: 10.3109/09273948.2015.1047035. PMID: 26472315
Christiansen SP, Muñoz M, Capó H
J Pediatr Ophthalmol Strabismus 1993 Jan-Feb;30(1):24-7. doi: 10.3928/0191-3913-19930101-07. PMID: 8455121
Classé JG
J Am Optom Assoc 1980 Dec;51(12):1091-3. PMID: 7204820

Prognosis

Haj Najeeb B, Deak GG, Schmidt-Erfurth U, Gerendas BS
Acta Ophthalmol 2022 Feb;100(1):e270-e277. Epub 2021 Apr 5 doi: 10.1111/aos.14866. PMID: 33821577Free PMC Article
Lani-Louzada R, Ramos CDVF, Cordeiro RM, Sadun AA
PLoS One 2020;15(12):e0243346. Epub 2020 Dec 3 doi: 10.1371/journal.pone.0243346. PMID: 33270751Free PMC Article
Stingl JV, Nunez LP, Schuster AK, Hoffmann EM
BMC Ophthalmol 2020 Oct 27;20(1):428. doi: 10.1186/s12886-020-01662-z. PMID: 33109147Free PMC Article
Togioka BM, Arnold MA, Bathurst MA, Ziegfeld SM, Nabaweesi R, Colombani PM, Chang DC, Abdullah F
J Emerg Med 2009 Jul;37(1):98-106. Epub 2008 Dec 11 doi: 10.1016/j.jemermed.2008.06.022. PMID: 19081701
Christiansen SP, Muñoz M, Capó H
J Pediatr Ophthalmol Strabismus 1993 Jan-Feb;30(1):24-7. doi: 10.3928/0191-3913-19930101-07. PMID: 8455121

Clinical prediction guides

Casarini B, Bruni F, Rubino P, Mora P
Eur J Ophthalmol 2023 Jul;33(4):NP62-NP65. Epub 2022 May 3 doi: 10.1177/11206721221098880. PMID: 35505605Free PMC Article
Güven YZ, Akbalık T, Akay F
Indian J Ophthalmol 2022 Jun;70(6):2195-2196. doi: 10.4103/ijo.IJO_680_22. PMID: 35648015Free PMC Article
Lani-Louzada R, Ramos CDVF, Cordeiro RM, Sadun AA
PLoS One 2020;15(12):e0243346. Epub 2020 Dec 3 doi: 10.1371/journal.pone.0243346. PMID: 33270751Free PMC Article
Daniel E, Ying GS, Siatkowski RM, Pan W, Smith E, Quinn GE; e-ROP Cooperative Group
Ophthalmology 2017 Mar;124(3):374-381. Epub 2016 Dec 13 doi: 10.1016/j.ophtha.2016.10.040. PMID: 27986386Free PMC Article
Ganesh A, Jenny C, Geyer J, Shouldice M, Levin AV
Ophthalmology 2004 Jul;111(7):1428-31. doi: 10.1016/j.ophtha.2003.10.028. PMID: 15234150

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