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Lymphatic vessel neoplasm

MedGen UID:: 64616
•Concept ID:: C0206619
•: Neoplastic Process

Synonyms:	Lymphatic Vessel Tumor; Lymphatic Vessel Tumors; Tumor, Lymphatic Vessel; Tumors, Lymphatic Vessel
SNOMED CT:	Lymphatic vessel tumor (115236002)

HPO:	HP:0012797
Monarch Initiative:	MONDO:0036870

Definition

A benign or malignant neoplasm arising from the lymphatic vessels. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLymphatic vessel neoplasm

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormality of the lymphatic system
    - Abnormal lymphatic vessel morphology
      - Lymphatic vessel neoplasm
        Benign Lymphatic Vessel Neoplasm
        Lymphangioma
        Acquired Progressive Lymphangioma
        Cavernous lymphangioma
        Conjunctival Lymphangioma
        Cystic hygroma
        Diffuse lymphatic malformation
        Gastric Lymphangioma
        Gorham-Stout disease
        Hemolymphangioma
        Intra-Abdominal Lymphangioma
        Kidney Lymphangioma
        Lymphangioma Circumscriptum
        Lymphangioma of the orbit
        Lymphedema-posterior choanal atresia syndrome
        Mediastinal cystic lymphangioma
        Mediastinal Lymphangioma
        Multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome
        Parotid Gland Lymphangioma
        Skin lymphangioma
        Thyroid Gland Lymphangioma
        Lymphangiomatosis
        Diffuse Pulmonary Lymphangiomatosis
        Liver Lymphangiomatosis
        Lymphangiomyoma
        Lymphangiomyomatosis
        Lung lymphangioleiomyomatosis
        Skin Lymphangioleiomyomatosis
        Lymphangiosarcoma
        Skin lymphangiosarcoma

Professional guidelines

PubMed

Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management.

McCarthy C, Gupta N, Johnson SR, Yu JJ, McCormack FX
Lancet Respir Med 2021 Nov;9(11):1313-1327. Epub 2021 Aug 27 doi: 10.1016/S2213-2600(21)00228-9. PMID: 34461049

Overview of primary adult retroperitoneal tumours.

Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897

A review of the management of lymphangiomas.

Ha J, Yu YC, Lannigan F
Curr Pediatr Rev 2014;10(3):238-48. doi: 10.2174/1573396309666131209210751. PMID: 25088344

See all (229)

Recent clinical studies

Etiology

Cystic lung disease.

Cabeza Martínez B, Giménez Palleiro A, Mazzini Florindez SP
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:265-276. doi: 10.1016/j.rxeng.2022.09.005. PMID: 36737165

Lymphatic and Mixed Malformations.

Hathaway BA, Radu S, Wilson J, Nauta AC
Lymphat Res Biol 2021 Feb;19(1):41-50. Epub 2021 Jan 25 doi: 10.1089/lrb.2020.0100. PMID: 33493408

Ultra-rare cystic disease.

Elia D, Torre O, Cassandro R, Caminati A, Harari S
Eur Respir Rev 2020 Sep 30;29(157) Epub 2020 Sep 2 doi: 10.1183/16000617.0163-2019. PMID: 32878971 Free PMC Article

Lymphatic manifestations of lymphangioleiomyomatosis.

Gupta R, Kitaichi M, Inoue Y, Kotloff R, McCormack FX
Lymphology 2014 Sep;47(3):106-17. PMID: 25420303

Lymphangiosarcoma.

Sordillo PP, Chapman R, Hajdu SI, Magill GB, Golbey RB
Cancer 1981 Oct 1;48(7):1674-9. doi: 10.1002/1097-0142(19811001)48:7<1674::aid-cncr2820480733>3.0.co;2-h. PMID: 7284967

See all (1759)

Diagnosis

Cystic hygroma of the neck: single center experience and literature review.

Damaskos C, Garmpis N, Manousi M, Garmpi A, Margonis GA, Spartalis E, Doula C, Michail-Strantzia C, Patelis N, Schizas D, Arkoumanis PT, Andreatos N, Tsourouflis G, Zavras N, Markatos K, Kontzoglou K, Antoniou EA
Eur Rev Med Pharmacol Sci 2017 Nov;21(21):4918-4923. PMID: 29164568

Splenic lymphangioma.

Ioannidis I, Kahn AG
Arch Pathol Lab Med 2015 Feb;139(2):278-82. doi: 10.5858/arpa.2013-0656-RS. PMID: 25611113

A review of the management of lymphangiomas.

Ha J, Yu YC, Lannigan F
Curr Pediatr Rev 2014;10(3):238-48. doi: 10.2174/1573396309666131209210751. PMID: 25088344

Lymphangioleiomyomatosis.

Ansótegui Barrera E, Mancheño Franch N, Vera-Sempere F, Padilla Alarcón J
Arch Bronconeumol 2011 Feb;47(2):85-93. Epub 2011 Jan 20 doi: 10.1016/j.arbres.2010.08.008. PMID: 21255897

Lymphangioleiomyomatosis.

Johnson SR
Eur Respir J 2006 May;27(5):1056-65. doi: 10.1183/09031936.06.00113303. PMID: 16707400

See all (3403)

Therapy

Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management.

McCarthy C, Gupta N, Johnson SR, Yu JJ, McCormack FX
Lancet Respir Med 2021 Nov;9(11):1313-1327. Epub 2021 Aug 27 doi: 10.1016/S2213-2600(21)00228-9. PMID: 34461049

Lymphangioleiomyomatosis.

Xu KF, Xu W, Liu S, Yu J, Tian X, Yang Y, Wang ST, Zhang W, Feng R, Zhang T
Semin Respir Crit Care Med 2020 Apr;41(2):256-268. Epub 2020 Apr 12 doi: 10.1055/s-0040-1702195. PMID: 32279296

Lymphangioleiomyomatosis.

Sclafani A, VanderLaan P
N Engl J Med 2018 Jun 7;378(23):2224. doi: 10.1056/NEJMicm1712581. PMID: 29874537

Emerging biomarkers of lymphangioleiomyomatosis.

Nijmeh J, El-Chemaly S, Henske EP
Expert Rev Respir Med 2018 Feb;12(2):95-102. Epub 2017 Dec 1 doi: 10.1080/17476348.2018.1409622. PMID: 29171770

A review of the management of lymphangiomas.

Ha J, Yu YC, Lannigan F
Curr Pediatr Rev 2014;10(3):238-48. doi: 10.2174/1573396309666131209210751. PMID: 25088344

See all (973)

Prognosis

Lymphangioleiomyomatosis.

Doubková M, Štefániková M, Čan V, Merta Z, Svoboda M
Klin Onkol 2019 Fall;32(5):367-374. doi: 10.14735/amko2019367. PMID: 31610670

Splenic lymphangioma.

Ioannidis I, Kahn AG
Arch Pathol Lab Med 2015 Feb;139(2):278-82. doi: 10.5858/arpa.2013-0656-RS. PMID: 25611113

Complex lymphatic anomalies.

Trenor CC 3rd, Chaudry G
Semin Pediatr Surg 2014 Aug;23(4):186-90. Epub 2014 Jul 22 doi: 10.1053/j.sempedsurg.2014.07.006. PMID: 25241096

Pancreatic hemolymphangioma.

Figueroa RM, Lopez GJ, Servin TE, Esquinca MH, Gómez-Pedraza A
JOP 2014 Jul 28;15(4):399-402. doi: 10.6092/1590-8577/2649. PMID: 25076353

Lymphangioleiomyomatosis.

Glassberg MK
Clin Chest Med 2004 Sep;25(3):573-82, vii. doi: 10.1016/j.ccm.2004.05.003. PMID: 15331193

See all (1941)

Clinical prediction guides

Lymphangioleiomyomatosis: pathogenesis, clinical features, diagnosis, and management.

McCarthy C, Gupta N, Johnson SR, Yu JJ, McCormack FX
Lancet Respir Med 2021 Nov;9(11):1313-1327. Epub 2021 Aug 27 doi: 10.1016/S2213-2600(21)00228-9. PMID: 34461049

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.

Guo M, Yu JJ, Perl AK, Wikenheiser-Brokamp KA, Riccetti M, Zhang EY, Sudha P, Adam M, Potter A, Kopras EJ, Giannikou K, Potter SS, Sherman S, Hammes SR, Kwiatkowski DJ, Whitsett JA, McCormack FX, Xu Y
Am J Respir Crit Care Med 2020 Nov 15;202(10):1373-1387. doi: 10.1164/rccm.201912-2445OC. PMID: 32603599 Free PMC Article

Lymphangioleiomyomatosis.

Doubková M, Štefániková M, Čan V, Merta Z, Svoboda M
Klin Onkol 2019 Fall;32(5):367-374. doi: 10.14735/amko2019367. PMID: 31610670

Complex lymphatic anomalies.

Trenor CC 3rd, Chaudry G
Semin Pediatr Surg 2014 Aug;23(4):186-90. Epub 2014 Jul 22 doi: 10.1053/j.sempedsurg.2014.07.006. PMID: 25241096

A review of the management of lymphangiomas.

Ha J, Yu YC, Lannigan F
Curr Pediatr Rev 2014;10(3):238-48. doi: 10.2174/1573396309666131209210751. PMID: 25088344

See all (1270)

Recent systematic reviews

Traumatic subdural hygroma and chronic subdural hematoma: A systematic review and meta-analysis.

Yu J, Tang J, Chen M, Ren Q, He J, Tang M, Zhang X, Liu Z, Ding H
J Clin Neurosci 2023 Jan;107:23-33. Epub 2022 Nov 30 doi: 10.1016/j.jocn.2022.11.010. PMID: 36462413

The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review.

Karinen S, Hujanen R, Salo T, Salem A
Cancer Sci 2022 Jan;113(1):17-27. Epub 2021 Nov 24 doi: 10.1111/cas.15199. PMID: 34775672 Free PMC Article

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis.

Zhang S, Zhang D, Yi S, Gong M, Lu C, Cai Y, Tang X, Zou L
Oncotarget 2017 Jan 10;8(2):2863-2873. doi: 10.18632/oncotarget.13752. PMID: 27926511 Free PMC Article

Genomic microarray in fetuses with increased nuchal translucency and normal karyotype: a systematic review and meta-analysis.

Grande M, Jansen FA, Blumenfeld YJ, Fisher A, Odibo AO, Haak MC, Borrell A
Ultrasound Obstet Gynecol 2015 Dec;46(6):650-8. doi: 10.1002/uog.14880. PMID: 25900824

The role of lymphatic and blood vessel invasion in predicting survival and methods of detection in patients with primary operable breast cancer.

Gujam FJ, Going JJ, Edwards J, Mohammed ZM, McMillan DC
Crit Rev Oncol Hematol 2014 Feb;89(2):231-41. Epub 2013 Sep 12 doi: 10.1016/j.critrevonc.2013.08.014. PMID: 24075309

See all (25)

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Lymphatic vessel neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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