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Mesoblastic nephroma

MedGen UID:
64620
Concept ID:
C0206628
Neoplastic Process
Synonyms: Mesoblastic Nephroma; Nephroma, Mesoblastic; Nephromas, Mesoblastic
SNOMED CT: Mesoblastic nephroma (11793003); Mesoblastic nephroma (307604008)
 
Monarch Initiative: MONDO:0003130

Definition

A solid, unencapsulated tumor of the kidney composed of spindle mesenchymal cells that resemble fibroblasts or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesoblastic nephroma

Professional guidelines

PubMed

Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Chen YX, Huang C, He QM, Wang Z, Huang L, Wang HY, Mei SS, Chai CW, Zhang GL, Zhong W, Li DZ
Prenat Diagn 2021 May;41(6):766-771. Epub 2021 Apr 5 doi: 10.1002/pd.5942. PMID: 33782977
Qureshi SS, Bhagat M, Verma K, Yadav S, Prasad M, Vora T, Chinnaswamy G, Amin N, Smriti V, Baheti A, Laskar S, Khanna N, Ramadwar M, Shah S
J Pediatr Urol 2020 Aug;16(4):475.e1-475.e9. Epub 2020 Jun 5 doi: 10.1016/j.jpurol.2020.05.168. PMID: 32620510

Recent clinical studies

Etiology

Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
Gooskens SL, Houwing ME, Vujanic GM, Dome JS, Diertens T, Coulomb-l'Herminé A, Godzinski J, Pritchard-Jones K, Graf N, van den Heuvel-Eibrink MM
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2017 Jan 26 doi: 10.1002/pbc.26437. PMID: 28124468
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153

Diagnosis

Sze SK
Clin Perinatol 2021 Mar;48(1):71-81. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.004. PMID: 33583508
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nat Commun 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. PMID: 32161258Free PMC Article
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Therapy

Tanné C, Pracros JP, Dijoud F, Mure PY, Bordet F, Duncan A, Bacchetta J
Arch Pediatr 2022 Feb;29(2):153-156. Epub 2022 Jan 14 doi: 10.1016/j.arcped.2021.11.013. PMID: 35039190
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Vokuhl C, Nourkami-Tutdibi N, Furtwängler R, Gessler M, Graf N, Leuschner I
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26925. PMID: 29286563
Walker RD
Semin Surg Oncol 1989;5(4):227-34. doi: 10.1002/ssu.2980050404. PMID: 2672229

Prognosis

Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Clinical prediction guides

Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Royer-Pokora B
Pediatr Nephrol 2013 Jan;28(1):13-23. Epub 2012 Mar 30 doi: 10.1007/s00467-012-2146-4. PMID: 22461142
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287

Recent systematic reviews

Cai S, Zhao W, Nie X, Abbas A, Fu L, Bihi S, Feng G, Liu T, Lv Y, Ma X, Peng X
J Pediatr Hematol Oncol 2017 Jul;39(5):355-361. doi: 10.1097/MPH.0000000000000715. PMID: 27906793

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