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Mesoblastic nephroma

MedGen UID:
64620
•Concept ID:
C0206628
•
Neoplastic Process
Synonyms: Mesoblastic Nephroma; Nephroma, Mesoblastic; Nephromas, Mesoblastic
SNOMED CT: Mesoblastic nephroma (11793003); Mesoblastic nephroma (307604008)
 
Monarch Initiative: MONDO:0003130

Definition

A solid, unencapsulated tumor of the kidney composed of spindle mesenchymal cells that resemble fibroblasts or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesoblastic nephroma

Professional guidelines

PubMed

Congenital mesoblastic nephroma: review of current management and outcomes in a single centre.
Rayner J, Vinycomb T, Wanaguru D, Jiwane A
ANZ J Surg 2023 Apr;93(4):1008-1011. Epub 2022 Nov 16 doi: 10.1111/ans.18165. PMID: 36382605
Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: Experience at a single center in China.
Chen YX, Huang C, He QM, Wang Z, Huang L, Wang HY, Mei SS, Chai CW, Zhang GL, Zhong W, Li DZ
Prenat Diagn 2021 May;41(6):766-771. Epub 2021 Apr 5 doi: 10.1002/pd.5942. PMID: 33782977
Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution.
Qureshi SS, Bhagat M, Verma K, Yadav S, Prasad M, Vora T, Chinnaswamy G, Amin N, Smriti V, Baheti A, Laskar S, Khanna N, Ramadwar M, Shah S
J Pediatr Urol 2020 Aug;16(4):475.e1-475.e9. Epub 2020 Jun 5 doi: 10.1016/j.jpurol.2020.05.168. PMID: 32620510

Recent clinical studies

Etiology

Report and follow-up on two new patients with congenital mesoblastic nephroma.
Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Imaging manifestations of congenital mesoblastic nephroma.
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Congenital mesoblastic nephroma: a single-centre series.
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
Congenital mesoblastic nephroma 50 years after its recognition: A narrative review.
Gooskens SL, Houwing ME, Vujanic GM, Dome JS, Diertens T, Coulomb-l'Herminé A, Godzinski J, Pritchard-Jones K, Graf N, van den Heuvel-Eibrink MM
Pediatr Blood Cancer 2017 Jul;64(7) Epub 2017 Jan 26 doi: 10.1002/pbc.26437. PMID: 28124468
Neonatal renal tumours.
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153

Diagnosis

Neonatal Renal Tumors.
Sze SK
Clin Perinatol 2021 Mar;48(1):71-81. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.004. PMID: 33583508
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nat Commun 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. PMID: 32161258Free PMC Article
Neonatal solid tumors.
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451
Neonatal renal tumours.
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153

Therapy

Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma.
Tanné C, Pracros JP, Dijoud F, Mure PY, Bordet F, Duncan A, Bacchetta J
Arch Pediatr 2022 Feb;29(2):153-156. Epub 2022 Jan 14 doi: 10.1016/j.arcped.2021.11.013. PMID: 35039190
Congenital mesoblastic nephroma: a single-centre series.
Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B
Ann R Coll Surg Engl 2020 Jan;102(1):67-70. Epub 2019 Sep 11 doi: 10.1308/rcsann.2019.0111. PMID: 31508997Free PMC Article
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.
Vokuhl C, Nourkami-Tutdibi N, Furtwängler R, Gessler M, Graf N, Leuschner I
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26925. PMID: 29286563
Mesoblastic nephroma: a report of the United Kingdom Children's Cancer and Leukaemia Group (CCLG).
England RJ, Haider N, Vujanic GM, Kelsey A, Stiller CA, Pritchard-Jones K, Powis M
Pediatr Blood Cancer 2011 May;56(5):744-8. Epub 2011 Jan 16 doi: 10.1002/pbc.22871. PMID: 21370406

Prognosis

Neonatal solid tumors.
Chandrasekaran A
Pediatr Neonatol 2018 Feb;59(1):65-70. Epub 2017 Jul 11 doi: 10.1016/j.pedneo.2016.12.007. PMID: 28736178
Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?
Jehangir S, Kurian JJ, Selvarajah D, Thomas RJ, Holland AJA
Pediatr Surg Int 2017 Nov;33(11):1183-1188. Epub 2017 Aug 30 doi: 10.1007/s00383-017-4149-5. PMID: 28856451
Upper urinary tract anomalies and perinatal renal tumors.
Shapiro E
Clin Perinatol 2014 Sep;41(3):679-94. Epub 2014 Jul 18 doi: 10.1016/j.clp.2014.05.014. PMID: 25155735
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287
Pediatric renal tumors.
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Clinical prediction guides

Report and follow-up on two new patients with congenital mesoblastic nephroma.
Serra G, Cimador M, Giuffrè M, Insinga V, Montante C, Pensabene M, Piro E, Salerno S, Schierz IAM, Corsello G
Ital J Pediatr 2023 Sep 19;49(1):124. doi: 10.1186/s13052-023-01523-7. PMID: 37726782Free PMC Article
Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging: A case report and literature review.
Che M, Yang F, Huang H, Zhang H, Han C, Sun N
Medicine (Baltimore) 2021 Jan 22;100(3):e24034. doi: 10.1097/MD.0000000000024034. PMID: 33546001Free PMC Article
Imaging manifestations of congenital mesoblastic nephroma.
Li Y, Liu X, Duan CF, Zhuang XH, Ge W, Song XF
Clin Imaging 2021 Apr;72:91-96. Epub 2020 Nov 4 doi: 10.1016/j.clinimag.2020.10.040. PMID: 33217676
Genetics of pediatric renal tumors.
Royer-Pokora B
Pediatr Nephrol 2013 Jan;28(1):13-23. Epub 2012 Mar 30 doi: 10.1007/s00467-012-2146-4. PMID: 22461142
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287

Recent systematic reviews

Multimorbidity and Genetic Characteristics of DICER1 Syndrome Based on Systematic Review.
Cai S, Zhao W, Nie X, Abbas A, Fu L, Bihi S, Feng G, Liu T, Lv Y, Ma X, Peng X
J Pediatr Hematol Oncol 2017 Jul;39(5):355-361. doi: 10.1097/MPH.0000000000000715. PMID: 27906793

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